cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.
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McLean JW, Tomlinson JE, Kuang WJ, Eaton DL, Chen EY, Fless GM, Scanu AM, Lawn RM
cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.
Nature. 1987 Nov 12-18;330(6144):132-7.
- PubMed ID
- 3670400 [ View in PubMed]
- Abstract
Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies.