Separation of signal transduction and adaptation functions of the aspartate receptor in bacterial sensing.
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Russo AF, Koshland DE Jr
Separation of signal transduction and adaptation functions of the aspartate receptor in bacterial sensing.
Science. 1983 Jun 3;220(4601):1016-20.
- PubMed ID
- 6302843 [ View in PubMed]
- Abstract
In order to investigate the functions of stimulus recognition, signal transduction, and adaptation, the aspartate receptor gene for bacterial chemotaxis in Salmonella typhimurium has been sequenced and modified. A carboxyl-terminal truncated receptor was shown to bind aspartate and to transmit a signal to change motility behavior. However, the truncated receptor showed greatly reduced methyl-accepting capacity, and did not allow adaptation to the sensory stimulation. The separation of receptor functions by alteration of primary structure emphasizes that the receptor is directly involved in adaptation and is not solely a device for transmitting a signal across a membrane.