An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase.
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Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW
An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase.
Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162.
- PubMed ID
- 10556888 [ View in PubMed]
- Abstract
Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.