Temperature-sensitive gels for intratumoral delivery of beta-lapachone: effect of cyclodextrins and ethanol.

Article Details

Citation
Copy to clipboard

Cunha-Filho MS, Alvarez-Lorenzo C, Martinez-Pacheco R, Landin M

Temperature-sensitive gels for intratumoral delivery of beta-lapachone: effect of cyclodextrins and ethanol.

ScientificWorldJournal. 2012;2012:126723. doi: 10.1100/2012/126723. Epub 2012 Apr 24.

PubMed ID
22629119 [ View in PubMed
]
Abstract

This work evaluated the potential of Pluronics (varieties F127 and P123) in combination with solubilizing agents to be used as syringeable in situ gelling depots of intratumoral beta-lapachone (betaLAP). Pluronic dispersions prepared at various concentrations in the absence and the presence of ethanol and randomly methylated beta-cyclodextrin (RMbetaCD) were characterized regarding their rheological properties, drug solubilization capacity, and in vitro release. Pluronic F127 (18-23%) formulations combined high ability to solubilize betaLAP (enhancement solubility factor up to 50), adequate gel temperature range (over 25 degrees C), and gel strength at 37 degrees C enough to guarantee the permanence of the formulation in the administration site for a period of time. betaLAP release rate was finely tuned by the concentration of the polymer and the addition of RMbetaCD (diffusion coefficient ranging between 9 and 69 mug . cm(-2)). The ethanol increases betaLAP release rate but simultaneously led to weak gels. This paper shows that betaLAP formulations involving temperature-reversible Pluronic gels may be suitable for intratumoral drug delivery purposes.

DrugBank Data that Cites this Article

Drugs