Determination of the activity of ponazuril against Sarcocystis neurona in cell cultures.

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Lindsay DS, Dubey JP, Kennedy TJ

Determination of the activity of ponazuril against Sarcocystis neurona in cell cultures.

Vet Parasitol. 2000 Sep 20;92(2):165-9.

PubMed ID
10946140 [ View in PubMed
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Abstract

The present study examined the efficacy of ponazuril in inhibiting merozoite production of Sarcocystis neurona in cell cultures. Ponazuril inhibited merozoite production by more that 90% in cultures of S. neurona treated with 1.0 microg/ml ponazuril and greater than 95% inhibition of merozoite production was observed when infected cultures were treated with 5.0 microg/ml ponazuril. Ponazuril may have promise as a therapeutic agent in the treatment of S. neurona induced equine protozoal myeloencephalitis (EPM) in horses.

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