Mode of action of ponazuril against Toxoplasma gondii tachyzoites in cell culture.

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Mitchell SM, Zajac AM, Davis WL, Lindsay DS

Mode of action of ponazuril against Toxoplasma gondii tachyzoites in cell culture.

J Eukaryot Microbiol. 2003;50 Suppl:689-90.

PubMed ID
14736221 [ View in PubMed
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Abstract

Toxoplasma gondii is an important apicomplexan parasite of humans and other warm-blooded animals. Ponazuril is a triazine anticoccidial recently approved for use in horses in the United States. We investigated the mode of action of ponazuril against developing RH strain T. gondii tachyzoites in African green monkey kidney cells. Host cells were infected with 2.0 x 10(5) tachyzoites and treated with 5 microg/ml ponazuril. Cultures were fixed and examined by transmission electron microscopy 3 days after treatment. Ponazuril interfered with normal parasite division. This led to the presence of multinucleate schizonts stages. Up to six tachyzoites were observed partially budded from the surface of these schizonts. Large vacuoles developed in these schizonts and they eventually degenerated.

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