NER, a new member of the gene family encoding the human steroid hormone nuclear receptor.
Article Details
- CitationCopy to clipboard
Shinar DM, Endo N, Rutledge SJ, Vogel R, Rodan GA, Schmidt A
NER, a new member of the gene family encoding the human steroid hormone nuclear receptor.
Gene. 1994 Sep 30;147(2):273-6.
- PubMed ID
- 7926814 [ View in PubMed]
- Abstract
NER, a new member of the steroid hormone nuclear receptor (NR)-encoding gene family, was isolated from a human osteosarcoma SAOS/B10 cell line cDNA library. NER codes for a polypeptide of 461 amino acids which contains the conserved sequences of the DNA-binding and ligand-binding domains of typical steroid hormone NR. It has highest homology with the retinoic acid receptors: 55% at the DNA-binding domain and 38-40% at the ligand-binding domain. A single transcript of 2.3 kb was detected in all cells and tissues tested. Although no ligand was identified for NER-I, its wide distribution may indicate that this novel steroid hormone NR may play a basic role in cell function.