Feedback inhibition of glycerol kinase, a catabolic enzyme in Escherichia coli.
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Zwaig N, Lin EC
Feedback inhibition of glycerol kinase, a catabolic enzyme in Escherichia coli.
Science. 1966 Aug 12;153(3737):755-7.
- PubMed ID
- 5328677 [ View in PubMed]
- Abstract
Fructose-1 ,6-diphosphate is a feedback inhibitor of the catabolic enzyme, glycerol kinase, in Escherichia coli. A mutant was isolated which produced a desensitized enzyme. Glucose was no longer as effective in preventing the utilization of exogenous glycerol by cells which synthesized constitutively such an altered enzyme, even though the usual degree of catabolite repression still operated.