Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides.

Article Details

Citation
Copy to clipboard

Andersen NM, Poehlsgaard J, Warrass R, Douthwaite S

Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides.

Antimicrob Agents Chemother. 2012 Nov;56(11):6033-6. doi: 10.1128/AAC.01250-12. Epub 2012 Aug 27.

PubMed ID
22926570 [ View in PubMed
]
Abstract

Tildipirosin is a 16-membered-ring macrolide developed to treat bacterial pathogens, including Mannheimia haemolytica and Pasteurella multocida, that cause respiratory tract infections in cattle and swine. Here we evaluated the efficacy of tildipirosin at inhibiting protein synthesis on the ribosome (50% inhibitory concentration [IC(50)], 0.23 +/- 0.01 muM) and compared it with the established veterinary macrolides tylosin, tilmicosin, and tulathromycin. Mutation and methylation at key rRNA nucleotides revealed differences in the interactions of these macrolides within their common ribosomal binding site.

DrugBank Data that Cites this Article

Drugs