Crystal structure of the signal sequence binding subunit of the signal recognition particle.
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Keenan RJ, Freymann DM, Walter P, Stroud RM
Crystal structure of the signal sequence binding subunit of the signal recognition particle.
Cell. 1998 Jul 24;94(2):181-91.
- PubMed ID
- 9695947 [ View in PubMed]
- Abstract
The crystal structure of the signal sequence binding subunit of the signal recognition particle (SRP) from Thermus aquaticus reveals a deep groove bounded by a flexible loop and lined with side chains of conserved hydrophobic residues. The groove defines a flexible, hydrophobic environment that is likely to contribute to the structural plasticity necessary for SRP to bind signal sequences of different lengths and amino acid sequence. The structure also reveals a helix-turn-helix motif containing an arginine-rich alpha helix that is required for binding to SRP RNA and is implicated in forming the core of an extended RNA binding surface.