ISG20, an actor of the innate immune response.
Article Details
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Degols G, Eldin P, Mechti N
ISG20, an actor of the innate immune response.
Biochimie. 2007 Jun-Jul;89(6-7):831-5. Epub 2007 Mar 15.
- PubMed ID
- 17445960 [ View in PubMed]
- Abstract
The interferon (IFN) system is a major effector of the innate immunity that allows time for the subsequent establishment of an adaptive immune response against wide-range pathogens. The effectiveness of IFN to control initial infection requires the cooperation between several pathways induced in the target cells. Recent studies that highlight the implication of the 3'-5' exonuclease ISG20 (IFN Stimulated Gene product of 20 kDa) in the host's defenses against pathogens are summarised in this review.