Rhomboid protease GlpG
Details
- Name
- Rhomboid protease GlpG
- Synonyms
- 3.4.21.105
- Intramembrane serine protease
- Gene Name
- glpG
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0007473|Rhomboid protease GlpG MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPA DPRYLAASWQAGHTGSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVM LWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLI SALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAG WFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK
- Number of residues
- 276
- Molecular Weight
- 31306.455
- Theoretical pI
- 9.48
- GO Classification
- Functionsendopeptidase activity / serine-type endopeptidase activityProcessesprotein processing / proteolysisComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Serine-type endopeptidase activity
- Specific Function
- Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
- Pfam Domain Function
- Transmembrane Regions
- 94-114 142-162 169-189 192-212 223-245 250-272
- Cellular Location
- Cell inner membrane
- Gene sequence
>lcl|BSEQ0017260|Rhomboid protease GlpG (glpG) ATGTTGATGATTACCTCTTTTGCTAACCCCCGCGTGGCGCAGGCGTTTGTTGATTACATG GCGACGCAGGGTGTTATCCTCACGATTCAACAACATAACCAAAGCGATGTCTGGCTGGCG GATGAGTCCCAGGCCGAGCGCGTACGGGCGGAGCTGGCGCGTTTTCTCGAAAACCCGGCA GATCCGCGTTATCTGGCGGCGAGCTGGCAGGCAGGCCATACCGGCAGTGGCCTGCATTAT CGCCGTTATCCTTTCTTTGCCGCCTTGCGTGAACGCGCAGGTCCGGTAACCTGGGTGATG ATGATCGCCTGCGTGGTGGTGTTTATTGCCATGCAAATTCTCGGCGATCAGGAAGTGATG TTATGGCTGGCCTGGCCATTCGATCCAACACTGAAATTTGAGTTCTGGCGTTACTTCACC CACGCGTTAATGCACTTCTCGCTGATGCATATCCTCTTTAACCTGCTCTGGTGGTGGTAT CTCGGCGGTGCGGTGGAAAAACGCCTCGGTAGCGGTAAGCTAATTGTCATTACGCTTATC AGCGCCCTGTTAAGCGGCTATGTGCAGCAAAAATTCAGCGGGCCGTGGTTTGGCGGGCTT TCTGGCGTGGTGTATGCGCTGATGGGCTACGTCTGGCTACGTGGCGAACGCGATCCGCAA AGTGGCATTTACCTGCAACGTGGGTTAATTATCTTTGCGCTGATCTGGATTGTCGCCGGA TGGTTTGATTTGTTTGGGATGTCGATGGCGAACGGAGCACACATCGCCGGGTTAGCCGTG GGTTTAGCGATGGCTTTTGTTGATTCGCTCAATGCGCGAAAACGAAAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P09391 UniProtKB Entry Name GLPG_ECOLI GenBank Protein ID 146191 GenBank Gene ID M54940 - General References
- Choi YL, Kawase S, Nishida T, Sakai H, Komano T, Kawamukai M, Utsumi R, Kohara Y, Akiyama K: Nucleotide sequence of the glpR gene encoding the repressor for the glycerol-3-phosphate regulon of Escherichia coli K12. Nucleic Acids Res. 1988 Aug 11;16(15):7732. [Article]
- Zeng G, Ye S, Larson TJ: Repressor for the sn-glycerol 3-phosphate regulon of Escherichia coli K-12: primary structure and identification of the DNA-binding domain. J Bacteriol. 1996 Dec;178(24):7080-9. [Article]
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- Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S, Shi Y: Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol. 2006 Dec;13(12):1084-91. Epub 2006 Nov 10. [Article]
- Maegawa S, Ito K, Akiyama Y: Proteolytic action of GlpG, a rhomboid protease in the Escherichia coli cytoplasmic membrane. Biochemistry. 2005 Oct 18;44(41):13543-52. [Article]
- Daley DO, Rapp M, Granseth E, Melen K, Drew D, von Heijne G: Global topology analysis of the Escherichia coli inner membrane proteome. Science. 2005 May 27;308(5726):1321-3. [Article]
- Clemmer KM, Sturgill GM, Veenstra A, Rather PN: Functional characterization of Escherichia coli GlpG and additional rhomboid proteins using an aarA mutant of Providencia stuartii. J Bacteriol. 2006 May;188(9):3415-9. [Article]
- Maegawa S, Koide K, Ito K, Akiyama Y: The intramembrane active site of GlpG, an E. coli rhomboid protease, is accessible to water and hydrolyses an extramembrane peptide bond of substrates. Mol Microbiol. 2007 Apr;64(2):435-47. [Article]
- Wang Y, Zhang Y, Ha Y: Crystal structure of a rhomboid family intramembrane protease. Nature. 2006 Nov 9;444(7116):179-80. Epub 2006 Oct 11. [Article]
- Ben-Shem A, Fass D, Bibi E: Structural basis for intramembrane proteolysis by rhomboid serine proteases. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):462-6. Epub 2006 Dec 26. [Article]
- Wang Y, Ha Y: Open-cap conformation of intramembrane protease GlpG. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2098-102. Epub 2007 Feb 2. [Article]