Intestinal-type alkaline phosphatase

Details

Name
Intestinal-type alkaline phosphatase
Synonyms
  • 3.1.3.1
  • IAP
Gene Name
ALPI
Organism
Bovine
Amino acid sequence
>lcl|BSEQ0015731|Intestinal-type alkaline phosphatase
MQGACVLLLLGLHLQLSLGLVPVEEEDPAFWNRQAAQALDVAKKLQPIQTAAKNVILFLG
DGMGVPTVTATRILKGQMNGKLGPETPLAMDQFPYVALSKTYNVDRQVPDSAGTATAYLC
GVKGNYRTIGVSAAARYNQCKTTRGNEVTSVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADLPADAQMNGCQDIAAQLVNNMDIDVILGGGRKYMFPVGTPDPEYPDDA
SVNGVRKRKQNLVQAWQAKHQGAQYVWNRTALLQAADDSSVTHLMGLFEPADMKYNVQQD
HTKDPTLQEMTEVALRVVSRNPRGFYLFVEGGRIDHGHHDDKAYMALTEAGMFDNAIAKA
NELTSELDTLILVTADHSHVFSFGGYTLRGTSIFGLAPSKALDSKSYTSILYGNGPGYAL
GGGSRPDVNDSTSEDPSYQQQAAVPQASETHGGEDVAVFARGPQAHLVHGVEEETFVAHI
MAFAGCVEPYTDCNLPAPTTATSIPDAAHLAASPPPLALLAGAMLLLLAPTLY
Number of residues
533
Molecular Weight
57099.1
Theoretical pI
Not Available
GO Classification
Functions
alkaline phosphatase activity / magnesium ion binding / zinc ion binding
Processes
dephosphorylation
Components
anchored component of membrane / integral component of membrane / plasma membrane
General Function
Zinc ion binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell membrane
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP19111
UniProtKB Entry NamePPBI_BOVIN
General References
  1. Weissig H, Schildge A, Hoylaerts MF, Iqbal M, Millan JL: Cloning and expression of the bovine intestinal alkaline phosphatase gene: biochemical characterization of the recombinant enzyme. Biochem J. 1993 Mar 1;290 ( Pt 2):503-8. [Article]
  2. Culp JS, Hermodson M, Butler LG: The active-site and amino-terminal amino acid sequence of bovine intestinal alkaline phosphatase. Biochim Biophys Acta. 1985 Oct 18;831(3):330-4. [Article]
  3. Hua JC, Berger J, Pan YC, Hulmes JD, Udenfriend S: Partial sequencing of human adult, human fetal, and bovine intestinal alkaline phosphatases: comparison with the human placental and liver isozymes. Proc Natl Acad Sci U S A. 1986 Apr;83(8):2368-72. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails