Octanoyltransferase
Details
- Name
- Octanoyltransferase
- Synonyms
- 2.3.1.181
- Lipoate-protein ligase B
- Lipoyl/octanoyl transferase
- Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
- Gene Name
- lipB
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051229|Octanoyltransferase MTGSIRSKLSAIDVRQLGTVDYRTAWQLQRELADARVAGGADTLLLLEHPAVYTAGRRTE THERPIDGTPVVDTDRGGKITWHGPGQLVGYPIIGLAEPLDVVNYVRRLEESLIQVCADL GLHAGRVDGRSGVWLPGRPARKVAAIGVRVSRATTLHGFALNCDCDLAAFTAIVPCGISD AAVTSLSAELGRTVTVDEVRATVAAAVCAALDGVLPVGDRVPSHAVPSPL
- Number of residues
- 230
- Molecular Weight
- 24210.415
- Theoretical pI
- Not Available
- GO Classification
- Functionslipoyl(octanoyl) transferase activity / octanoyltransferase activityProcessesgrowth / lipoate biosynthetic process / protein lipoylationComponentscytoplasm / plasma membrane
- General Function
- Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
- Specific Function
- Lipoyl(octanoyl) transferase activity
- Pfam Domain Function
- BPL_LplA_LipB (PF03099)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051230|Octanoyltransferase (lipB) GTGACGGGTTCTATCCGGTCGAAGCTGTCCGCGATCGACGTCCGCCAGCTGGGGACCGTC GACTACCGGACCGCGTGGCAGCTACAGCGAGAGCTAGCCGACGCCCGGGTCGCCGGCGGC GCCGACACGCTGCTGCTGTTGGAACACCCCGCGGTCTACACCGCCGGACGGCGTACCGAG ACACACGAGCGACCCATTGACGGCACTCCGGTCGTCGACACCGACCGCGGCGGCAAGATC ACCTGGCACGGTCCGGGGCAATTGGTCGGCTACCCGATCATCGGGCTGGCCGAACCCCTC GACGTGGTCAATTACGTTCGGCGCCTTGAAGAATCGCTGATCCAAGTCTGCGCCGATCTG GGCCTGCACGCCGGCCGCGTCGACGGCCGGTCCGGGGTCTGGCTGCCCGGCAGGCCGGCG CGCAAGGTCGCGGCCATCGGTGTCCGGGTGTCGCGGGCGACGACACTGCACGGGTTTGCG CTCAACTGCGATTGTGATTTGGCTGCCTTCACCGCCATCGTGCCATGCGGAATCAGTGAC GCCGCAGTGACATCGCTGTCCGCCGAACTCGGCCGTACGGTCACCGTCGACGAGGTCCGC GCGACGGTCGCCGCCGCTGTCTGCGCCGCTCTGGACGGCGTCCTACCGGTCGGTGACCGC GTGCCCTCACACGCCGTACCATCGCCGTTATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WK83 UniProtKB Entry Name LIPB_MYCTU - General References
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
- Ma Q, Zhao X, Nasser Eddine A, Geerlof A, Li X, Cronan JE, Kaufmann SH, Wilmanns M: The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8662-7. Epub 2006 May 30. [Article]