Ephrin type-A receptor 7
Details
- Name
- Ephrin type-A receptor 7
- Synonyms
- 2.7.10.1
- EHK-3
- EHK3
- EK11
- EPH homology kinase 3
- EPH-like kinase 11
- HEK11
- Gene Name
- EPHA7
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007883|Ephrin type-A receptor 7 MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISG LDENYTPIRTYQVCQVMEPNQNNWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLGTCK ETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKK GFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEE EAENAPRMHCSAEGEWLVPIGKCICKAGYQQKGDTCEPCGRGFYKSSSQDLQCSRCPTHS FSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGR NDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNG VSDLSRSQRLFAAVSITTGQAAPSQVSGVMKERVLQRSVELSWQEPEHPNGVITEYEIKY YEKDQRERTYSTVKTKSTSASINNLKPGTVYVFQIRAFTAAGYGNYSPRLDVATLEEATG KMFEATAVSSEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHF KFPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDV AVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALD AFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLS RVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDM SNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPNSL KTPLGTCSRPISPLLDQNTPDFTTFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTI EDVMSLGITLVGHQKKIMSSIQTMRAQMLHLHGTGIQV
- Number of residues
- 998
- Molecular Weight
- 112095.765
- Theoretical pI
- 5.55
- GO Classification
- FunctionsATP binding / axon guidance receptor activity / chemorepellent activity / GPI-linked ephrin receptor activity / protein tyrosine kinase activityProcessesaxon guidance / brain development / branching morphogenesis of a nerve / collateral sprouting / ephrin receptor signaling pathway / negative chemotaxis / negative regulation of collateral sprouting / negative regulation of phosphatidylinositol 3-kinase signaling / negative regulation of synapse assembly / nephric duct morphogenesis / peptidyl-tyrosine phosphorylation / phosphorylation / positive regulation of neuron apoptotic process / regulation of cell-cell adhesion / regulation of cysteine-type endopeptidase activity involved in apoptotic process / regulation of ERK1 and ERK2 cascade / regulation of peptidyl-tyrosine phosphorylation / regulation of protein autophosphorylation / retinal ganglion cell axon guidanceComponentsdendrite / integral component of plasma membrane / neuromuscular junction / neuronal cell body / plasma membrane / postsynaptic membrane
- General Function
- Protein tyrosine kinase activity
- Specific Function
- Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
- Pfam Domain Function
- Transmembrane Regions
- 556-576
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0021382|Ephrin type-A receptor 7 (EPHA7) ATGGTTTTTCAAACTCGGTACCCTTCATGGATTATTTTATGCTACATCTGGCTGCTCCGC TTTGCACACACAGGGGAGGCGCAGGCTGCGAAGGAAGTACTACTGCTGGATTCTAAAGCA CAACAAACAGAGTTGGAGTGGATTTCCTCTCCACCCAATGGGTGGGAAGAAATTAGTGGT TTGGATGAGAACTATACCCCGATACGAACATACCAGGTGTGCCAAGTCATGGAGCCCAAC CAAAACAACTGGCTGCGGACTAACTGGATTTCCAAAGGCAATGCACAAAGGATTTTTGTA GAATTGAAATTCACCCTGAGGGATTGTAACAGTCTTCCTGGAGTACTGGGAACTTGCAAG GAAACATTTAATTTGTACTATTATGAAACAGACTATGACACTGGCAGGAATATAAGAGAA AACCTCTATGTAAAAATAGACACCATTGCTGCAGATGAAAGTTTTACCCAAGGTGACCTT GGTGAAAGAAAGATGAAGCTTAACACTGAGGTGAGAGAGATTGGACCTTTGTCCAAAAAG GGATTCTATCTTGCCTTTCAGGATGTAGGGGCTTGCATAGCTTTGGTTTCTGTCAAAGTG TACTACAAGAAGTGCTGGTCCATTATTGAGAACTTAGCTATCTTTCCAGATACAGTGACT GGTTCAGAATTTTCCTCTTTAGTCGAGGTTCGAGGGACATGTGTCAGCAGTGCAGAGGAA GAAGCGGAAAACGCCCCCAGGATGCACTGCAGTGCAGAAGGAGAATGGTTAGTGCCCATT GGAAAATGTATCTGCAAAGCAGGCTACCAGCAAAAAGGAGACACTTGTGAACCCTGTGGC CGTGGGTTCTACAAGTCTTCCTCTCAAGATCTTCAGTGCTCTCGTTGTCCAACTCACAGT TTTTCTGATAAAGAAGGCTCCTCCAGATGTGAATGTGAAGATGGGTATTACAGGGCTCCA TCTGACCCACCATACGTTGCGTGCACAAGGCCTCCATCTGCACCACAGAACCTCATTTTC AACATCAACCAAACCACAGTAAGTTTGGAATGGAGTCCTCCTGCAGACAATGGGGGAAGA AACGATGTGACCTACAGAATATTGTGTAAGCGGTGCAGTTGGGAGCAGGGCGAATGTGTT CCCTGTGGGAGTAACATTGGATACATGCCCCAGCAGACTGGATTAGAGGATAACTATGTC ACTGTCATGGACCTGCTAGCCCACGCTAATTATACTTTTGAAGTTGAAGCTGTAAATGGA GTTTCTGACTTAAGCCGATCCCAGAGGCTCTTTGCTGCTGTCAGTATCACCACTGGTCAA GCAGCTCCCTCGCAAGTGAGTGGAGTAATGAAGGAGAGAGTACTGCAGCGGAGTGTCGAG CTTTCCTGGCAGGAACCAGAGCATCCCAATGGAGTCATCACAGAATATGAAATCAAGTAT TACGAGAAAGATCAAAGGGAACGGACCTACTCAACAGTAAAAACCAAGTCTACTTCAGCC TCCATTAATAATCTGAAACCAGGAACAGTGTATGTTTTCCAGATTCGGGCTTTTACTGCT GCTGGTTATGGAAATTACAGTCCCAGACTTGATGTTGCTACACTAGAGGAAGCTACAGCT ACAGCTGTCTCCAGTGAACAGAATCCTGTTATTATCATTGCTGTGGTTGCTGTAGCTGGG ACCATCATTTTGGTGTTCATGGTCTTTGGCTTCATCATTGGGAGAAGGCACTGTGGTTAT AGCAAAGCTGACCAAGAAGGCGATGAAGAGCTTTACTTTCATTTTAAATTTCCAGGCACC AAAACCTACATTGACCCTGAAACCTATGAGGACCCAAATAGAGCTGTCCATCAATTCGCC AAGGAGCTAGATGCCTCCTGTATTAAAATTGAGCGTGTGATTGGTGCAGGAGAATTCGGT GAAGTCTGCAGTGGCCGTTTGAAACTTCCAGGGAAAAGAGATGTTGCAGTAGCCATAAAA ACCCTGAAAGTTGGTTACACAGAAAAACAAAGGAGAGACTTTTTGTGTGAAGCAAGCATC ATGGGGCAGTTTGACCACCCGAATGTTGTCCATTTGGAAGGGGTTGTTACAAGAGGGAAA CCAGTCATGATAGTAATAGAGTTCATGGAAAATGGAGCCCTAGATGCATTTCTCAGGAAA CATGATGGGCAATTTACAGTCATTCAGTTAGTAGGAATGCTGAGAGGAATTGCTGCTGGA ATGAGATATTTGGCTGATATGGGATATGTTCACAGGGACCTTGCAGCTCGCAATATTCTT GTCAACAGCAATCTCGTTTGTAAAGTGTCAGATTTTGGCCTGTCCCGAGTTATAGAGGAT GATCCAGAAGCTGTCTATACAACTACTGGTGGAAAAATTCCAGTAAGGTGGACAGCACCC GAAGCCATCCAGTACCGGAAATTCACATCAGCCAGTGATGTATGGAGCTATGGAATAGTC ATGTGGGAAGTTATGTCTTATGGAGAAAGACCTTATTGGGACATGTCAAATCAAGATGTT ATAAAAGCAATAGAAGAAGGTTATCGTTTACCAGCACCCATGGACTGCCCAGCTGGCCTT CACCAGCTAATGTTGGATTGTTGGCAAAAGGAGCGTGCTGAAAGGCCAAAATTTGAACAG ATAGTTGGAATTCTAGACAAAATGATTCGAAACCCAAATAGTCTGAAAACTCCCCTGGGA ACTTGTAGTAGGCCAATAAGCCCTCTTCTGGATCAAAACACTCCTGATTTCACTACCTTT TGTTCAGTTGGAGAATGGCTACAAGCTATTAAGATGGAAAGATATAAAGATAATTTCACG GCAGCTGGCTACAATTCCCTTGAATCAGTAGCCAGGATGACTATTGAGGATGTGATGAGT TTAGGGATCACACTGGTTGGTCATCAAAAGAAAATCATGAGCAGCATTCAGACTATGAGA GCACAAATGCTACATTTACATGGAACTGGCATTCAAGTGTGA
- Chromosome Location
- 6
- Locus
- 6q16.1
- External Identifiers
Resource Link UniProtKB ID Q15375 UniProtKB Entry Name EPHA7_HUMAN GenBank Protein ID 551608 GenBank Gene ID L36642 HGNC ID HGNC:3390 - General References
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