Cytochrome P450 26C1
Details
- Name
- Cytochrome P450 26C1
- Synonyms
- 1.14.-.-
- Gene Name
- CYP26C1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049799|Cytochrome P450 26C1 MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG ETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQS AHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVS VYDASKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRAR DQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSARELGHEPSMQELKESAVELLFAAFFT TASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSL AALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAV YRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTA RWELATPAFPAMQTVPIVHPVDGLRLFFHPLTPSVAGNGLCL
- Number of residues
- 522
- Molecular Weight
- 57110.385
- Theoretical pI
- Not Available
- GO Classification
- Functionsheme binding / iron ion binding / retinoic acid 4-hydroxylase activity / retinoic acid bindingProcessesanterior/posterior pattern specification / central nervous system development / negative regulation of retinoic acid receptor signaling pathway / neural crest cell development / organelle fusion / oxidation-reduction process / retinoic acid catabolic process / sterol metabolic process / vitamin metabolic processComponentsendoplasmic reticulum membrane / integral component of membrane
- General Function
- Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).
- Specific Function
- Heme binding
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- 9-29
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0049800|Cytochrome P450 26C1 (CYP26C1) ATGTTCCCTTGGGGGCTGAGCTGCCTGTCAGTGCTGGGGGCGGCGGGCACTGCTCTCCTG TGCGCGGGCCTGCTGCTCAGCCTGGCCCAGCACCTCTGGACCCTCCGCTGGATGCTGAGC CGGGACCGGGCCTCCACCCTGCCTCTGCCCAAGGGCTCCATGGGGTGGCCCTTCTTCGGC GAAACGCTGCACTGGTTAGTTCAGGGCTCGCGCTTCCACAGTTCTCGCCGAGAGCGCTAT GGGACAGTGTTCAAGACGCACCTGCTGGGCAGGCCAGTGATCCGCGTGAGCGGCGCGGAG AACGTGCGCACCATCCTGCTGGGCGAGCACCGCCTGGTGCGCAGCCAGTGGCCGCAGAGT GCGCACATCCTGCTGGGCTCGCACACACTGCTAGGTGCGGTCGGCGAGCCGCACCGGCGG CGGCGCAAGGTCCTGGCGCGCGTGTTCAGCCGCGCCGCGCTGGAGCGCTACGTGCCGCGC CTGCAGGGGGCGCTGCGGCATGAGGTGCGCTCCTGGTGCGCGGCGGGCGGGCCGGTCTCA GTCTACGACGCCTCCAAAGCGCTCACCTTCCGCATGGCCGCGCGCATCCTGCTGGGGTTG CGGCTGGACGAGGCGCAGTGCGCCACGCTGGCCCGGACCTTCGAGCAGCTCGTGGAGAAC CTCTTCTCACTGCCTCTGGACGTTCCCTTCAGTGGCCTACGCAAGGGCATCCGGGCAAGG GACCAGCTGCATCGGCACCTGGAGGGGGCCATTTCTGAGAAGCTTCACGAGGACAAGGCT GCAGAGCCGGGTGATGCCCTCGACCTAATCATTCACAGTGCAAGGGAGCTGGGCCATGAG CCCTCCATGCAGGAGCTGAAGGAGTCGGCTGTGGAGCTCCTCTTCGCCGCCTTCTTCACC ACGGCCAGTGCCAGCACCTCGCTCGTCCTGCTGCTACTGCAGCATCCGGCGGCCATCGCC AAGATTCGGGAGGAGCTGGTGGCGCAGGGGCTGGGGCGCGCGTGCGGCTGCGCGCCCGGG GCCGCTGGGGGCAGCGAGGGGCCCCCGCCCGACTGCGGCTGCGAGCCCGACCTCAGCCTC GCGGCGCTGGGCCGTCTGCGCTACGTCGACTGCGTGGTCAAGGAGGTGCTGCGCCTCCTG CCGCCAGTGTCCGGGGGCTACCGCACCGCCCTGCGCACCTTCGAGCTCGACGGCTACCAG ATCCCCAAGGGCTGGAGCGTGATGTATAGCATCCGGGACACGCACGAGACGGCTGCGGTG TACCGCAGCCCTCCCGAAGGCTTCGATCCAGAGCGCTTCGGCGCAGCGCGCGAAGATTCC CGGGGCGCCTCCAGCCGCTTCCATTACATCCCGTTCGGCGGCGGTGCGCGCAGCTGCCTC GGCCAGGAGCTGGCGCAAGCCGTGCTCCAGCTGCTAGCTGTGGAGCTAGTGCGCACCGCG CGCTGGGAACTGGCCACACCCGCCTTCCCCGCCATGCAGACGGTGCCCATCGTGCACCCA GTGGACGGGCTGCGGCTCTTTTTCCACCCCCTCACGCCTTCGGTTGCGGGGAATGGGCTA TGCCTCTGA
- Chromosome Location
- 10
- Locus
- 10q23.33
- External Identifiers
Resource Link UniProtKB ID Q6V0L0 UniProtKB Entry Name CP26C_HUMAN HGNC ID HGNC:20577 - General References
- Taimi M, Helvig C, Wisniewski J, Ramshaw H, White J, Amad M, Korczak B, Petkovich M: A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid. J Biol Chem. 2004 Jan 2;279(1):77-85. Epub 2003 Oct 7. [Article]
- Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [Article]
- Slavotinek AM, Mehrotra P, Nazarenko I, Tang PL, Lao R, Cameron D, Li B, Chu C, Chou C, Marqueling AL, Yahyavi M, Cordoro K, Frieden I, Glaser T, Prescott T, Morren MA, Devriendt K, Kwok PY, Petkovich M, Desnick RJ: Focal facial dermal dysplasia, type IV, is caused by mutations in CYP26C1. Hum Mol Genet. 2013 Feb 15;22(4):696-703. doi: 10.1093/hmg/dds477. Epub 2012 Nov 16. [Article]