Parasympathomimetics
- Name
- Parasympathomimetics
- Accession Number
- DBCAT000448
- Description
Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.
- ATC Classification
- Drugs
Drug Drug Description Cevimeline A muscarinic agonist with parasympathomimetic activities that is used for the symptomatic treatment of dry mouth in patients with Sjögren's Syndrome. Bethanechol A muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention. Ambenonium A cholinesterase inhibitor that targets both muscarinic and nicotinic receptors indicated for the treatment of myasthenia gravis. Neostigmine A cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone. Echothiophate An acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma. Aceclidine Aceclidine has been marketed in Europe but has not been used clinically in the United States. It is used in the treatment of open-angle glaucoma and is a parasympathomimetic agent. Tacrine For the palliative treatment of mild to moderate dementia of the Alzheimer's type. Galantamine A cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. Methacholine A parasympathomimetic bronchoconstrictor used during the bronchial challenge test for the diagnosis of bronchial hyperreactivity in subjects who do not have clinically apparent asthma. Carbamoylcholine A direct acting miotic agent administered ophthalmically to decrease intraocular pressure in glaucoma or after eye surgery, and to induce miosis during surgery. Pyridostigmine A cholinesterase inhibitor used to treat myasthenia gravis. Demecarium For the topical treatment of chronic open-angle glaucoma. Pilocarpine A muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy. Acetylcholine A parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. Choline alfoscerate A component of phosphatidylcholines (lecithins), in which the two hydroxy groups of glycerol are esterified with fatty acids. (From Stedman, 26th ed) It counteracts the effects of urea on enzymes... Paraoxon Not Annotated Distigmine Distigmine is a parasympathomimetic agent with a longer duration of action and enhanced drug accumulation compared to DB00545 and DB01400. It is an anticholinergic drug and long-acting reversible carbamate cholinesterase... Physostigmine A cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity. Xanomeline Xanomeline is under investigation in clinical trial NCT02831231 (Pilot Study Comparing Effects of Xanomeline Alone to Xanomeline Plus Trospium). - Drugs & Drug Targets