Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.
DrugDrug NameDrug Indication
DB00185CevimelineFor the treatment of symptoms of dry mouth in patients with Sjögren's Syndrome.
DB01019BethanecholFor the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention.
DB01122AmbenoniumAmbenonium is used to treat muscle weakness due to muscle disease (myasthenia gravis).
DB01400NeostigmineNeostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.
DB01057EchothiophateFor use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.
DB00411CarbacholPrimarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
DB00545PyridostigmineFor the treatment of myasthenia gravis.
DB00944DemecariumFor the topical treatment of chronic open-angle glaucoma.
DB01085PilocarpineFor the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.
DB03128AcetylcholineUsed to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.
DB04660Choline alfoscerateNot Available
DB13694DistigmineNot Available
DB00382TacrineFor the palliative treatment of mild to moderate dementia of the Alzheimer's type.
DB00674GalantamineFor the treatment of mild to moderate dementia of the Alzheimer's type. Has also been investigated in patients with mild cognitive impairment who did not meet the diagnostic criteria for Alzheimer's disease.
DB06709MethacholineIt is most commonly used for diagnosing bronchial hyperreactivity, using the bronchial challenge test.
DrugDrug NameTargetType
DB00185CevimelineMuscarinic acetylcholine receptor M1target
DB00185CevimelineMuscarinic acetylcholine receptor M3target
DB00185CevimelineCytochrome P450 3A4enzyme
DB00185CevimelineCytochrome P450 2D6enzyme
DB00185CevimelineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB01019BethanecholMuscarinic acetylcholine receptor M2target
DB01019BethanecholMuscarinic acetylcholine receptor M1target
DB01019BethanecholMuscarinic acetylcholine receptor M3target
DB01019BethanecholMuscarinic acetylcholine receptor M4target
DB01122AmbenoniumAcetylcholinesterasetarget
DB01122AmbenoniumCholinesteraseenzyme
DB01400NeostigmineAcetylcholinesterasetarget
DB01400NeostigmineCholinesteraseenzyme
DB01400NeostigmineMultidrug resistance protein 1transporter
DB01057EchothiophateCholinesterasetarget
DB01057EchothiophateSerum albumincarrier
DB00411CarbacholMuscarinic acetylcholine receptor M1target
DB00411CarbacholMuscarinic acetylcholine receptor M2target
DB00411CarbacholNeuronal acetylcholine receptor subunit alpha-2target
DB00411CarbacholCytosolic phospholipase A2enzyme
DB00411CarbacholAcetylcholinesterasetarget
DB00411CarbacholMuscarinic acetylcholine receptor M3target
DB00411CarbacholMuscarinic acetylcholine receptor M4target
DB00545PyridostigmineAcetylcholinesterasetarget
DB00545PyridostigmineCytochrome P450 3A4enzyme
DB00545PyridostigmineCholinesterasetarget
DB00545PyridostigmineSerum albumintarget
DB00944DemecariumAcetylcholinesterasetarget
DB00944DemecariumCholinesterasetarget
DB01085PilocarpineMuscarinic acetylcholine receptor M1target
DB01085PilocarpineMuscarinic acetylcholine receptor M2target
DB01085PilocarpineCytochrome P450 2A6enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M3target
DB01085PilocarpineCytochrome P450 2E1enzyme
DB01085PilocarpineCytochrome P450 3A4enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M4target
DB03128AcetylcholineAcetylcholinesterasetarget
DB03128AcetylcholineSolute carrier family 22 member 5transporter
DB03128AcetylcholineSolute carrier family 22 member 1transporter
DB03128AcetylcholineCytochrome P450 2D6enzyme
DB03128AcetylcholineMuscarinic acetylcholine receptor M1target
DB03128AcetylcholineMuscarinic acetylcholine receptor M2target
DB03128AcetylcholineMuscarinic acetylcholine receptor M3target
DB03128AcetylcholineMuscarinic acetylcholine receptor M4target
DB03128AcetylcholineNeuronal acetylcholine receptor subunit alpha-7target
DB04660Choline alfoscerateGanglioside GM2 activatortarget
DB00382TacrineAcetylcholinesterasetarget
DB00382TacrineCytochrome P450 1A2enzyme
DB00382TacrineCholinesterasetarget
DB00382TacrineMultidrug resistance protein 1transporter
DB00382TacrineLiver carboxylesterase 1target
DB00674GalantamineAcetylcholinesterasetarget
DB00674GalantamineCytochrome P450 3A4enzyme
DB00674GalantamineCytochrome P450 2D6enzyme
DB00674GalantamineAcetylcholine receptor subunit alphatarget
DB00674GalantamineAcetylcholine receptor subunit betatarget
DB00674GalantamineAcetylcholine receptor subunit deltatarget
DB00674GalantamineAcetylcholine receptor subunit gammatarget
DB00674GalantamineAcetylcholine receptor subunit epsilontarget
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-2target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-3target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-4target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-5target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-6target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-7target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-9target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-10target
DB00674GalantamineNeuronal acetylcholine receptor subunit beta-2target
DB00674GalantamineNeuronal acetylcholine receptor subunit beta-3target
DB00674GalantamineNeuronal acetylcholine receptor subunit beta-4target
DB00674GalantamineCholinesterasetarget
DB06709MethacholineMuscarinic acetylcholine receptor M3target