Progestins

Name
Progestins
Accession Number
DBCAT000708
Description

Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY.

ATC Classification
Drugs
DrugDrug Description
AllylestrenolAllylestrenol was designed to be used for miscarriage prevention, prevention of premature labour and has been investigated for possible use in men for treatment for benign prostatic hyperplasia.
EtonogestrelA long-acting synthetic derived progestin contraceptive used in various devices such as contraceptive rings and intradermal implants.
Medroxyprogesterone acetateA progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty.
ProgesteroneA hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia.
NorethisteroneA synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis.
Hydroxyprogesterone caproateA synthetic progestin used for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth.
DesogestrelA synthetic progestin used in contraception, often in combination with ethinyl estradiol.
DydrogesteroneUsed to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history...
GestodeneGestodene is a progestogen hormonal contraceptive. Products containing gestoden include Meliane, which contains 20 mcg of ethinylestradiol and 75 mcg of gestodene; and Gynera, which contains 30 mcg of ethinylestradiol...
AltrenogestAltrenogest, also known as allyltrenbolone, is a steroidal progestin that is widely used in veterinary medicine to suppress estrus in animals.
GestrinoneEndometriosis with or without accompanying sterility. Treatment is limited to a single course of 6 months duration per lifetime [L1699, L1700].
MedrogestoneA progestin used as an adjunct to control secondary amenorrhea and dysfunctional bleeding in adolescent and adult females, and treat endometrial shedding in menopausal women.
NomegestrolNomegestrol is an ingredient in the EMA-authorised product Zoely.
GestonoroneGestonorone is often mistaken for gestonorone capproate which has a different chemical structure.
MethylestrenoloneNot Annotated
NorgestrienoneNot Annotated
PromegestoneNot Annotated
DemegestoneDemegestone is a progesterone receptor agonist that was previously used to treat luteal insufficiency. It was previously marketed in France as Lutionex, but has since been discontinued.
Megestrol acetateA progestin that is administered orally to treat anorexia and cachexia or serious unexplained weight loss and is also used as an antineoplastic agent to treat certain types of malignancy.
LevonorgestrelA progestin found in oral and IUD contraceptives and at higher doses in emergency contraceptives.
DienogestAn oral progestin used for the treatment of endometriosis as monotherapy or contraception in combination with ethinylestradiol.
DrospirenoneA progestin used in oral contraceptive pills for the prevention of pregnancy and other conditions.
LynestrenolLynestrenol has been used in trials studying the basic science of Transsexualism and Gender Dysphoria.
ChlormadinoneNot Annotated
QuingestanolNot Annotated
EtynodiolEtynodiol (INN), or ethynodiol (BAN) is a steroidal progestin related to norethisterone which was never marketed. While etynodiol is sometimes used as a synonym for etynodiol diacetate, it usually refers...
NorgestrelA progestin used in combination with ethinyl estradiol for oral contraception and prevention of pregnancy in women.
NorgestimateA progesterone used as a contraceptive and to treat acne vulgaris.
NorethynodrelA synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it...
NorelgestrominA progestin used for the prevention of pregnancy in women who elect to use a transdermal patch as a method of contraception.
Nomegestrol acetateNomegestrol acetate, also known as NOMAC, is a progestin used in oral contraceptives, menopausal hormone therapy, and for the treatment of gynecological disorders.
Ethynodiol diacetateAn oral contraceptive used to prevent pregnancy.
Cyproterone acetateA steroid used in combination with ethinyl estradiol to treat women with severe acne and symptoms of androgenization. Also used alone at much higher doses for palliative treatment of patients with prostate cancer
HydroxyprogesteroneNot Annotated
Norethindrone enanthateNot Annotated
Quingestanol acetateNot Annotated
Drugs & Drug Targets
DrugTargetType
AllylestrenolProgesterone receptortarget
AllylestrenolEstrogen receptor alphatarget
EtonogestrelProgesterone receptortarget
EtonogestrelCytochrome P450 3A4enzyme
EtonogestrelSerum albumincarrier
EtonogestrelSex hormone-binding globulincarrier
Medroxyprogesterone acetateProgesterone receptortarget
Medroxyprogesterone acetateEstrogen receptor alphatarget
Medroxyprogesterone acetateCytochrome P450 3A4enzyme
Medroxyprogesterone acetateCytochrome P450 2C8enzyme
Medroxyprogesterone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
Medroxyprogesterone acetateCytochrome P450 2C9enzyme
Medroxyprogesterone acetateCytochrome P450 3A1enzyme
Medroxyprogesterone acetateSerum albumincarrier
Medroxyprogesterone acetateP-glycoprotein 1target
Medroxyprogesterone acetateGABA(A) Receptortarget
Medroxyprogesterone acetateP-glycoprotein 1transporter
ProgesteroneProgesterone receptortarget
ProgesteroneEstrogen receptor alphatarget
ProgesteroneSteroid 17-alpha-hydroxylase/17,20 lyasetarget
ProgesteroneCytochrome P450 2C19enzyme
ProgesteroneCytochrome P450 2C9enzyme
ProgesteroneCytochrome P450 3A4enzyme
ProgesteroneCytochrome P450 3A5enzyme
ProgesteroneCytochrome P450 3A7enzyme
ProgesteroneP-glycoprotein 1transporter
ProgesteroneSolute carrier family 22 member 2transporter
ProgesteroneSolute carrier family 22 member 1transporter
ProgesteroneSolute carrier family 22 member 3transporter
ProgesteroneBile salt export pumptransporter
ProgesteroneMultidrug resistance-associated protein 1transporter
ProgesteroneSodium/bile acid cotransportertransporter
ProgesteroneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
ProgesteroneCytochrome P450 1A1enzyme
ProgesteroneCytochrome P450 1B1enzyme
ProgesteroneCytochrome P450 2A6enzyme
ProgesteroneCytochrome P450 2D6enzyme
ProgesteroneMineralocorticoid receptortarget
ProgesteroneKappa-type opioid receptortarget
ProgesteroneAlpha-1-acid glycoprotein 1target
ProgesteroneGlucocorticoid receptortarget
ProgesteroneAndrogen receptortarget
ProgesteroneSex hormone-binding globulintarget
ProgesteroneSolute carrier organic anion transporter family member 1B1transporter
ProgesteroneATP-binding cassette sub-family G member 2transporter
ProgesteroneEstrogen receptor betatarget
ProgesteroneSolute carrier organic anion transporter family member 1B3transporter
NorethisteroneProgesterone receptortarget
NorethisteroneP-glycoprotein 1transporter
NorethisteroneCytochrome P450 2C19enzyme
NorethisteroneSerum albumincarrier
NorethisteroneSex hormone-binding globulincarrier
NorethisteroneAldo-keto reductase family 1 member C4enzyme
Norethisterone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
Norethisterone3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Norethisterone3-oxo-5-beta-steroid 4-dehydrogenaseenzyme
NorethisteroneCytochrome P450 3A4enzyme
NorethisteroneCytochrome P450 1A2enzyme
NorethisteroneCytochrome P450 2A6enzyme
NorethisteroneGlucocorticoid receptortarget
NorethisteroneAndrogen receptortarget
Hydroxyprogesterone caproateProgesterone receptortarget
Hydroxyprogesterone caproateCytochrome P450 3A4enzyme
Hydroxyprogesterone caproateCytochrome P450 3A5enzyme
Hydroxyprogesterone caproateCytochrome P450 2C19enzyme
DesogestrelProgesterone receptortarget
DesogestrelEstrogen receptor alphatarget
DesogestrelCytochrome P450 3A4enzyme
DesogestrelSerum albumincarrier
DesogestrelSex hormone-binding globulincarrier
DesogestrelCytochrome P450 2C9enzyme
DesogestrelUDP-glucuronosyltransferase 1-1enzyme
DydrogesteroneProgesterone receptortarget
DydrogesteroneCytochrome P450 3A4enzyme
GestodeneCytochrome P450 3A5enzyme
GestodeneCytochrome P450 3A7enzyme
GestodeneProgesterone receptortarget
GestodeneCytochrome P450 3A4enzyme
GestodeneCytochrome P450 2C19enzyme
GestrinoneSex hormone-binding globulintarget
GestrinoneProgesterone receptortarget
GestrinoneGlucocorticoid receptortarget
GestrinoneAndrogen receptortarget
GestrinoneGonadotropin-releasing hormone receptortarget
GestrinoneEstrogen receptor alphatarget
GestrinoneCytochrome P450 3A4enzyme
MedrogestoneSerum albumincarrier
MedrogestoneProgesterone receptortarget
MedrogestoneSex hormone-binding globulincarrier
MedrogestoneCorticosteroid-binding globulincarrier
MedrogestoneCytochrome P450 3A4enzyme
NomegestrolCytochrome P450 3A4enzyme
PromegestoneCytochrome P450 3A4enzyme
DemegestoneProgesterone receptortarget
DemegestoneCytochrome P450 3A4enzyme
Megestrol acetateProgesterone receptortarget
Megestrol acetateGlucocorticoid receptortarget
Megestrol acetateP-glycoprotein 1transporter
Megestrol acetateCytochrome P450 3A4enzyme
LevonorgestrelProgesterone receptortarget
LevonorgestrelEstrogen receptor alphatarget
Levonorgestrel3-oxo-5-alpha-steroid 4-dehydrogenase 1target
LevonorgestrelCytochrome P450 3A4enzyme
LevonorgestrelAndrogen receptortarget
LevonorgestrelSex hormone-binding globulintarget
LevonorgestrelGlucocorticoid receptortarget
LevonorgestrelCytochrome P450 3A5enzyme
DienogestCytochrome P450 3A4enzyme
DienogestProgesterone receptortarget
DienogestAndrogen receptortarget
DrospirenoneProgesterone receptortarget
DrospirenoneMineralocorticoid receptortarget
DrospirenoneAndrogen receptortarget
DrospirenoneProstaglandin G/H synthase 2enzyme
DrospirenoneSerum paraoxonase/arylesterase 1enzyme
DrospirenoneGlucocorticoid receptortarget
DrospirenoneCytochrome P450 3A4enzyme
LynestrenolCytochrome P450 3A4enzyme
LynestrenolCytochrome P450 2C9enzyme
LynestrenolCytochrome P450 2C19enzyme
ChlormadinoneCytochrome P450 3A4enzyme
QuingestanolCytochrome P450 3A4enzyme
EtynodiolCytochrome P450 3A4enzyme
NorgestrelProgesterone receptortarget
Norgestrel3-oxo-5-alpha-steroid 4-dehydrogenase 1target
NorgestrelAndrogen receptortarget
NorgestrelCytochrome P450 3A4enzyme
NorgestrelCytochrome P450 19A1enzyme
NorgestimateProgesterone receptortarget
NorgestimateEstrogen receptor alphatarget
NorgestimateCanalicular multispecific organic anion transporter 1transporter
NorgestimateCytochrome P450 3A4enzyme
NorgestimateAndrogen receptortarget
NorgestimateCytochrome P450 2B6enzyme
NorgestimateCytochrome P450 2C9enzyme
NorgestimateUDP-glucuronosyltransferase 1-1enzyme
NorgestimateSerum albumincarrier
NorgestimateSex hormone-binding globulincarrier
NorgestimateP-glycoprotein 1transporter
NorethynodrelEstrogen receptor alphatarget
NorethynodrelAndrogen receptortarget
NorethynodrelSex hormone-binding globulintarget
NorethynodrelCytochrome P450 3A4enzyme
NorelgestrominSteryl-sulfataseenzyme
NorelgestrominProgesterone receptortarget
NorelgestrominSerum albumintarget
NorelgestrominAndrogen receptortarget
NorelgestrominCytochrome P450 3A4enzyme
Nomegestrol acetateCytochrome P450 3A4enzyme
Ethynodiol diacetateEstrogen receptor alphatarget
Ethynodiol diacetateProgesterone receptortarget
Ethynodiol diacetateCytochrome P450 3A4enzyme
Cyproterone acetateAndrogen receptortarget
Cyproterone acetateProstate-specific antigentarget
Cyproterone acetateCytochrome P450 3A4enzyme
Cyproterone acetateCytochrome P450 19A1enzyme
HydroxyprogesteroneCytochrome P450 3A4enzyme
Norethindrone enanthateCytochrome P450 3A4enzyme