Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
|Drug||Drug Name||Drug Indication|
|DB00390||Digoxin||Digoxin is indicated in the following conditions: 1) For the treatment of mild to moderate heart failure in adult patients.[L6775] 2) To increase myocardial contraction in children diagnosed with heart failure.[L6775] 3) To maintain control ventricular rate in adult patients diagnosed with chronic atrial fibrillation.[L6775] In adults with heart failure, when it is clinically possible, digoxin should be administered in conjunction with a diuretic and an angiotensin-converting enzyme (ACE) inhibitor for optimum effects.[L6775]|
|DB00511||Acetyldigitoxin||Used for fast digitalization in congestive heart failure.|
|DB01078||Deslanoside||For the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure.|
|DB01092||Ouabain||For the treatment of atrial fibrillation and flutter and heart failure|
|DB01396||Digitoxin||For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.|
|DB13467||Lanatoside C||Not Available|