- Cardiac Glycosides
- Accession Number
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
- ATC Classification
Drug Drug Description Digoxin A cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. Acetyldigitoxin Used for fast digitalization in congestive heart failure. Deslanoside For the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure. Ouabain For the treatment of atrial fibrillation and flutter and heart failure Digitoxin A cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure. Cymarin Not Annotated Proscillaridin Proscillaridin is a cardiac glycoside that is derived from plants of the genus Scilla and in Drimia maritima (Scilla maritima). Studies suggest the potential cytotoxic and anticancer property of proscillaridin,... Metildigoxin Not Annotated Peruvoside Not Annotated Lanatoside C Not Annotated Gitoformate Not Annotated Acetyldigoxin Not Annotated Oleandrin Oleandrin has been used in trials studying the treatment of Lung Cancer and Chemotherapeutic Agent Toxicity. Digoxigenin Digoxigenin is a cardenolide which is the aglycon of digoxin. Can be obtained by hydrolysis of digoxin or from Digitalis orientalis L. and Digitalis lanata Ehrh. Digitoxigenin Digitoxigenin is a cardenolide which is the aglycon of digitoxin.
- Drugs & Drug Targets