Prostaglandins I

Name
Prostaglandins I
Accession Number
DBCAT001312
Description

A class of cyclic prostaglandins that contain the 6,9-epoxy bond. Endogenous members of this family are biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES.

Drugs
DrugDrug Description
EpoprostenolA vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure.
TreprostinilA prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol.
BeraprostFor the treatment of pulmonary hypertension.
Drugs & Drug Targets
DrugTargetType
EpoprostenolP2Y purinoceptor 12target
EpoprostenolProstacyclin receptortarget
EpoprostenolProstacyclin synthasetarget
TreprostinilP2Y purinoceptor 12target
TreprostinilPeroxisome proliferator-activated receptor deltatarget
TreprostinilProstacyclin receptortarget
TreprostinilCytochrome P450 2C9enzyme
TreprostinilProstaglandin E2 receptor EP2 subtypetarget
TreprostinilProstaglandin D2 receptortarget
TreprostinilCytochrome P450 2C8enzyme
BeraprostProstacyclin receptortarget
BeraprostCytochrome P450 2C8enzyme