DNA, Antisense
- Name
- DNA, Antisense
- Accession Number
- DBCAT001714
- Description
DNA that is complementary to the sense strand. (The sense strand has the same sequence as the mRNA transcript. The antisense strand is the template for mRNA synthesis.) Synthetic antisense DNAs are used to hybridize to complementary sequences in target RNAs or DNAs to effect the functioning of specific genes for investigative or therapeutic purposes.
- Drugs
Drug Drug Description Mipomersen An oligonucleotide drug used for the treatment of homozygous familial hypercholesterolemia. Oblimersen Not Annotated Inotersen An antisense oligonucleotide used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis. - Drugs & Drug Targets
Drug Target Type Mipomersen mRNA of ApoB-100 target Inotersen Transthyretin mRNA target