Antipsychotic Agents (Second Generation [Atypical])

DrugDrug NameDrug Description
DB06288AmisulprideInvestigated for use/treatment in schizophrenia and schizoaffective disorders, mania in bipolar disorder, and depression.
DB01238AripiprazoleAn atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome.
DB06216AsenapineAn atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia.
DB09223BlonanserinUsed for the treatment of schizophrenia .
DB00363ClozapineAn antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients.
DB04946IloperidoneAn atypical antipsychotic agent used for the acute treatment of schizophrenia in adults.
DB08815LurasidoneAn atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder.
DB09224MelperoneFor the treatment of schizophrenia, sleep, disorders, agitation and mentally confused states [L1317, L1319, L1322].
DB00334OlanzapineAn antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.
DB01267PaliperidoneAn atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders.
DB08922PerospironeFor the treatment of schizophrenia and acute cases of bipolar mania.
DB01224QuetiapineA psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder.
DB00734RisperidoneA second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression.
DB06144SertindoleUsed in the treatment of schizophrenia.
DB00246ZiprasidoneAn atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia.
DB09225ZotepineZotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes...
DB06016CariprazineAn atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder.
DB06077LumateperoneA novel 2nd generation antipsychotic used to manage both positive and negative symptoms in patients with schizophrenia.
DB05316PimavanserinA second generation atypical antipsychotic used for the treatment of hallucinations and delusions caused by Parkinson's Disease.
DB09226RP-5063Investigated for the treatment of schizophrenia and schizoaffective disorder.
DB09128BrexpiprazoleA serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct and schizophrenia.
DB04888BifeprunoxBifeprunox is being evaluated for the treatment of schizophrenia, psychosis, and Parkinson's disease.
DrugDrug NameTargetType
DB06288AmisulprideDopamine D2 receptortarget
DB06288AmisulprideDopamine D3 receptortarget
DB06288Amisulpride5-hydroxytryptamine receptor 7target
DB06288Amisulpride5-hydroxytryptamine receptor 2Atarget
DB01238AripiprazoleDopamine D2 receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Atarget
DB01238AripiprazoleCytochrome P450 3A4enzyme
DB01238AripiprazoleCytochrome P450 2D6enzyme
DB01238Aripiprazole5-hydroxytryptamine receptor 1Btarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Dtarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Etarget
DB01238AripiprazoleDopamine D1 receptortarget
DB01238AripiprazoleDopamine D5 receptortarget
DB01238AripiprazoleDopamine D3 receptortarget
DB01238AripiprazoleDopamine D4 receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Ctarget
DB01238Aripiprazole5-hydroxytryptamine receptor 3Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 6target
DB01238Aripiprazole5-hydroxytryptamine receptor 7target
DB01238AripiprazoleHistamine H1 receptortarget
DB01238AripiprazoleAlpha-1A adrenergic receptortarget
DB01238AripiprazoleAlpha-1B adrenergic receptortarget
DB01238AripiprazoleAlpha-2A adrenergic receptortarget
DB01238AripiprazoleAlpha-2B adrenergic receptortarget
DB01238AripiprazoleAlpha-2C adrenergic receptortarget
DB01238AripiprazoleCytochrome P450 3A5enzyme
DB01238AripiprazoleCytochrome P450 3A7enzyme
DB01238AripiprazoleSerum albumincarrier
DB01238Aripiprazole5-hydroxytryptamine receptor 2Btarget
DB01238Aripiprazole5-hydroxytryptamine receptor 5Atarget
DB01238AripiprazoleBeta-1 adrenergic receptortarget
DB01238AripiprazoleBeta-2 adrenergic receptortarget
DB01238AripiprazoleHistamine H2 receptortarget
DB01238AripiprazoleHistamine H3 receptortarget
DB01238AripiprazoleHistamine H4 receptortarget
DB01238AripiprazoleMuscarinic acetylcholine receptor M1target
DB01238AripiprazoleMuscarinic acetylcholine receptor M2target
DB01238AripiprazoleMuscarinic acetylcholine receptor M3target
DB01238AripiprazoleMuscarinic acetylcholine receptor M4target
DB01238AripiprazoleMuscarinic acetylcholine receptor M5target
DB01238AripiprazoleKappa-type opioid receptortarget
DB01238AripiprazoleMu-type opioid receptortarget
DB01238AripiprazoleDelta-type opioid receptortarget
DB01238AripiprazoleGlutamate (NMDA) receptortarget
DB01238AripiprazoleSodium-dependent dopamine transportertarget
DB01238AripiprazoleSodium-dependent serotonin transportertarget
DB06216Asenapine5-hydroxytryptamine receptor 1Atarget
DB06216Asenapine5-hydroxytryptamine receptor 1Btarget
DB06216Asenapine5-hydroxytryptamine receptor 2Atarget
DB06216Asenapine5-hydroxytryptamine receptor 2Btarget
DB06216Asenapine5-hydroxytryptamine receptor 2Ctarget
DB06216Asenapine5-hydroxytryptamine receptor 6target
DB06216Asenapine5-hydroxytryptamine receptor 7target
DB06216AsenapineAlpha-2A adrenergic receptortarget
DB06216AsenapineAlpha-2B adrenergic receptortarget
DB06216AsenapineAlpha-2C adrenergic receptortarget
DB06216AsenapineAlpha-1A adrenergic receptortarget
DB06216AsenapineDopamine D1 receptortarget
DB06216AsenapineDopamine D2 receptortarget
DB06216AsenapineDopamine D3 receptortarget
DB06216AsenapineDopamine D4 receptortarget
DB06216AsenapineHistamine H1 receptortarget
DB06216AsenapineHistamine H2 receptortarget
DB06216AsenapineCytochrome P450 1A2enzyme
DB06216AsenapineCytochrome P450 2D6enzyme
DB06216Asenapine5-hydroxytryptamine receptor 5Atarget
DB06216AsenapineUDP-glucuronosyltransferase 1-4enzyme
DB06216AsenapineCytochrome P450 3A4enzyme
DB06216AsenapineBeta-1 adrenergic receptortarget
DB06216AsenapineBeta-2 adrenergic receptortarget
DB06216AsenapineSerum albumincarrier
DB06216Asenapinealpha1-acid glycoproteincarrier
DB09223BlonanserinCytochrome P450 3A4enzyme
DB09223BlonanserinDopamine D2 receptortarget
DB09223BlonanserinDopamine D3 receptortarget
DB09223Blonanserin5-hydroxytryptamine receptor 2Atarget
DB09223BlonanserinSerum albumincarrier
DB00363ClozapineDopamine D4 receptortarget
DB00363ClozapineHistamine H1 receptortarget
DB00363ClozapineDopamine D2 receptortarget
DB00363ClozapineNeuron-specific vesicular protein calcyontarget
DB00363ClozapineHistamine H4 receptortarget
DB00363Clozapine5-hydroxytryptamine receptor 2Atarget
DB00363Clozapine5-hydroxytryptamine receptor 1Atarget
DB00363Clozapine5-hydroxytryptamine receptor 2Ctarget
DB00363ClozapineDopamine D1 receptortarget
DB00363ClozapineCytochrome P450 1A2enzyme
DB00363ClozapineCytochrome P450 2D6enzyme
DB00363ClozapineDopamine D3 receptortarget
DB00363ClozapineMuscarinic acetylcholine receptor M1target
DB00363ClozapineMuscarinic acetylcholine receptor M2target
DB00363ClozapineMuscarinic acetylcholine receptor M3target
DB00363ClozapineMuscarinic acetylcholine receptor M4target
DB00363ClozapineMuscarinic acetylcholine receptor M5target
DB00363Clozapine5-hydroxytryptamine receptor 1Btarget
DB00363Clozapine5-hydroxytryptamine receptor 1Dtarget
DB00363Clozapine5-hydroxytryptamine receptor 1Etarget
DB00363Clozapine5-hydroxytryptamine receptor 3Atarget
DB00363Clozapine5-hydroxytryptamine receptor 6target
DB00363Clozapine5-hydroxytryptamine receptor 7target
DB00363ClozapineAlpha-1A adrenergic receptortarget
DB00363ClozapineAlpha-1B adrenergic receptortarget
DB00363ClozapineAlpha-2A adrenergic receptortarget
DB00363ClozapineAlpha-2B adrenergic receptortarget
DB00363ClozapineAlpha-2C adrenergic receptortarget
DB00363ClozapineCytochrome P450 2C9enzyme
DB00363ClozapineP-glycoprotein 1transporter
DB00363ClozapineCytochrome P450 3A4enzyme
DB00363ClozapineCytochrome P450 2C19enzyme
DB00363ClozapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00363ClozapineUDP-glucuronosyltransferase 1-4enzyme
DB00363ClozapineCytochrome P450 1A1enzyme
DB00363ClozapineCytochrome P450 2A6enzyme
DB00363ClozapineCytochrome P450 2C8enzyme
DB00363ClozapineGlutathione S-transferase Ptarget
DB04946IloperidoneDopamine D2 receptortarget
DB04946Iloperidone5-hydroxytryptamine receptor 2Atarget
DB04946IloperidoneCytochrome P450 2D6enzyme
DB04946IloperidoneCytochrome P450 3A4enzyme
DB04946IloperidoneCytochrome P450 3A5enzyme
DB04946IloperidoneCytochrome P450 3A7enzyme
DB04946IloperidoneCytochrome P450 2E1enzyme
DB04946IloperidoneDopamine D3 receptortarget
DB04946IloperidoneAlpha-1A adrenergic receptortarget
DB04946IloperidoneDopamine D4 receptortarget
DB04946Iloperidone5-hydroxytryptamine receptor 6target
DB04946Iloperidone5-hydroxytryptamine receptor 7target
DB04946IloperidoneHistamine H1 receptortarget
DB04946IloperidoneDopamine D1 receptortarget
DB04946Iloperidone5-hydroxytryptamine receptor 1Atarget
DB04946IloperidoneAlpha-2C adrenergic receptortarget
DB08815LurasidoneCytochrome P450 3A4enzyme
DB08815LurasidoneDopamine D2 receptortarget
DB08815Lurasidone5-hydroxytryptamine receptor 2Atarget
DB08815Lurasidone5-hydroxytryptamine receptor 7target
DB08815Lurasidone5-hydroxytryptamine receptor 1Atarget
DB08815LurasidoneAlpha-2C adrenergic receptortarget
DB08815LurasidoneAlpha-2A adrenergic receptortarget
DB09224MelperoneDopamine D2 receptortarget
DB09224MelperoneCytochrome P450 2D6enzyme
DB00334OlanzapineDopamine D1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M1target
DB00334OlanzapineMuscarinic acetylcholine receptor M3target
DB00334Olanzapine5-hydroxytryptamine receptor 2Atarget
DB00334OlanzapineDopamine D4 receptortarget
DB00334OlanzapineHistamine H1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M4target
DB00334OlanzapineMuscarinic acetylcholine receptor M2target
DB00334OlanzapineDopamine D2 receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 2Ctarget
DB00334OlanzapineDopamine D3 receptortarget
DB00334OlanzapineAlpha-1B adrenergic receptortarget
DB00334OlanzapineCytochrome P450 1A2enzyme
DB00334Olanzapine5-hydroxytryptamine receptor 3Atarget
DB00334Olanzapine5-hydroxytryptamine receptor 6target
DB00334OlanzapineAlpha-1A adrenergic receptortarget
DB00334OlanzapineDopamine D5 receptortarget
DB00334OlanzapineSerum albumincarrier
DB00334OlanzapineAlpha-1-acid glycoprotein 1carrier
DB00334OlanzapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00334OlanzapineCytochrome P450 2D6enzyme
DB00334OlanzapineP-glycoprotein 1transporter
DB00334OlanzapineCytochrome P450 2C19enzyme
DB00334OlanzapineD(1) dopamine receptortarget
DB00334OlanzapineBeta adrenergic receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 1target
DB00334OlanzapineGABA-A receptor (benzodiazepine site)target
DB00334OlanzapineCytochrome P450 2C9enzyme
DB00334OlanzapineUDP-glucuronosyltransferase 1-4enzyme
DB00334OlanzapineCytochrome P450 3A4enzyme
DB00334OlanzapineCytochrome P450 3A Subfamilyenzyme
DB01267PaliperidoneDopamine D2 receptortarget
DB01267Paliperidone5-hydroxytryptamine receptor 2Atarget
DB01267PaliperidoneHistamine H1 receptortarget
DB01267PaliperidoneAlpha-1A adrenergic receptortarget
DB01267PaliperidoneAlpha-1B adrenergic receptortarget
DB01267PaliperidoneDopamine D3 receptortarget
DB01267PaliperidoneDopamine D4 receptortarget
DB01267PaliperidoneDopamine D1 receptortarget
DB01267PaliperidoneAlpha-2A adrenergic receptortarget
DB01267PaliperidoneAlpha-2B adrenergic receptortarget
DB01267PaliperidoneAlpha-2C adrenergic receptortarget
DB01267Paliperidone5-hydroxytryptamine receptor 1Atarget
DB01267Paliperidone5-hydroxytryptamine receptor 1Dtarget
DB01267Paliperidone5-hydroxytryptamine receptor 2Ctarget
DB01267Paliperidone5-hydroxytryptamine receptor 7target
DB01267PaliperidoneCytochrome P450 3A4enzyme
DB01267PaliperidoneCytochrome P450 2D6enzyme
DB01267PaliperidoneCytochrome P450 3A5enzyme
DB01267PaliperidoneP-glycoprotein 1transporter
DB08922Perospirone5-hydroxytryptamine receptor 2Atarget
DB08922PerospironeDopamine D2 receptortarget
DB08922Perospirone5-hydroxytryptamine receptor 1Atarget
DB08922PerospironeCytochrome P450 3A4enzyme
DB08922PerospironeCytochrome P450 2D6enzyme
DB08922PerospironeCytochrome P450 2C8enzyme
DB08922PerospironeCytochrome P450 1A1enzyme
DB08922PerospironeHistamine H1 receptortarget
DB08922PerospironeDopamine D4 receptortarget
DB08922PerospironeAlpha-1 adrenergic receptorstarget
DB01224Quetiapine5-hydroxytryptamine receptor 2Atarget
DB01224Quetiapine5-hydroxytryptamine receptor 2Ctarget
DB01224QuetiapineDopamine D2 receptortarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Atarget
DB01224QuetiapineHistamine H1 receptortarget
DB01224QuetiapineCytochrome P450 3A4enzyme
DB01224QuetiapineAlpha-1 adrenergic receptorstarget
DB01224QuetiapineAlpha-2A adrenergic receptortarget
DB01224QuetiapineAlpha-2B adrenergic receptortarget
DB01224QuetiapineAlpha-2C adrenergic receptortarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Dtarget
DB01224QuetiapineMuscarinic acetylcholine receptor M1target
DB01224QuetiapineMuscarinic acetylcholine receptor M2target
DB01224QuetiapineMuscarinic acetylcholine receptor M3target
DB01224QuetiapineMuscarinic acetylcholine receptor M4target
DB01224QuetiapineMuscarinic acetylcholine receptor M5target
DB01224Quetiapine5-hydroxytryptamine receptor 1Btarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Etarget
DB01224Quetiapine5-hydroxytryptamine receptor 3Atarget
DB01224Quetiapine5-hydroxytryptamine receptor 6target
DB01224Quetiapine5-hydroxytryptamine receptor 7target
DB01224QuetiapineDopamine D5 receptortarget
DB01224QuetiapineDopamine D1 receptortarget
DB01224QuetiapineDopamine D3 receptortarget
DB01224QuetiapineDopamine D4 receptortarget
DB01224QuetiapineCytochrome P450 3A5enzyme
DB01224QuetiapineP-glycoprotein 1transporter
DB01224QuetiapineCytochrome P450 2C19enzyme
DB01224QuetiapineCytochrome P450 2D6enzyme
DB01224QuetiapineCytochrome P450 3A7enzyme
DB00734RisperidoneHistamine H1 receptortarget
DB00734RisperidoneDopamine D2 receptortarget
DB00734RisperidoneAlpha-1A adrenergic receptortarget
DB00734Risperidone5-hydroxytryptamine receptor 2Atarget
DB00734RisperidoneAlpha-1B adrenergic receptortarget
DB00734RisperidoneCytochrome P450 2D6enzyme
DB00734RisperidoneDopamine D1 receptortarget
DB00734RisperidoneAlpha-2A adrenergic receptortarget
DB00734RisperidoneAlpha-2B adrenergic receptortarget
DB00734RisperidoneAlpha-2C adrenergic receptortarget
DB00734Risperidone5-hydroxytryptamine receptor 1Atarget
DB00734Risperidone5-hydroxytryptamine receptor 1Dtarget
DB00734Risperidone5-hydroxytryptamine receptor 2Ctarget
DB00734RisperidoneDopamine D3 receptortarget
DB00734RisperidoneDopamine D4 receptortarget
DB00734RisperidoneCytochrome P450 3A4enzyme
DB00734Risperidone5-hydroxytryptamine receptor 7target
DB00734RisperidoneP-glycoprotein 1transporter
DB06144Sertindole5-hydroxytryptamine receptor 2Atarget
DB06144Sertindole5-hydroxytryptamine receptor 2Ctarget
DB06144SertindoleDopamine D2 receptortarget
DB06144SertindoleAlpha-1A adrenergic receptortarget
DB06144SertindoleAlpha-1B adrenergic receptortarget
DB06144SertindoleAlpha-1D adrenergic receptortarget
DB06144SertindolePotassium voltage-gated channel subfamily H member 2target
DB06144Sertindole5-hydroxytryptamine receptor 6target
DB06144SertindoleCytochrome P450 2D6enzyme
DB06144SertindoleCytochrome P450 3A4enzyme
DB00246ZiprasidoneAlpha-1A adrenergic receptortarget
DB00246ZiprasidoneDopamine D2 receptortarget
DB00246Ziprasidone5-hydroxytryptamine receptor 2Ctarget
DB00246ZiprasidoneDopamine D3 receptortarget
DB00246Ziprasidone5-hydroxytryptamine receptor 1Atarget
DB00246Ziprasidone5-hydroxytryptamine receptor 1Dtarget
DB00246ZiprasidoneHistamine H1 receptortarget
DB00246Ziprasidone5-hydroxytryptamine receptor 2Atarget
DB00246ZiprasidoneDopamine D4 receptortarget
DB00246Ziprasidone5-hydroxytryptamine receptor 7target
DB00246ZiprasidoneCytochrome P450 3A4enzyme
DB00246ZiprasidoneAlpha-2A adrenergic receptortarget
DB00246ZiprasidoneAlpha-1B adrenergic receptortarget
DB00246ZiprasidoneAlpha-2B adrenergic receptortarget
DB00246ZiprasidoneAlpha-2C adrenergic receptortarget
DB00246ZiprasidoneDopamine D1 receptortarget
DB00246ZiprasidoneDopamine D5 receptortarget
DB00246ZiprasidoneMuscarinic acetylcholine receptor M1target
DB00246ZiprasidoneMuscarinic acetylcholine receptor M2target
DB00246ZiprasidoneMuscarinic acetylcholine receptor M3target
DB00246ZiprasidoneMuscarinic acetylcholine receptor M4target
DB00246ZiprasidoneMuscarinic acetylcholine receptor M5target
DB00246Ziprasidone5-hydroxytryptamine receptor 1Btarget
DB00246Ziprasidone5-hydroxytryptamine receptor 1Etarget
DB00246Ziprasidone5-hydroxytryptamine receptor 3Atarget
DB00246Ziprasidone5-hydroxytryptamine receptor 6target
DB00246ZiprasidoneAldehyde oxidaseenzyme
DB09225ZotepineD(1) dopamine receptortarget
DB09225ZotepineDopamine D2 receptortarget
DB09225Zotepine5-hydroxytryptamine receptor 2Atarget
DB09225Zotepine5-hydroxytryptamine receptor 6target
DB09225Zotepine5-hydroxytryptamine receptor 7target
DB09225ZotepineSodium-dependent noradrenaline transportertarget
DB09225ZotepineSodium-dependent serotonin transportertarget
DB09225ZotepineCytochrome P450 1A2enzyme
DB09225ZotepineCytochrome P450 3A4enzyme
DB06016CariprazineDopamine D3 receptortarget
DB06016CariprazineDopamine D2 receptortarget
DB06016CariprazineCytochrome P450 3A4enzyme
DB06016CariprazineCytochrome P450 2D6enzyme
DB06016Cariprazine5-hydroxytryptamine receptor 1Atarget
DB06016Cariprazine5-hydroxytryptamine receptor 2Btarget
DB06016Cariprazine5-hydroxytryptamine receptor 2Atarget
DB06016CariprazineHistamine H1 receptortarget
DB06077Lumateperone5-hydroxytryptamine receptor 2Atarget
DB06077LumateperoneDopamine D2 receptortarget
DB06077LumateperoneDopamine D1 receptortarget
DB06077LumateperoneSodium-dependent serotonin transportertarget
DB06077LumateperoneGlutamate receptor ionotropic, NMDA 2Btarget
DB06077LumateperoneAldo-keto reductase familyenzyme
DB06077LumateperoneCytochrome P450 3A4enzyme
DB06077LumateperoneCytochrome P450 2C8enzyme
DB06077LumateperoneCytochrome P450 1A2enzyme
DB06077LumateperoneUDP-glucuronosyltransferase 1-1enzyme
DB06077LumateperoneUDP-glucuronosyltransferase 1-4enzyme
DB06077LumateperoneUDP-glucuronosyltransferase 2B15enzyme
DB06077LumateperoneAldo-keto reductase family 1 member C1enzyme
DB06077LumateperoneAldo-keto reductase family 1 member B10enzyme
DB06077LumateperoneAldo-keto reductase family 1 member C4enzyme
DB05316Pimavanserin5-hydroxytryptamine receptor 2Atarget
DB05316PimavanserinDopamine D2 receptortarget
DB09128BrexpiprazoleCytochrome P450 2D6enzyme
DB09128BrexpiprazoleCytochrome P450 3A4enzyme
DB09128Brexpiprazole5-hydroxytryptamine receptor 1Atarget
DB09128BrexpiprazoleDopamine D2 receptortarget
DB09128Brexpiprazole5-hydroxytryptamine receptor 2Atarget
DB09128BrexpiprazoleAlpha-2C adrenergic receptortarget
DB09128BrexpiprazoleAlpha-1B adrenergic receptortarget
DB04888BifeprunoxDopamine D2 receptortarget
DB04888Bifeprunox5-hydroxytryptamine receptor 1Atarget