Amyloid Precursor Protein Secretases, antagonists & inhibitors

All categories
Name
Amyloid Precursor Protein Secretases, antagonists & inhibitors
Accession Number
DBCAT002788
Description

Not Available

Drugs
DrugDrug Description
RG-4733Ro4929097 has been used in trials studying the treatment of Sarcoma, LYMPHOMA, Neoplasms, Wilm's Tumor, and OSTEOSARCOMA, among others.
AvagacestatAvagacestat has been investigated for the basic science and treatment of Alzheimer Disease.
NirogacestatA gamma-secretase inhibitor used to treat desmoid tumors
SemagacestatSemagacestat has been used in trials studying the treatment of Alzheimer Disease.
MK-0752Mk 0752 is under investigation in clinical trial NCT00572182 (MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer).
ItanapracedNot Annotated
MRK-003MRK-003 is a potent and selective γ-secretase inhibitor developed by Merck. It is the preclinical analog of MK-0752, a drug in clinical development.
Drugs & Drug Targets
DrugTargetType
NirogacestatPresenilin-1target
NirogacestatCytochrome P450 3A4enzyme
NirogacestatCytochrome P450 2C9enzyme
NirogacestatCytochrome P450 2C19enzyme
NirogacestatCytochrome P450 2D6enzyme
NirogacestatCytochrome P450 2B6enzyme
NirogacestatSerum albumincarrier
Nirogacestatalpha1-acid glycoproteincarrier
NirogacestatP-glycoprotein 1transporter
NirogacestatCytochrome P450 2C8enzyme
MK-0752Gamma-secretase subunit APH-1Atarget