Increased Coagulation Activity

DrugDrug NameDrug Indication
DB11311ProthrombinFor use in the emergency reversal of coagulation factor deficiency in patients receiving vitamin K antagonist therapy. Prothrombin is administered as part of a cocktail containing several coagulation factors.
DB12909Factor XIII (human)Factor XIII (Human), available as the commercially available product Corifact, is approved by the Food and Drug Administration for routine prophylactic treatment and peri-operative management of surgical bleeding in adult and pediatric patients with congenital FXIII deficiency [FDA Label].
DB13152Coagulation Factor IX HumanFactor IX is used to treat Christmas disease. Factor IX deficiency is treated by injection factor IX produced from human plasma. Tranexamic acid may be of value in patients undergoing surgery who have inherited factor IX deficiency in order to reduce the perioperative risk of bleeding.
DB00100Coagulation Factor IX (Recombinant)For treatment of hemophilia (Christmas disease).
DB13150Coagulation factor VII humanMay be administered in cases of uncontrolled bleeding. Factor VII alone can be used in the treatment of congenital hemophilia A or B, acquired hemophilia, congenital factor VII deficiency, and Glanzmann's thrombasthenia. Off label use in the treatment of refractory bleeding after cardiac surgery and warfarin related intracerebral hemorrhage. Brands for human factor VII are currently only in combination with other vitamin K coagulation factors and can be used to reverse vitamin K antagonist activity in patients with acute major bleeds or for urgent surgery/invasive procedures.
DB13148Coagulation factor X humanIndicated in adults and children (aged 12 years and above) with hereditary Factor X deficiency for on-demand treatment and control of bleeding episodes, or for perioperative management of bleeding in patients with mild hereditary Factor X deficiency [FDA Label].
DB00025Antihemophilic factor, human recombinantFor the treatment of hemophilia A, von Willebrand disease and Factor XIII deficiency.
DB09222Fibrinogen HumanFor the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia.
DB13133Von Willebrand Factor HumanThe vWF and Factor VIII complex is indicated for the prevention of excessive bleeding during and after minor and major surgery in adult and pediatric von Willebrand disease patients. It is also indicated for the on-demand treatment and control of bleeding episodes.[L1880] The von Willebrand disease is an inherited disorder characterized by the deficiency or misfunction of the von Willebrand factor (vWF). Due to this deficiency, the blood cannot clot properly and the patients that present this disease are prone to prolonged or excessive bleeding. There are three types of this disease, and type 3 is an autosomal recessive inherited disorder marked by very low or absent levels of vWF.[L1867]
DB13192Antihemophilic factor humanThe human antihemophilic factor is indicated for the cases of hemophilia A, also known as classical hemophilia for the prevention and control of hemorrhagic episodes.[L1055] If surgery is needed in patients with hemophilia A there is a need of correction of the clotting abnormality. In this cases, the human antihemophilic factor may be administered followed by intermittent maintenance doses.[L1053] The hemophilia A is characterized by the deficiency of the coagulation factor VIII that results in prolonged blood flow after injury or surgery as well as recurrent bleeding.[T56]
DrugDrug NameTargetType
DB11311ProthrombinFibrinogen alpha chaintarget
DB11311ProthrombinFibrinogen beta chaintarget
DB11311ProthrombinCoagulation factor XIII A chaintarget
DB11311ProthrombinCarboxypeptidase B2target
DB11311ProthrombinCoagulation factor Xenzyme
DB13152Coagulation Factor IX HumanCoagulation factor Xtarget
DB13152Coagulation Factor IX HumanCoagulation factor XItarget
DB13152Coagulation Factor IX HumanCoagulation factor VIItarget
DB13152Coagulation Factor IX HumanCoagulation factor VIIItarget
DB13152Coagulation Factor IX HumanProthrombintarget
DB13152Coagulation Factor IX HumanProlow-density lipoprotein receptor-related protein 1target
DB13152Coagulation Factor IX HumanVitamin K-dependent gamma-carboxylasetarget
DB00100Coagulation Factor IX (Recombinant)Coagulation factor Xtarget
DB00100Coagulation Factor IX (Recombinant)Coagulation factor XItarget
DB00100Coagulation Factor IX (Recombinant)Coagulation factor VIIItarget
DB00100Coagulation Factor IX (Recombinant)Prothrombintarget
DB00100Coagulation Factor IX (Recombinant)Coagulation factor VIItarget
DB00100Coagulation Factor IX (Recombinant)Vitamin K-dependent gamma-carboxylasetarget
DB00100Coagulation Factor IX (Recombinant)Prolow-density lipoprotein receptor-related protein 1target
DB13150Coagulation factor VII humanTissue factortarget
DB13150Coagulation factor VII humanCoagulation factor Xtarget
DB13150Coagulation factor VII humanCoagulation factor IXtarget
DB00025Antihemophilic factor, human recombinantCoagulation factor Xtarget
DB00025Antihemophilic factor, human recombinantPhytanoyl-CoA dioxygenase, peroxisomaltarget
DB00025Antihemophilic factor, human recombinantCoagulation factor IXtarget
DB00025Antihemophilic factor, human recombinantAsialoglycoprotein receptor 2target
DB00025Antihemophilic factor, human recombinant78 kDa glucose-regulated proteintarget
DB00025Antihemophilic factor, human recombinantCalreticulintarget
DB00025Antihemophilic factor, human recombinantCalnexintarget
DB00025Antihemophilic factor, human recombinantProtein ERGIC-53target
DB00025Antihemophilic factor, human recombinantProlow-density lipoprotein receptor-related protein 1target
DB00025Antihemophilic factor, human recombinantMultiple coagulation factor deficiency protein 2target
DB00025Antihemophilic factor, human recombinantvon Willebrand factortarget
DB00025Antihemophilic factor, human recombinantProthrombinenzyme
DB00025Antihemophilic factor, human recombinantVitamin K-dependent protein Cenzyme
DB13133Von Willebrand Factor HumanCoagulation factor VIIItarget
DB13133Von Willebrand Factor HumanCollagen alpha-1(I) chaintarget
DB13133Von Willebrand Factor HumanA disintegrin and metalloproteinase with thrombospondin motifs 13enzyme
DB13192Antihemophilic factor humanCoagulation factor IXtarget
DB13192Antihemophilic factor humanCoagulation factor Xtarget
DB13192Antihemophilic factor humanVitamin K-dependent protein Cenzyme