Aromatic L-amino Acid Decarboxylase Inhibitors
- Name
- Aromatic L-amino Acid Decarboxylase Inhibitors
- Accession Number
- DBCAT005152
- Description
Aromatic L-amino acid decarboxylase is the enzyme responsible for the conversion of L-DOPA to dopamine. Inhibitors of this enzyme are typically unable to cross the blood-brain-barrier, meaning they remain in the periphery and inhibit peripheral dopamine synthesis. The end result is more L-DOPA available for central conversion into dopamine, in essence increasing the oral bioavailability of L-DOPA.
- Drugs
Drug Drug Description Benserazide A medication used to treat Parkinson's disease, parkinsonism, and restless leg syndrome. Carbidopa A dopa decarboxylase inhibitor used in combination with levodopa for the symptomatic treatment of idiopathic Parkinson disease and other conditions associated with parkinsonian symptoms. Methyldopa A centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises. - Drugs & Drug Targets