Human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitors

All categories
Name
Human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitors
Accession Number
DBCAT005736
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
LapatinibAn antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-positive breast cancer in patients who received prior chemotherapeutic treatments.
TucatinibA kinase inhibitor used to treat certain types of unresectable/metastatic HER-2 positive breast cancer.
NeratinibA protein kinase inhibitor used to treat breast cancer that over expresses the HER2 receptor.
Drugs & Drug Targets
DrugTargetType
LapatinibEpidermal growth factor receptortarget
LapatinibReceptor tyrosine-protein kinase erbB-2target
LapatinibCytochrome P450 3A4enzyme
LapatinibCytochrome P450 2C8enzyme
LapatinibP-glycoprotein 1transporter
LapatinibAntigen peptide transporter 1transporter
LapatinibCytochrome P450 3A5enzyme
LapatinibCytochrome P450 2C19enzyme
TucatinibReceptor tyrosine-protein kinase erbB-2target
TucatinibATP-binding cassette sub-family G member 2transporter
TucatinibP-glycoprotein 1transporter
TucatinibSolute carrier family 22 member 2transporter
TucatinibMultidrug and toxin extrusion protein 1transporter
TucatinibMultidrug and toxin extrusion protein 2transporter
TucatinibCytochrome P450 2C8enzyme
TucatinibCytochrome P450 3A Subfamilyenzyme
TucatinibReceptor tyrosine-protein kinase erbB-2enzyme
TucatinibReceptor tyrosine-protein kinase erbB-3target
NeratinibCytochrome P450 3A4enzyme
NeratinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
NeratinibP-glycoprotein 1transporter
NeratinibEpidermal growth factor receptortarget
NeratinibSerum albumincarrier
Neratinibalpha1-acid glycoproteincarrier