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Identification
NameBeta-D-Glucose
Accession NumberDB02379  (EXPT00685, EXPT00455, EXPT01603)
TypeSmall Molecule
GroupsExperimental
DescriptionA primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. [PubChem]
Structure
Thumb
Synonyms
beta-D-glucopyranose
Beta-D-glucose anhydrous
Beta-D-glucose, anhydrous
Glucose, beta-D
Glucose, beta-D-
Glucoside
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
CategoriesNot Available
UNIIJ4R00M814D
CAS number492-61-5
WeightAverage: 180.1559
Monoisotopic: 180.063388116
Chemical FormulaC6H12O6
InChI KeyWQZGKKKJIJFFOK-VFUOTHLCSA-N
InChI
InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
IUPAC Name
(2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
SMILES
OC[[email protected]]1O[C@@H](O)[[email protected]](O)[C@@H](O)[C@@H]1O
Pharmacology
IndicationNot Available
Structured Indications Not Available
PharmacodynamicsNot Available
Mechanism of action
TargetKindPharmacological actionActionsOrganismUniProt ID
DNANucleotideunknownNot AvailableHumannot applicabledetails
Chondroitinase-BProteinunknownNot AvailablePedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)Q46079 details
Endoglucanase 5AProteinunknownNot AvailableBacillus agaradhaerensO85465 details
Lactase-like proteinProteinunknownNot AvailableHumanQ6UWM7 details
Glycogen phosphorylase, muscle formProteinunknownNot AvailableHumanP11217 details
Xylose isomeraseProteinunknownNot AvailableStreptomyces olivochromogenesP15587 details
GlucokinaseProteinunknownNot AvailableHumanP35557 details
Ferrichrome-iron receptorProteinunknownNot AvailableEscherichia coli (strain K12)P06971 details
Neopullulanase 1ProteinunknownNot AvailableThermoactinomyces vulgarisQ60053 details
Cyclomaltodextrin glucanotransferaseProteinunknownNot AvailableBacillus circulansP30920 details
MyoglobinProteinunknownNot AvailableHumanP02144 details
Prostaglandin G/H synthase 1ProteinunknownNot AvailableHumanP23219 details
Hexokinase-1ProteinunknownNot AvailableHumanP19367 details
Alpha-amylaseProteinunknownNot AvailableBacillus subtilis (strain 168)P00691 details
Exoglucanase/xylanaseProteinunknownNot AvailableCellulomonas fimiP07986 details
Cyclomaltodextrin glucanotransferaseProteinunknownNot AvailableBacillus sp. (strain 1011)P05618 details
Endoglucanase GProteinunknownNot AvailableClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)P37700 details
Galectin-7ProteinunknownNot AvailableHumanP47929 details
Cholera enterotoxin subunit BProteinunknownNot AvailableVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)P01556 details
Dimethyl sulfoxide/trimethylamine N-oxide reductaseProteinunknownNot AvailableRhodobacter sphaeroidesQ57366 details
Alpha-amylase 2BProteinunknownNot AvailableHumanP19961 details
Neopullulanase 2ProteinunknownNot AvailableThermoactinomyces vulgarisQ08751 details
Botulinum neurotoxin type BProteinunknownNot AvailableClostridium botulinumP10844 details
Tetanus toxinProteinunknownNot AvailableClostridium tetani (strain Massachusetts / E88)P04958 details
Xylose isomeraseProteinunknownNot AvailableStreptomyces rubiginosusP24300 details
Glucan 1,4-alpha-maltohexaosidaseProteinunknownNot AvailableBacillus sp. (strain 707)P19571 details
Glucan 1,4-alpha-maltotetraohydrolaseProteinunknownNot AvailablePseudomonas stutzeriP13507 details
Endoglucanase FProteinunknownNot AvailableClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)P37698 details
Glucose--fructose oxidoreductaseProteinunknownNot AvailableZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)Q07982 details
Tail fiber proteinProteinunknownNot AvailableEnterobacteria phage P22P12528 details
Glycogen phosphorylase, liver formProteinunknownNot AvailableHumanP06737 details
Pulmonary surfactant-associated protein DProteinunknownNot AvailableHumanP35247 details
Interferon betaProteinunknownNot AvailableHumanP01574 details
Alpha-amylaseProteinunknownNot AvailablePseudoalteromonas haloplanktisP29957 details
Glycosyltransferase 6 domain-containing protein 1ProteinunknownNot AvailableHumanQ7Z4J2 details
Glucosamine-6-phosphate isomerase 1ProteinunknownNot AvailableHumanP46926 details
Beta-amylaseProteinunknownNot AvailableBacillus cereusP36924 details
ADP-ribose pyrophosphatase, mitochondrialProteinunknownNot AvailableHumanQ9BW91 details
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5ProteinunknownNot AvailableHumanO60264 details
Cyclomaltodextrin glucanotransferaseProteinunknownNot AvailableThermoanaerobacter thermosulfurogenesP26827 details
Enterotoxin type BProteinunknownNot AvailableStaphylococcus aureusP01552 details
Alpha-amylase 1ProteinunknownNot AvailableHumanP04745 details
Maltodextrin phosphorylaseProteinunknownNot AvailableEscherichia coli (strain K12)P00490 details
Shiga-like toxin 1 subunit BProteinunknownNot AvailableBacteriophage H30P69178 details
Neurocan core proteinProteinunknownNot AvailableHumanO14594 details
Beta-glucanaseProteinunknownNot AvailablePaenibacillus maceransP23904 details
Quinoprotein glucose dehydrogenase BProteinunknownNot AvailableAcinetobacter calcoaceticusP13650 details
Alpha-amylaseProteinunknownNot AvailableBacillus amyloliquefaciensP00692 details
Maltose-binding periplasmic proteinProteinunknownNot AvailableEscherichia coli (strain K12)P0AEX9 details
Enoyl-[acyl-carrier-protein] reductase [NADH] FabIProteinunknownNot AvailableEscherichia coli (strain K12)P0AEK4 details
Endoglucanase AProteinunknownNot AvailableClostridium thermocellumP0C2S2 details
Cellulose 1,4-beta-cellobiosidase (reducing end) CelSProteinunknownNot AvailableClostridium thermocellumP0C2S5 details
D-galactose-binding periplasmic proteinProteinunknownNot AvailableEscherichia coli (strain K12)P0AEE5 details
Cellulase BProteinunknownNot AvailableStreptomyces lividansQ54331 details
Aspartate ammonia-lyaseProteinunknownNot AvailableEscherichia coli (strain K12)P0AC38 details
Possible cellulase CelA1 (Endoglucanase) (Endo-1,4-beta-glucanase) (FI-cmcase) (Carboxymethyl cellulase)ProteinunknownNot AvailableMycobacterium tuberculosisQ79G13 details
GlucokinaseProteinunknownNot AvailableEscherichia coli (strain K12)P0A6V8 details
AmylaseProteinunknownNot AvailableBacillus sp.O82839 details
Fucose-binding lectin PA-IILProteinunknownNot AvailablePseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Q9HYN5 details
BH0236 proteinProteinunknownNot AvailableBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)Q9KG76 details
LaminarinaseProteinunknownNot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Q9WXN1 details
Endo-1,4-beta-xylanase AProteinunknownNot AvailableClostridium stercorariumQ8GJ44 details
Cellulase BProteinunknownNot AvailableCellvibrio mixtusO07653 details
Endoglucanase CProteinunknownNot AvailableCellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547)P14090 details
Aldose 1-epimeraseProteinunknownNot AvailableLactococcus lactisQ9ZB17 details
AmylosucraseProteinunknownNot AvailableNeisseria polysacchareaQ9ZEU2 details
Pancreatic alpha-amylaseProteinunknownNot AvailableHumanP04746 details
Putative monooxygenase MoxCProteinunknownNot AvailableBacillus subtilis (strain 168)O34974 details
Endoglucanase E1ProteinunknownNot AvailableAcidothermus cellulolyticus (strain ATCC 43068 / 11B)P54583 details
D-galactose-binding periplasmic proteinProteinunknownNot AvailableSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)P23905 details
EcotinProteinunknownNot AvailableEscherichia coli (strain K12)P23827 details
Adenine DNA glycosylaseProteinunknownNot AvailableEscherichia coli (strain K12)P17802 details
Keratin-associated protein 5-2ProteinunknownNot AvailableHumanQ701N4 details
SialoadhesinProteinunknownNot AvailableHumanQ9BZZ2 details
NeopullulanaseProteinunknownNot AvailableGeobacillus stearothermophilusP38940 details
Endo-1,4-beta-xylanase AProteinunknownNot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Q60037 details
MaltoporinProteinunknownNot AvailableSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)P26466 details
HexokinaseProteinunknownNot AvailableBlood flukeQ26609 details
Endo-1,4-beta-xylanaseProteinunknownNot AvailableGeobacillus stearothermophilusP40943 details
MaltoporinProteinunknownNot AvailableEscherichia coli (strain K12)P02943 details
Galectin-2ProteinunknownNot AvailableHumanP05162 details
Malto-oligosyltrehalose trehalohydrolaseProteinunknownNot AvailableDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Q9RX51 details
Inorganic polyphosphate/ATP-glucomannokinaseProteinunknownNot AvailableArthrobacter sp. (strain KM)Q7WT42 details
Diacetyl reductase [(S)-acetoin forming]ProteinunknownNot AvailableKlebsiella pneumoniaeQ48436 details
Capsid protein VP1ProteinunknownNot AvailableMPyVP49302 details
Beta-xylanaseProteinunknownNot AvailableStreptomyces olivaceoviridisQ7SI98 details
Keratin-associated protein 5-3ProteinunknownNot AvailableHumanQ6L8H2 details
Endoglucanase C307ProteinunknownNot AvailableClostridium sp. (strain F1)P23340 details
Endo-1,4-beta glucanase EngFProteinunknownNot AvailableClostridium cellulovoransP94622 details
Endoglucanase E-4ProteinunknownNot AvailableThermomonospora fuscaP26221 details
Orf proteinProteinunknownNot AvailableEscherichia coliQ47644 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug InteractionsNot Available
Food InteractionsNot Available
References
Synthesis Reference

Chen Gong, “Method for preparation of 2’-deoxy-2’, 2’-difluoro-beta-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-beta-D-glucose as raw material.” U.S. Patent US20060003963, issued January 05, 2006.

US20060003963
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET featuresNot Available
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point83 °CPhysProp
water solubility1.2E+006 mg/L (at 30 °C)MULLIN,JW (1972)
logP-3.24SANGSTER (1994)
logS0.74ADME Research, USCD
pKa12.9 (at 0 °C)KORTUM,G ET AL (1961)
Predicted Properties
PropertyValueSource
Water Solubility782.0 mg/mLALOGPS
logP-2.6ALOGPS
logP-2.9ChemAxon
logS0.64ALOGPS
pKa (Strongest Acidic)11.3ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area110.38 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity35.92 m3·mol-1ChemAxon
Polarizability16.43 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MSNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-01q9-0900000000-ecd0aedc67c9a2eec60fView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-03ea-2900000000-e4daf22c7320ccc41812View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0005-9200000000-91fc3940732f782a88bbView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-004i-1900000000-e9f3e728d1b340759a09View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-01t9-5900000000-c0a478f2b9c5bbc6c4baView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0006-9100000000-06852e2088bf1c6b38c4View in MoNA
MSMass Spectrum (Electron Ionization)splash10-03kc-9000000000-a60df7b043f8947d6909View in MoNA
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as monosaccharides. These are compounds containing one carbohydrate unit not glycosidically linked to another such unit, and no set of two or more glycosidically linked carbohydrate units. Monosaccharides have the general formula CnH2nOn.
KingdomOrganic compounds
Super ClassOrganooxygen compounds
ClassCarbohydrates and carbohydrate conjugates
Sub ClassMonosaccharides
Direct ParentMonosaccharides
Alternative Parents
Substituents
  • Oxane
  • Monosaccharide
  • Secondary alcohol
  • Polyol
  • Hemiacetal
  • 1,2-diol
  • Oxacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Primary alcohol
  • Alcohol
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors

Targets

1. DNA
Kind
Nucleotide
Organism
Human
Pharmacological action
unknown
General Function:
Used for biological information storage.
Specific Function:
DNA contains the instructions needed for an organism to develop, survive and reproduce.
Molecular Weight:
2.15 x 1012 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)
Pharmacological action
unknown
General Function:
Chondroitin b lyase activity
Specific Function:
Cleaves the glycosaminoglycan, dermatan sulfate.
Gene Name:
cslB
Uniprot ID:
Q46079
Molecular Weight:
56336.075 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Bacillus agaradhaerens
Pharmacological action
unknown
General Function:
Cellulase activity
Specific Function:
Not Available
Gene Name:
cel5A
Uniprot ID:
O85465
Molecular Weight:
44701.845 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Hydrolase activity, hydrolyzing o-glycosyl compounds
Specific Function:
Not Available
Gene Name:
LCTL
Uniprot ID:
Q6UWM7
Molecular Weight:
65087.84 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Pyridoxal phosphate binding
Specific Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Gene Name:
PYGM
Uniprot ID:
P11217
Molecular Weight:
97091.265 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Streptomyces olivochromogenes
Pharmacological action
unknown
General Function:
Xylose isomerase activity
Specific Function:
Involved in D-xylose catabolism.
Gene Name:
xylA
Uniprot ID:
P15587
Molecular Weight:
42922.7 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Glucose binding
Specific Function:
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate...
Gene Name:
GCK
Uniprot ID:
P35557
Molecular Weight:
52191.07 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Virion binding
Specific Function:
This receptor binds the ferrichrome-iron ligand. It interacts with the TonB protein, which is responsible for energy coupling of the ferrichrome-promoted iron transport system. Acts as a receptor for bacteriophage T5 as well as T1, phi80 and colicin M. Binding of T5 triggers the opening of a high conductance ion channel. Can also transport the antibiotic albomycin.
Gene Name:
fhuA
Uniprot ID:
P06971
Molecular Weight:
82181.75 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Thermoactinomyces vulgaris
Pharmacological action
unknown
General Function:
Neopullulanase activity
Specific Function:
Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Also hydrolyzes cyclodextrins.
Gene Name:
tvaI
Uniprot ID:
Q60053
Molecular Weight:
74295.435 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Bacillus circulans
Pharmacological action
unknown
General Function:
Starch binding
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P30920
Molecular Weight:
78046.265 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Oxygen transporter activity
Specific Function:
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
Gene Name:
MB
Uniprot ID:
P02144
Molecular Weight:
17183.725 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Mannokinase activity
Specific Function:
Not Available
Gene Name:
HK1
Uniprot ID:
P19367
Molecular Weight:
102485.1 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Not Available
Gene Name:
amyE
Uniprot ID:
P00691
Molecular Weight:
72377.4 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Cellulomonas fimi
Pharmacological action
unknown
General Function:
Polysaccharide binding
Specific Function:
Hydrolyzes both cellulose and xylan. Has also weak endoglucanase activity.The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which ...
Gene Name:
cex
Uniprot ID:
P07986
Molecular Weight:
51290.845 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Bacillus sp. (strain 1011)
Pharmacological action
unknown
General Function:
Starch binding
Specific Function:
Not Available
Gene Name:
cgt
Uniprot ID:
P05618
Molecular Weight:
78340.03 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Pharmacological action
unknown
General Function:
Cellulose binding
Specific Function:
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
Gene Name:
celCCG
Uniprot ID:
P37700
Molecular Weight:
79775.34 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Carbohydrate binding
Specific Function:
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
Gene Name:
LGALS7
Uniprot ID:
P47929
Molecular Weight:
15074.965 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Pharmacological action
unknown
General Function:
Host cell surface binding
Specific Function:
The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
Gene Name:
ctxB
Uniprot ID:
P01556
Molecular Weight:
13957.055 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Rhodobacter sphaeroides
Pharmacological action
unknown
General Function:
Trimethylamine-n-oxide reductase (cytochrome c) activity
Specific Function:
Catalyzes the reduction of dimethyl sulfoxide (DMSO) and trimethylamine N-oxide (TMAO) to dimethyl sulfide (DMS) and trimethylamine, respectively. The terminal DMSO reductase can also use various sulfoxides and N-oxide compounds as terminal electron acceptor in addition to DMSO and TMAO.
Gene Name:
dmsA
Uniprot ID:
Q57366
Molecular Weight:
89206.805 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Not Available
Gene Name:
AMY2B
Uniprot ID:
P19961
Molecular Weight:
57709.49 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Thermoactinomyces vulgaris
Pharmacological action
unknown
General Function:
Neopullulanase activity
Specific Function:
Hydrolyzes pullulan efficiently but only a small amount of starch. Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Cleaves also (1-6)-alpha-glucosidic linkages to form maltotriose.
Gene Name:
tvaII
Uniprot ID:
Q08751
Molecular Weight:
67466.71 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Clostridium botulinum
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
Gene Name:
botB
Uniprot ID:
P10844
Molecular Weight:
150801.16 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Clostridium tetani (strain Massachusetts / E88)
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
Gene Name:
tetX
Uniprot ID:
P04958
Molecular Weight:
150680.98 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Streptomyces rubiginosus
Pharmacological action
unknown
General Function:
Xylose isomerase activity
Specific Function:
Involved in D-xylose catabolism.
Gene Name:
xylA
Uniprot ID:
P24300
Molecular Weight:
43226.915 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Bacillus sp. (strain 707)
Pharmacological action
unknown
General Function:
Glucan 1,4-alpha-maltohexaosidase activity
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P19571
Molecular Weight:
59008.445 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Pseudomonas stutzeri
Pharmacological action
unknown
General Function:
Starch binding
Specific Function:
Not Available
Gene Name:
amyP
Uniprot ID:
P13507
Molecular Weight:
59875.725 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Pharmacological action
unknown
General Function:
Cellulase activity
Specific Function:
Probable endoglucanase involved in the degradation of cellulose or related beta-glucans.
Gene Name:
celCCF
Uniprot ID:
P37698
Molecular Weight:
80543.885 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Pharmacological action
unknown
General Function:
Glucose-fructose oxidoreductase activity
Specific Function:
Not Available
Gene Name:
gfo
Uniprot ID:
Q07982
Molecular Weight:
47189.15 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Enterobacteria phage P22
Pharmacological action
unknown
General Function:
Hydrolase activity, acting on glycosyl bonds
Specific Function:
Structural component of the short non-contractile tail. The tail comprises six fibers that mediate primary attachment to the host cell lipopolysaccharides (LPS) and display endorhamnosidase enzymatic activity, hydrolyzing the alpha-1,3-O-glycosidic linkage between rhamnose and galactose of the O-antigen polysaccharide. Digestion of the LPS brings the capsid near the cell outer membrane.
Gene Name:
9
Uniprot ID:
P12528
Molecular Weight:
71856.28 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Vitamin binding
Specific Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Gene Name:
PYGL
Uniprot ID:
P06737
Molecular Weight:
97147.82 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Carbohydrate binding
Specific Function:
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alph...
Gene Name:
SFTPD
Uniprot ID:
P35247
Molecular Weight:
37728.19 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Type i interferon receptor binding
Specific Function:
Has antiviral, antibacterial and anticancer activities.
Gene Name:
IFNB1
Uniprot ID:
P01574
Molecular Weight:
22293.68 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Pseudoalteromonas haloplanktis
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Not Available
Gene Name:
amy
Uniprot ID:
P29957
Molecular Weight:
73267.4 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Transferase activity, transferring hexosyl groups
Specific Function:
Not Available
Gene Name:
GLT6D1
Uniprot ID:
Q7Z4J2
Molecular Weight:
36273.575 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Hydrolase activity
Specific Function:
Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).
Gene Name:
GNPDA1
Uniprot ID:
P46926
Molecular Weight:
32668.29 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Bacillus cereus
Pharmacological action
unknown
General Function:
Starch binding
Specific Function:
Not Available
Gene Name:
spoII
Uniprot ID:
P36924
Molecular Weight:
61628.585 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Adp-sugar diphosphatase activity
Specific Function:
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
Gene Name:
NUDT9
Uniprot ID:
Q9BW91
Molecular Weight:
39124.685 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Helicase activity
Specific Function:
Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of ...
Gene Name:
SMARCA5
Uniprot ID:
O60264
Molecular Weight:
121904.335 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Thermoanaerobacter thermosulfurogenes
Pharmacological action
unknown
General Function:
Starch binding
Specific Function:
Degrades starch to alpha-, beta-, and gamma-cyclodextrins, as well as linear sugars.
Gene Name:
amyA
Uniprot ID:
P26827
Molecular Weight:
78416.955 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Staphylococcus aureus
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
Gene Name:
entB
Uniprot ID:
P01552
Molecular Weight:
31435.675 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Not Available
Gene Name:
AMY1A
Uniprot ID:
P04745
Molecular Weight:
57767.49 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Pyridoxal phosphate binding
Specific Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Gene Name:
malP
Uniprot ID:
P00490
Molecular Weight:
90521.74 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Bacteriophage H30
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.
Gene Name:
stxB
Uniprot ID:
P69178
Molecular Weight:
9743.07 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Hyaluronic acid binding
Specific Function:
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
Gene Name:
NCAN
Uniprot ID:
O14594
Molecular Weight:
143092.14 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Paenibacillus macerans
Pharmacological action
unknown
General Function:
Licheninase activity
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P23904
Molecular Weight:
26588.59 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Acinetobacter calcoaceticus
Pharmacological action
unknown
General Function:
Quinoprotein glucose dehydrogenase activity
Specific Function:
Oxidizes glucose to gluconolactone.
Gene Name:
gdhB
Uniprot ID:
P13650
Molecular Weight:
52772.255 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Bacillus amyloliquefaciens
Pharmacological action
unknown
General Function:
Calcium ion binding
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P00692
Molecular Weight:
58402.605 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Transporter activity
Specific Function:
Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
Gene Name:
malE
Uniprot ID:
P0AEX9
Molecular Weight:
43387.235 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Identical protein binding
Specific Function:
Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.
Gene Name:
fabI
Uniprot ID:
P0AEK4
Molecular Weight:
27863.645 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Clostridium thermocellum
Pharmacological action
unknown
General Function:
Cellulase activity
Specific Function:
This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
Gene Name:
celA
Uniprot ID:
P0C2S2
Molecular Weight:
1449.625 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Clostridium thermocellum
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
This enzyme catalyzes the exohydrolysis of 1,4-beta-glucosidic linkages in cellulose with a preference for amorphous or crystalline cellulose over carboxymethyl cellulose.
Gene Name:
celS
Uniprot ID:
P0C2S5
Molecular Weight:
83557.84 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor.
Gene Name:
mglB
Uniprot ID:
P0AEE5
Molecular Weight:
35712.285 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Streptomyces lividans
Pharmacological action
unknown
General Function:
Polysaccharide binding
Specific Function:
Not Available
Gene Name:
celB
Uniprot ID:
Q54331
Molecular Weight:
39239.03 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Aspartate ammonia-lyase activity
Specific Function:
Not Available
Gene Name:
aspA
Uniprot ID:
P0AC38
Molecular Weight:
52355.755 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
unknown
General Function:
Cellulase activity
Specific Function:
Not Available
Gene Name:
celA1
Uniprot ID:
Q79G13
Molecular Weight:
39973.515 Da
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Glucokinase activity
Specific Function:
Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate.
Gene Name:
glk
Uniprot ID:
P0A6V8
Molecular Weight:
34722.76 Da
Kind
Protein
Organism
Bacillus sp.
Pharmacological action
unknown
General Function:
Hydrolase activity, hydrolyzing o-glycosyl compounds
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
O82839
Molecular Weight:
58841.335 Da
Kind
Protein
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Not Available
Gene Name:
lecB
Uniprot ID:
Q9HYN5
Molecular Weight:
11862.99 Da
Kind
Protein
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Pharmacological action
unknown
General Function:
Glucan endo-1,4-beta-glucanase activity, c-3 substituted reducing group
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q9KG76
Molecular Weight:
114875.925 Da
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q9WXN1
Molecular Weight:
72539.765 Da
Kind
Protein
Organism
Clostridium stercorarium
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Endoxylanase that degrades arabinoxylan and glucuronoxylan to xylobiose and xylotriose (in vitro).
Gene Name:
xynA
Uniprot ID:
Q8GJ44
Molecular Weight:
70150.25 Da
Kind
Protein
Organism
Cellvibrio mixtus
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Not Available
Gene Name:
celB
Uniprot ID:
O07653
Molecular Weight:
65888.415 Da
Kind
Protein
Organism
Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547)
Pharmacological action
unknown
General Function:
Cellulase activity
Specific Function:
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
Gene Name:
cenC
Uniprot ID:
P14090
Molecular Weight:
115215.07 Da
Kind
Protein
Organism
Lactococcus lactis
Pharmacological action
unknown
General Function:
Carbohydrate binding
Specific Function:
Converts alpha-aldose to the beta-anomer.
Gene Name:
galM
Uniprot ID:
Q9ZB17
Molecular Weight:
37610.85 Da
Kind
Protein
Organism
Neisseria polysaccharea
Pharmacological action
unknown
General Function:
Cation binding
Specific Function:
Catalyzes the synthesis of alpha-glucan from sucrose. Catalyzes, in addition, sucrose hydrolysis, maltose and maltotriose synthesis by successive transfers of the glucosyl moiety of sucrose onto the released glucose, and finally turanose and trehalulose synthesis, these two sucrose isomers being obtained by glucosyl transfer onto fructose.
Gene Name:
ams
Uniprot ID:
Q9ZEU2
Molecular Weight:
72343.005 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Chloride ion binding
Specific Function:
Not Available
Gene Name:
AMY2A
Uniprot ID:
P04746
Molecular Weight:
57706.51 Da
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
unknown
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Specific Function:
May play a role in methionine degradation. May play a role in a sulfur salvage pathway.
Gene Name:
moxC
Uniprot ID:
O34974
Molecular Weight:
49410.955 Da
Kind
Protein
Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Pharmacological action
unknown
General Function:
Polysaccharide binding
Specific Function:
Has a very high specific activity on carboxymethylcellulose.
Gene Name:
Not Available
Uniprot ID:
P54583
Molecular Weight:
60747.355 Da
Kind
Protein
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor.
Gene Name:
mglB
Uniprot ID:
P23905
Molecular Weight:
35813.375 Da
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Serine-type endopeptidase inhibitor activity
Specific Function:
General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity.
Gene Name:
eco
Uniprot ID:
P23827
Molecular Weight:
18191.925 Da
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
Gene Name:
mutY
Uniprot ID:
P17802
Molecular Weight:
39148.835 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyro...
Gene Name:
KRTAP5-2
Uniprot ID:
Q701N4
Molecular Weight:
16270.68 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Carbohydrate binding
Specific Function:
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoie...
Gene Name:
SIGLEC1
Uniprot ID:
Q9BZZ2
Molecular Weight:
182622.32 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Geobacillus stearothermophilus
Pharmacological action
unknown
General Function:
Neopullulanase activity
Specific Function:
Hydrolyzes pullulan efficiently but only a small amount of starch. Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Cleaves also (1-6)-alpha-glucosidic linkages to form maltotriose.
Gene Name:
nplT
Uniprot ID:
P38940
Molecular Weight:
69144.625 Da
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
unknown
General Function:
Endo-1,4-beta-xylanase activity
Specific Function:
Not Available
Gene Name:
xynA
Uniprot ID:
Q60037
Molecular Weight:
119642.43 Da
Kind
Protein
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Pharmacological action
unknown
General Function:
Maltose transporting porin activity
Specific Function:
Involved in the transport of maltose and maltodextrins. Does not act as a receptor for phages.
Gene Name:
lamB
Uniprot ID:
P26466
Molecular Weight:
50548.715 Da
Kind
Protein
Organism
Blood fluke
Pharmacological action
unknown
General Function:
Hexokinase activity
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q26609
Molecular Weight:
50445.62 Da
Kind
Protein
Organism
Geobacillus stearothermophilus
Pharmacological action
unknown
General Function:
Endo-1,4-beta-xylanase activity
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P40943
Molecular Weight:
46763.15 Da
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Virus receptor activity
Specific Function:
Involved in the transport of maltose and maltodextrins, indispensable for translocation of dextrins containing more than three glucosyl moieties. A hydrophobic path ("greasy slide") of aromatic residues serves to guide and select the sugars for transport through the channel. Also acts as a receptor for several bacteriophages including lambda.
Gene Name:
lamB
Uniprot ID:
P02943
Molecular Weight:
49912.005 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Galactoside binding
Specific Function:
This protein binds beta-galactoside. Its physiological function is not yet known.
Gene Name:
LGALS2
Uniprot ID:
P05162
Molecular Weight:
14644.375 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Pharmacological action
unknown
General Function:
Cation binding
Specific Function:
Not Available
Gene Name:
treZ
Uniprot ID:
Q9RX51
Molecular Weight:
66909.235 Da
Kind
Protein
Organism
Arthrobacter sp. (strain KM)
Pharmacological action
unknown
General Function:
Kinase activity
Specific Function:
Not Available
Gene Name:
ppgmk
Uniprot ID:
Q7WT42
Molecular Weight:
27995.82 Da
Kind
Protein
Organism
Klebsiella pneumoniae
Pharmacological action
unknown
General Function:
Diacetyl reductase ((s)-acetoin forming) activity
Specific Function:
Catalyzes the reversible reduction of (S)-acetoin to 2,3-butanediol in the presence of NADH.
Gene Name:
budC
Uniprot ID:
Q48436
Molecular Weight:
26642.245 Da
Kind
Protein
Organism
MPyV
Pharmacological action
unknown
General Function:
Structural molecule activity
Specific Function:
Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with terminal alpha(2,3)-linked sialic acids on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through caveolin-mediated ...
Gene Name:
Not Available
Uniprot ID:
P49302
Molecular Weight:
42505.275 Da
Kind
Protein
Organism
Streptomyces olivaceoviridis
Pharmacological action
unknown
General Function:
Endo-1,4-beta-xylanase activity
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q7SI98
Molecular Weight:
46749.175 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyro...
Gene Name:
KRTAP5-3
Uniprot ID:
Q6L8H2
Molecular Weight:
22105.295 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Clostridium sp. (strain F1)
Pharmacological action
unknown
General Function:
Cellulase activity
Specific Function:
This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
Gene Name:
celC307
Uniprot ID:
P23340
Molecular Weight:
40905.03 Da
Kind
Protein
Organism
Clostridium cellulovorans
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Not Available
Gene Name:
engF
Uniprot ID:
P94622
Molecular Weight:
60130.5 Da
Kind
Protein
Organism
Thermomonospora fusca
Pharmacological action
unknown
General Function:
Cellulose binding
Specific Function:
Not Available
Gene Name:
celD
Uniprot ID:
P26221
Molecular Weight:
95201.875 Da
Kind
Protein
Organism
Escherichia coli
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Not Available
Gene Name:
stx2eB
Uniprot ID:
Q47644
Molecular Weight:
9650.1 Da

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Chloride ion binding
Specific Function:
Not Available
Gene Name:
AMY2A
Uniprot ID:
P04746
Molecular Weight:
57706.51 Da
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23