Pramiconazole
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Pramiconazole
- DrugBank Accession Number
- DB06295
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 659.739
Monoisotopic: 659.30315909 - Chemical Formula
- C35H39F2N7O4
- Synonyms
- Pramiconazole
- External IDs
- R-126638
- R126638
Pharmacology
- Indication
Investigated for use/treatment in seborrhea, fungal infections, skin infections/disorders, and onychomycosis.
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- International/Other Brands
- Azoline
Categories
- Drug Categories
- Not Available
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Diazinanes
- Sub Class
- Piperazines
- Direct Parent
- Phenylpiperazines
- Alternative Parents
- N-arylpiperazines / Phenylimidazolidines / Aminophenyl ethers / Aniline and substituted anilines / Dialkylarylamines / Phenoxy compounds / Fluorobenzenes / Alkyl aryl ethers / Imidazolidinones / Aryl fluorides show 12 more
- Substituents
- 1,2,4-triazole / Acetal / Alkyl aryl ether / Amine / Aminophenyl ether / Aniline or substituted anilines / Aromatic heteromonocyclic compound / Aryl fluoride / Aryl halide / Azacycle show 30 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 4SYH0R661F
- CAS number
- 219923-85-0
- InChI Key
- AEKNYBWUEYNWMJ-QWOOXDRHSA-N
- InChI
- InChI=1S/C35H39F2N7O4/c1-25(2)43-17-18-44(34(43)45)29-6-4-27(5-7-29)40-13-15-41(16-14-40)28-8-10-30(11-9-28)46-20-33-47-22-35(48-33,21-42-24-38-23-39-42)31-12-3-26(36)19-32(31)37/h3-12,19,23-25,33H,13-18,20-22H2,1-2H3/t33-,35+/m0/s1
- IUPAC Name
- 1-{4-[4-(4-{[(2S,4R)-4-(2,4-difluorophenyl)-4-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-2-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-3-(propan-2-yl)imidazolidin-2-one
- SMILES
- CC(C)N1CCN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@H]2OC[C@@](CN3C=NC=N3)(O2)C2=CC=C(F)C=C2F)C=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 2281806
- ChEMBL
- CHEMBL175633
- ZINC
- ZINC000003920372
- Wikipedia
- Pramiconazole
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0214 mg/mL ALOGPS logP 4.53 ALOGPS logP 5.08 Chemaxon logS -4.5 ALOGPS pKa (Strongest Basic) 3.94 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 8 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 88.43 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 188.77 m3·mol-1 Chemaxon Polarizability 69.62 Å3 Chemaxon Number of Rings 7 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 241.01906 predictedDeepCCS 1.0 (2019) [M+H]+ 242.84392 predictedDeepCCS 1.0 (2019) [M+Na]+ 248.44975 predictedDeepCCS 1.0 (2019)
Drug created at March 19, 2008 16:22 / Updated at February 21, 2021 18:52