rsPSMA Vaccine

Identification

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Name
rsPSMA Vaccine
Accession Number
DB06361
Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Vaccines
Subunit
Description

Prostate-specific membrane antigen (PSMA) is an ∼100 kDa transmembrane glycoprotein that is abundantly and preferentially expressed in prostate cancer, including recurrent and hormone-refractory cases. rsPSMA Vaccine is a subunit vaccine based on a novel rsPSMA protein that represents the entire extracellular domain of PSMA (Schulke et al., PNAS 100:12590, 2003). The vaccine comprises purified rsPSMA protein formulated with Alhydrogel® adjuvant. In preclinical studies, rsPSMA elicited high-titer antibodies that strongly cross-reacted with prostate cancer cells. 1

Synonyms
  • Recombinant soluble prostate-specific membrane antigen (rsPSMA) vaccine
  • rsPSMA
Categories
Not Available
UNII
Not Available
CAS number
Not Available

Pharmacology

Indication

Investigated for use/treatment in prostate cancer.

Pharmacodynamics
Not Available
Mechanism of action

rsPSMA vaccine with Alhydrogel demonstrated safety and tolerability in addition to the induction of high-titer PSMA-specific antibodies (Abs) by ELISA with specificity directed to cell-surface, native PSMA as indicated by FACS analysis using cells expressing PSMA.

Like native, cell-surface PSMA, the rsPSMA protein was discovered to form a noncovalent dimer, and only the dimeric form of rsPSMA was enzymatically active and capable of inducing high levels of antibodies that cross-react with PSMA-expressing tumor cells. The findings provide important proof-of-concept for our rsPSMA vaccine

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Recombinant soluble prostate-specific membrane antigen (rsPSMA) vaccine [Link]
External Links
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentAstrocytomas / Oligoastrocytoma / Oligodendrogliomas1
1Active Not RecruitingTreatmentCancer, Breast1
1Active Not RecruitingTreatmentFollicular Lymphoma (FL)1
1Active Not RecruitingTreatmentMelanoma1
1Active Not RecruitingTreatmentStage III Colon Cancer1
1CompletedNot AvailableChronic Obstructive Pulmonary Disease (COPD)1
1CompletedPreventionClostridium Infections1
1CompletedPreventionCytomegalovirus1
1CompletedPreventionFlu caused by Influenza1
1CompletedTreatmentAlzheimer's Disease (AD)1
1CompletedTreatmentBrain Stem Gliomas / Glioblastomas1
1CompletedTreatmentBrain and Central Nervous System Tumors1
1CompletedTreatmentChronic Lymphocytic Leukaemia (CLL)1
1CompletedTreatmentHealthy Volunteers1
1CompletedTreatmentLeukemias1
1CompletedTreatmentLung Cancers1
1CompletedTreatmentMalignant Gliomas1
1CompletedTreatmentMelanoma1
1CompletedTreatmentNY-ESO-1-expressing Tumors1
1CompletedTreatmentProstate Cancer1
1Enrolling by InvitationPreventionPlasmodium Infections1
1RecruitingPreventionTuberculosis Infection1
1RecruitingTreatmentGlioblastomas / Malignant Gliomas / Recurrent Brain Neoplasm / Refractory Brain Neoplasm1
1TerminatedPreventionAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) Infections1
1TerminatedPreventionHuman Immunodeficiency Virus (HIV) Infections1
1TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1Unknown StatusTreatmentHepatocellular,Carcinoma1
1WithdrawnPreventionFlu caused by Influenza1
1WithdrawnTreatmentAcute Myelogenous Leukaemia (AML)1
1WithdrawnTreatmentHead and Neck Squamous Cell Carcinoma (HNSCC)1
1, 2Active Not RecruitingTreatmentCancer, Breast1
1, 2Active Not RecruitingTreatmentCancer, Breast / DCIS Breast Cancer1
1, 2CompletedPreventionPlasmodium Falciparum Malaria1
1, 2CompletedTreatmentHigh Grade Cervical Intraepithelial Neoplasia1
1, 2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
1, 2CompletedTreatmentMelanoma (Skin)1
1, 2CompletedTreatmentType 1 Insulin-Dependent Diabetes Mellitus1
1, 2RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2RecruitingTreatmentNeuroblastomas1
1, 2TerminatedTreatmentChronic Lymphocytic Leukaemia (CLL)1
1, 2TerminatedTreatmentGliomas / Medulloblastomas / Neuroectodermal Tumors, Primitive1
1, 2TerminatedTreatmentRenal Cancers1
2Active Not RecruitingPreventionEncephalomyelitis, Venezuelan Equine1
2Active Not RecruitingPreventionStaphylococcal Vaccines1
2Active Not RecruitingTreatmentNasopharyngeal Carcinoma1
2Active Not RecruitingTreatmentPancreatic Adenocarcinoma Metastatic1
2CompletedNot AvailableBotulism1
2CompletedPreventionAcellular Pertussis / Diphtheria / Haemophilus Influenzae Type B / Pneumococcal Diseases / Poliomyelitis / Tetanus / Viral Hepatitis B1
2CompletedPreventionCholera / Severe or persistent diarrhea / Vibrio Infections1
2CompletedPreventionFlu caused by Influenza1
2CompletedPreventionHepatitis A / Prophylaxis Pneumococcal Vaccine1
2CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections1
2CompletedPreventionInfections, Rotavirus1
2CompletedPreventionMeningococcal Infections3
2CompletedPreventionMeningococcal Infections / Meningococcal Serogroup Diseases2
2CompletedPreventionMeningococcal Vaccines1
2CompletedPreventionPneumococcal Diseases / Streptococcal Infections1
2CompletedPreventionProphylaxis of Avian Influenza Vaccine1
2CompletedPreventionRabies1
2CompletedTreatmentLung Cancers1
2CompletedTreatmentMalignancies / Prostate1
2CompletedTreatmentMelanoma1
2CompletedTreatmentMelanoma (Skin)1
2CompletedTreatmentSystemic Lupus Erythematosus (SLE)1
2RecruitingTreatmentMalignant Melanoma of Skin Stage III / Malignant Melanoma of Skin Stage IV1
2TerminatedPreventionCholera / Severe or persistent diarrhea / Vibrio Infections1
2TerminatedTreatmentMalignant Melanoma1
2Unknown StatusPreventionInfections, Cytomegalovirus1
2Unknown StatusTreatmentLung Cancers1
2WithdrawnTreatmentLocally Advanced Pancreatic Cancer / Pancreatic Carcinoma Stage I1
2, 3CompletedPreventionHealthy Volunteers1
2, 3RecruitingPreventionInfluenza, Human1
3CompletedPreventionCardiovascular Disease (CVD) / Cardiovascular Surgical Procedures / Infection caused by staphylococci1
3CompletedPreventionChronic Renal Failure (CRF) / Infection caused by staphylococci1
3CompletedPreventionFlu caused by Influenza1
3CompletedPreventionFlu caused by Influenza / Seasonal Influenza1
3CompletedPreventionHaemophilus Influenzae Type B / Haemophilus Influenzae Type b Diseases / Meningococcal Serogroup C Diseases / Neisseria Meningitidis1
3CompletedPreventionHaemophilus Influenzae Type B / Haemophilus Influenzae Type b Diseases / Meningococcal Serogroup Diseases / Neisseria Meningitidis2
3CompletedPreventionHaemophilus Influenzae Type B / Neisseria Meningitidis3
3CompletedPreventionInfection caused by staphylococci1
3CompletedPreventionInfections, Rotavirus1
3CompletedPreventionPneumococcal Diseases / Streptococcal Infections2
3CompletedPreventionProphylaxis Pneumococcal Vaccine1
3CompletedPreventionStreptococcal Infections2
3CompletedTreatmentInflammatory Bowel Diseases (IBD)1
3RecruitingPreventionHerpes Zoster1
3TerminatedPreventionInfluenza Infection1
4Active Not RecruitingPreventionEbola Virus Disease / Prevention1
4Active Not RecruitingPreventionHand, Foot and Mouth Disease (HFMD)1
4Active Not RecruitingPreventionSystemic Lupus Erythematosus (SLE)1
4Active Not RecruitingTreatmentHepatitis B Chronic Infection1
4CompletedNot AvailableFlu caused by Influenza1
4CompletedBasic ScienceEncephalitis, Japanese B / Japanese Encephalitis Vaccine1
4CompletedPreventionChronic Obstructive Pulmonary Disease (COPD)1
4CompletedPreventionFlu caused by Influenza2
4CompletedPreventionHand, Foot and Mouth Disease (HFMD)1
4CompletedPreventionHeart Failure1
4CompletedPreventionInfection NOS1
4CompletedPreventionVibrio Cholerae1
4CompletedTreatmentAllergies1
4CompletedTreatmentEnd Stage Renal Disease (ESRD)1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4Unknown StatusPreventionFlu caused by Influenza1
Not AvailableActive Not RecruitingBasic ScienceYellow Fever1
Not AvailableActive Not RecruitingOtherUveal Melanoma1
Not AvailableActive Not RecruitingTreatmentNasopharyngeal Carcinoma1
Not AvailableCompletedBasic ScienceHealthy Volunteers1
Not AvailableCompletedBasic ScienceImmunity to Influenza Vaccine1
Not AvailableCompletedPreventionFlu caused by Influenza1
Not AvailableCompletedPreventionHepatitis B Chronic Infection1
Not AvailableCompletedPreventionNasopharyngeal Diseases / Streptococcal Pneumonia / Vaccination Adverse Events1
Not AvailableWithdrawnDiagnosticCancer, Breast1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Taxonomy

Classification
Not classified

Drug created on March 19, 2008 10:27 / Updated on June 04, 2019 06:23