2-METHYLTHIO-N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE

Identification

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Name
2-METHYLTHIO-N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE
Accession Number
DB08185
Type
Small Molecule
Groups
Experimental
Description
Not Available
Structure
Thumb
Synonyms
Not Available
Categories
Not Available
UNII
Not Available
CAS number
Not Available
Weight
Average: 463.446
Monoisotopic: 463.129055413
Chemical Formula
C16H26N5O7PS
InChI Key
LCHGAOHLDYRACA-SDBHATRESA-N
InChI
InChI=1S/C16H26N5O7PS/c1-8(2)4-5-17-13-10-14(20-16(19-13)30-3)21(7-18-10)15-12(23)11(22)9(28-15)6-27-29(24,25)26/h7-9,11-12,15,22-23H,4-6H2,1-3H3,(H,17,19,20)(H2,24,25,26)/t9-,11-,12-,15-/m1/s1
IUPAC Name
{[(2R,3S,4R,5R)-3,4-dihydroxy-5-{6-[(3-methylbutyl)amino]-2-(methylsulfanyl)-9H-purin-9-yl}oxolan-2-yl]methoxy}phosphonic acid
SMILES
[H][C@]1(COP(O)(O)=O)O[C@@]([H])(N2C=NC3=C2N=C(SC)N=C3NCCC(C)C)[C@]([H])(O)[C@]1([H])O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UElongation factor TuNot AvailableThermus aquaticus
U30S ribosomal protein S12Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S10Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S11Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S13Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S14 type ZNot AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S15Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S16Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S17Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S18Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S19Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S20Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S4Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S5Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S6Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S7Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S8Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S9Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein ThxNot AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S17Not AvailableThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
U30S ribosomal protein S20Not AvailableThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
U30S ribosomal protein S2Not AvailableThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
U30S ribosomal protein S3Not AvailableThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
U30S ribosomal protein S9Not AvailableThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
U30S ribosomal protein S19Not AvailableThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
U30S ribosomal protein S2Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
U30S ribosomal protein S3Not AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
46937130
PubChem Substance
99444656
ChemSpider
25060716
HET
MIA
PDB Entries
1b23 / 1vy4 / 1vy5 / 3bbv / 3j46 / 4cxg / 4cxh / 4uje / 4v4i / 4v5l
show 53 more

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.71 mg/mLALOGPS
logP0.64ALOGPS
logP-1.2ChemAxon
logS-2.4ALOGPS
pKa (Strongest Acidic)1.23ChemAxon
pKa (Strongest Basic)3.99ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area172.08 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity110.69 m3·mol-1ChemAxon
Polarizability45.75 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.9002
Blood Brain Barrier-0.7968
Caco-2 permeable-0.6488
P-glycoprotein substrateSubstrate0.6575
P-glycoprotein inhibitor INon-inhibitor0.735
P-glycoprotein inhibitor IINon-inhibitor0.9676
Renal organic cation transporterNon-inhibitor0.9284
CYP450 2C9 substrateNon-substrate0.7352
CYP450 2D6 substrateNon-substrate0.7867
CYP450 3A4 substrateSubstrate0.6009
CYP450 1A2 substrateNon-inhibitor0.7075
CYP450 2C9 inhibitorNon-inhibitor0.7085
CYP450 2D6 inhibitorNon-inhibitor0.8359
CYP450 2C19 inhibitorNon-inhibitor0.7008
CYP450 3A4 inhibitorNon-inhibitor0.8292
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.801
Ames testNon AMES toxic0.5966
CarcinogenicityNon-carcinogens0.8429
BiodegradationNot ready biodegradable0.9843
Rat acute toxicity2.5365 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9757
hERG inhibition (predictor II)Non-inhibitor0.6428
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached.
Kingdom
Organic compounds
Super Class
Nucleosides, nucleotides, and analogues
Class
Purine nucleotides
Sub Class
Purine ribonucleotides
Direct Parent
Purine ribonucleoside monophosphates
Alternative Parents
Pentose phosphates / 6-alkylaminopurines / Glycosylamines / Monosaccharide phosphates / Secondary alkylarylamines / Alkylarylthioethers / Aminopyrimidines and derivatives / Monoalkyl phosphates / N-substituted imidazoles / Imidolactams
show 10 more
Substituents
Purine ribonucleoside monophosphate / Pentose phosphate / Pentose-5-phosphate / Glycosyl compound / N-glycosyl compound / 6-alkylaminopurine / 6-aminopurine / Monosaccharide phosphate / Pentose monosaccharide / Imidazopyrimidine
show 36 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Thermus aquaticus
Pharmacological action
Unknown
General Function
Translation elongation factor activity
Specific Function
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Gene Name
tuf
Uniprot ID
Q01698
Uniprot Name
Elongation factor Tu
Molecular Weight
44814.085 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Trna binding
Specific Function
With S4 and S5 plays an important role in translational accuracy.Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone (Pu...
Gene Name
rpsL
Uniprot ID
Q5SHN3
Uniprot Name
30S ribosomal protein S12
Molecular Weight
14599.205 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Trna binding
Specific Function
Part of the top of the 30S subunit head.
Gene Name
rpsJ
Uniprot ID
Q5SHN7
Uniprot Name
30S ribosomal protein S10
Molecular Weight
11929.82 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
Located on the upper part of the platform of the 30S subunit, where it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome, where it in...
Gene Name
rpsK
Uniprot ID
P80376
Uniprot Name
30S ribosomal protein S11
Molecular Weight
13712.74 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Trna binding
Specific Function
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome structure it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit...
Gene Name
rpsM
Uniprot ID
P80377
Uniprot Name
30S ribosomal protein S13
Molecular Weight
14304.645 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity). Binds 16S rRNA in center of the 30S subunit head.
Specific Function
Metal ion binding
Gene Name
rpsZ
Uniprot ID
P0DOY6
Uniprot Name
30S ribosomal protein S14 type Z
Molecular Weight
7139.57 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rR...
Gene Name
rpsO
Uniprot ID
Q5SJ76
Uniprot Name
30S ribosomal protein S15
Molecular Weight
10554.28 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
Binds to the lower part of the body of the 30S subunit, where it stabilizes two of its domains.
Gene Name
rpsP
Uniprot ID
Q5SJH3
Uniprot Name
30S ribosomal protein S16
Molecular Weight
10386.855 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform and body of the 30S subunit by bringing together and stabilizing interactions between several different RNA helices. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
Specific Function
Rrna binding
Gene Name
rpsQ
Uniprot ID
P0DOY7
Uniprot Name
30S ribosomal protein S17
Molecular Weight
12297.52 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
Located on the back of the platform of the 30S subunit where it stabilizes the close packing of several RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome, wher...
Gene Name
rpsR
Uniprot ID
Q5SLQ0
Uniprot Name
30S ribosomal protein S18
Molecular Weight
10231.105 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
Located at the top of the head of the 30S subunit, extending towards the 50S subunit, which it may contact in the 70S complex. Contacts several RNA helices of the 16S rRNA.
Gene Name
rpsS
Uniprot ID
Q5SHP2
Uniprot Name
30S ribosomal protein S19
Molecular Weight
10581.38 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the bottom of the body of the 30S subunit, by binding to several RNA helices of the 16S rRNA.
Gene Name
rpsT
Uniprot ID
P80380
Uniprot Name
30S ribosomal protein S20
Molecular Weight
11702.885 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the body and platform of the 30S subunit. Binds mRNA in the 70S ribosome, positioning it ...
Gene Name
rpsD
Uniprot ID
P80373
Uniprot Name
30S ribosomal protein S4
Molecular Weight
24324.11 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
With S4 and S12 plays an important role in translational accuracy.Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Binds mRNA i...
Gene Name
rpsE
Uniprot ID
Q5SHQ5
Uniprot Name
30S ribosomal protein S5
Molecular Weight
17557.285 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
Located on the outer edge of the platform on the body of the 30S subunit.
Gene Name
rpsF
Uniprot ID
Q5SLP8
Uniprot Name
30S ribosomal protein S6
Molecular Weight
11972.67 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Trna binding
Specific Function
One of the primary rRNA binding proteins, it binds directly to 3'-end of the 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to...
Gene Name
rpsG
Uniprot ID
P17291
Uniprot Name
30S ribosomal protein S7
Molecular Weight
18015.785 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit central domain. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
Specific Function
Rrna binding
Gene Name
rpsH
Uniprot ID
P0DOY9
Uniprot Name
30S ribosomal protein S8
Molecular Weight
15837.365 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Trna binding
Specific Function
Part of the top of the head of the 30S subunit. The C-terminal region penetrates the head emerging in the P-site where it contacts tRNA.
Gene Name
rpsI
Uniprot ID
P80374
Uniprot Name
30S ribosomal protein S9
Molecular Weight
14382.485 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Rrna binding
Specific Function
Binds at the top of the head of the 30S subunit. It stabilizes a number of different RNA elements and thus is important for subunit structure.
Gene Name
rpsU
Uniprot ID
Q5SIH3
Uniprot Name
30S ribosomal protein Thx
Molecular Weight
3336.96 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
Gene Name
rpsQ
Uniprot ID
P62658
Uniprot Name
30S ribosomal protein S17
Molecular Weight
12296.54 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
Binds directly to 16S ribosomal RNA.
Gene Name
rpsT
Uniprot ID
P62661
Uniprot Name
30S ribosomal protein S20
Molecular Weight
11688.865 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit (By similarity).
Gene Name
rpsB
Uniprot ID
P62662
Uniprot Name
30S ribosomal protein S2
Molecular Weight
29276.395 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity).
Gene Name
rpsC
Uniprot ID
P62663
Uniprot Name
30S ribosomal protein S3
Molecular Weight
26700.81 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Pharmacological action
Unknown
General Function
Trna binding
Specific Function
Part of the top of the head of the 30S subunit. The C-terminal region penetrates the head emerging in the P-site where it contacts tRNA (By similarity).
Gene Name
rpsI
Uniprot ID
P62669
Uniprot Name
30S ribosomal protein S9
Molecular Weight
14401.525 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
Gene Name
rpsS
Uniprot ID
P62660
Uniprot Name
30S ribosomal protein S19
Molecular Weight
10581.38 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit.
Gene Name
rpsB
Uniprot ID
P80371
Uniprot Name
30S ribosomal protein S2
Molecular Weight
29276.395 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Structural constituent of ribosome
Specific Function
Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
Gene Name
rpsC
Uniprot ID
P80372
Uniprot Name
30S ribosomal protein S3
Molecular Weight
26700.81 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]

Drug created on September 15, 2010 15:29 / Updated on June 04, 2019 06:54