Dextran 40

Identification

Name
Dextran 40
Accession Number
DB11122
Type
Small Molecule
Groups
Approved
Description

Dextran 40 is a sterile, nonpyrogenic preparation of low molecular weight dextran (average mol. wt. 40,000) in 5% Dextrose Injection or 0.9% Sodium Chloride Injection. It is administered by intravenous infusion.

Synonyms
Not Available
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
LMD in DextroseInjection, solution10 g/100mLIntravenousHospira, Inc.1992-10-30Not applicableUs
LMD in Sodium ChlorideInjection, solution10 g/100mLIntravenousHospira, Inc.1992-10-30Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
10% Dextran 40 In 0.9% Sodium Chloride InjectionDextran 40 (10 %) + Sodium Chloride (0.9 %)SolutionIntravenousB. Braun Medical Inc.1993-12-31Not applicableCanada
10% Dextran 40 In 5% Dextrose InjectionDextran 40 (10 %) + Glucose (5 %)SolutionIntravenousB. Braun Medical Inc.1996-09-10Not applicableCanada
Ocutears DropsDextran 40 (.1 %) + Hypromellose (.5 %)Solution / dropsOphthalmicLaboratoires Charton Laboratories1988-12-311999-01-16Canada
Categories
UNII
K3R6ZDH4DU
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Dextran 40 is indicated for use in the adjunctive treatment of shock or impending shock due to hemorrhage, burns, surgery or other trauma. Also, indicated for use as a priming fluid, either as a sole prime or as an additive, in pump oxygenators during extracorporeal circulation. Dextran 40 is also indicated for use in prophylaxis of venous thrombosis and pulmonary embolism in patients undergoing procedures known to be associated with a high incidence of thromboembolic complications, such as hip surgery.

Structured Indications
Pharmacodynamics

The fundamental action of dextran 40 is the enhancement of blood flow, particularly in the microcirculation. This enhancement is due to: 1. Its primary effect of volume expansion with resultant hemodilution; 2. Maintenance of the electronegativity of red blood cells; 3.Coating of red blood cells and platelets; 4.Increase in the suspension stability of blood; 5.Decrease in the viscosity of blood. It should be emphasized that the above effects are not exerted separately, but conjointly they result in the enhancement of blood flow.

Mechanism of action
Not Available
Absorption

Maximum plasma volume reached within several minutes after the end of the infusion.

Volume of distribution

Evenly distributed in the vascular system.

Protein binding
Not Available
Metabolism

Large, unexcreted molecules (molecular weight ≥50,000) slowly degraded by dextranase enzyme to glucose which is metabolized to carbon dioxide and water.

Route of elimination

In normovolemic patients, principally excreted unchanged in urine (approximately 75%) within 24 hours; small amounts eliminated in feces.

Half life

10 hours

Clearance
Not Available
Toxicity

Women : TDLo ( intravenous) 6mg/kg : Effects- Dermatits Mouse : LD50 ( Oral) >12 gm/kg Rabit : LD50 ( intravenous) 208gm/kg

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limonene(4R)-limonene may increase the anticoagulant activities of Dextran 40.Investigational
AbciximabAbciximab may increase the anticoagulant activities of Dextran 40.Approved
AceclofenacAceclofenac may increase the anticoagulant activities of Dextran 40.Approved, Investigational
AcemetacinThe risk or severity of bleeding can be increased when Dextran 40 is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolAcenocoumarol may increase the anticoagulant activities of Dextran 40.Approved, Investigational
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Dextran 40.Approved, Vet Approved
AdapaleneAdapalene may increase the anticoagulant activities of Dextran 40.Approved
AlclofenacAlclofenac may increase the anticoagulant activities of Dextran 40.Approved, Withdrawn
AllylestrenolThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Allylestrenol.Approved
AlminoprofenAlminoprofen may increase the anticoagulant activities of Dextran 40.Experimental
AloxiprinAloxiprin may increase the anticoagulant activities of Dextran 40.Experimental
AlprostadilAlprostadil may increase the anticoagulant activities of Dextran 40.Approved, Investigational
AlteplaseAlteplase may increase the anticoagulant activities of Dextran 40.Approved
AltrenogestThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Altrenogest.Vet Approved
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Dextran 40.Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Dextran 40.Approved
AncrodAncrod may increase the anticoagulant activities of Dextran 40.Approved, Investigational
AndrographolideAndrographolide may increase the anticoagulant activities of Dextran 40.Investigational
AnisodamineAnisodamine may increase the anticoagulant activities of Dextran 40.Investigational
AnistreplaseAnistreplase may increase the anticoagulant activities of Dextran 40.Approved
AntipyrineAntipyrine may increase the anticoagulant activities of Dextran 40.Approved, Investigational
Antithrombin III humanDextran 40 may increase the anticoagulant activities of Antithrombin III human.Approved
ApixabanApixaban may increase the anticoagulant activities of Dextran 40.Approved
ApocyninApocynin may increase the anticoagulant activities of Dextran 40.Investigational
ApremilastApremilast may increase the anticoagulant activities of Dextran 40.Approved, Investigational
ArdeparinArdeparin may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Withdrawn
ArgatrobanArgatroban may increase the anticoagulant activities of Dextran 40.Approved, Investigational
AstaxanthinAstaxanthin may increase the anticoagulant activities of Dextran 40.Investigational
AzapropazoneAzapropazone may increase the anticoagulant activities of Dextran 40.Withdrawn
AzelastineAzelastine may increase the anticoagulant activities of Dextran 40.Approved
BalsalazideBalsalazide may increase the anticoagulant activities of Dextran 40.Approved, Investigational
BatroxobinBatroxobin may increase the anticoagulant activities of Dextran 40.Experimental
BecaplerminBecaplermin may increase the anticoagulant activities of Dextran 40.Approved, Investigational
BemiparinBemiparin may increase the anticoagulant activities of Dextran 40.Approved, Investigational
BendazacBendazac may increase the anticoagulant activities of Dextran 40.Experimental
BenorilateBenorilate may increase the anticoagulant activities of Dextran 40.Experimental
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Dextran 40.Withdrawn
BenzydamineBenzydamine may increase the anticoagulant activities of Dextran 40.Approved
BeraprostBeraprost may increase the anticoagulant activities of Dextran 40.Investigational
BevoniumBevonium may increase the anticoagulant activities of Dextran 40.Experimental
BivalirudinBivalirudin may increase the anticoagulant activities of Dextran 40.Approved, Investigational
BrinaseBrinase may increase the anticoagulant activities of Dextran 40.Experimental
BromfenacBromfenac may increase the anticoagulant activities of Dextran 40.Approved
BucillamineBucillamine may increase the anticoagulant activities of Dextran 40.Investigational
BufexamacBufexamac may increase the anticoagulant activities of Dextran 40.Approved, Experimental
BuflomedilBuflomedil may increase the anticoagulant activities of Dextran 40.Experimental
BumadizoneBumadizone may increase the anticoagulant activities of Dextran 40.Experimental
ButylphthalideButylphthalide may increase the anticoagulant activities of Dextran 40.Investigational
CangrelorCangrelor may increase the anticoagulant activities of Dextran 40.Approved
CaplacizumabCaplacizumab may increase the anticoagulant activities of Dextran 40.Investigational
Carbaspirin calciumCarbaspirin calcium may increase the anticoagulant activities of Dextran 40.Experimental, Investigational
CarprofenCarprofen may increase the anticoagulant activities of Dextran 40.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may increase the anticoagulant activities of Dextran 40.Experimental
CelecoxibCelecoxib may increase the anticoagulant activities of Dextran 40.Approved, Investigational
CertoparinCertoparin may increase the anticoagulant activities of Dextran 40.Approved, Investigational
ChloroquineChloroquine may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Vet Approved
ChlorotrianiseneChlorotrianisene may decrease the anticoagulant activities of Dextran 40.Investigational, Withdrawn
Choline magnesium trisalicylateCholine magnesium trisalicylate may increase the anticoagulant activities of Dextran 40.Approved
CilostazolCilostazol may increase the anticoagulant activities of Dextran 40.Approved, Investigational
Citric AcidCitric Acid may increase the anticoagulant activities of Dextran 40.Approved, Nutraceutical, Vet Approved
ClonixinClonixin may increase the anticoagulant activities of Dextran 40.Approved
ClopidogrelClopidogrel may increase the anticoagulant activities of Dextran 40.Approved
CloricromenCloricromen may increase the anticoagulant activities of Dextran 40.Experimental
ClorindioneClorindione may increase the anticoagulant activities of Dextran 40.Experimental
Collagenase clostridium histolyticumThe risk or severity of adverse effects can be increased when Dextran 40 is combined with Collagenase clostridium histolyticum.Approved, Investigational
Conjugated estrogensConjugated estrogens may decrease the anticoagulant activities of Dextran 40.Approved
CurcuminCurcumin may increase the anticoagulant activities of Dextran 40.Approved, Investigational
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Dextran 40.Approved
DaidzeinDaidzein may decrease the anticoagulant activities of Dextran 40.Experimental
DalteparinDalteparin may increase the anticoagulant activities of Dextran 40.Approved
DanaparoidDanaparoid may increase the anticoagulant activities of Dextran 40.Approved, Withdrawn
DarexabanDextran 40 may increase the anticoagulant activities of Darexaban.Investigational
DasatinibDasatinib may increase the anticoagulant activities of Dextran 40.Approved, Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Dextran 40 is combined with Deferasirox.Approved, Investigational
DefibrotideDefibrotide may increase the anticoagulant activities of Dextran 40.Approved, Investigational
DemegestoneThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Demegestone.Experimental
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Dextran 40 is combined with Deoxycholic Acid.Approved
DersalazineDersalazine may increase the anticoagulant activities of Dextran 40.Investigational
DesirudinDesirudin may increase the anticoagulant activities of Dextran 40.Approved
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Dextran 40.Investigational
DesogestrelThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Desogestrel.Approved
DextranDextran may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Vet Approved
Dextran 70Dextran 70 may increase the anticoagulant activities of Dextran 40.Approved
Dextran 75Dextran 40 may increase the anticoagulant activities of Dextran 75.Approved
DiclofenacDiclofenac may increase the anticoagulant activities of Dextran 40.Approved, Vet Approved
DicoumarolDicoumarol may increase the anticoagulant activities of Dextran 40.Approved
DienestrolDienestrol may decrease the anticoagulant activities of Dextran 40.Approved, Investigational
DienogestThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Dienogest.Approved
DiethylstilbestrolDiethylstilbestrol may decrease the anticoagulant activities of Dextran 40.Approved, Investigational
DifenpiramideDifenpiramide may increase the anticoagulant activities of Dextran 40.Experimental
DiflunisalDiflunisal may increase the anticoagulant activities of Dextran 40.Approved, Investigational
DiphenadioneDiphenadione may increase the anticoagulant activities of Dextran 40.Experimental
DipyridamoleDipyridamole may increase the anticoagulant activities of Dextran 40.Approved
DitazoleDitazole may increase the anticoagulant activities of Dextran 40.Approved, Withdrawn
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Withdrawn
DroxicamDroxicam may increase the anticoagulant activities of Dextran 40.Withdrawn
DuvelisibDuvelisib may increase the anticoagulant activities of Dextran 40.Investigational
DydrogesteroneThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Dydrogesterone.Approved, Investigational, Withdrawn
E-6201E-6201 may increase the anticoagulant activities of Dextran 40.Investigational
Edetic AcidEdetic Acid may increase the anticoagulant activities of Dextran 40.Approved, Vet Approved
EdoxabanEdoxaban may increase the anticoagulant activities of Dextran 40.Approved
EnoxaparinEnoxaparin may increase the anticoagulant activities of Dextran 40.Approved
EpimestrolEpimestrol may decrease the anticoagulant activities of Dextran 40.Experimental
EpinastineEpinastine may increase the anticoagulant activities of Dextran 40.Approved, Investigational
EpirizoleEpirizole may increase the anticoagulant activities of Dextran 40.Approved
EplivanserinEplivanserin may increase the anticoagulant activities of Dextran 40.Investigational
eplivanserineeplivanserine may increase the anticoagulant activities of Dextran 40.Investigational
EpoprostenolEpoprostenol may increase the anticoagulant activities of Dextran 40.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Dextran 40.Approved, Investigational
EquolEquol may decrease the anticoagulant activities of Dextran 40.Investigational
EstradiolEstradiol may decrease the anticoagulant activities of Dextran 40.Approved, Investigational, Vet Approved
Estradiol acetateEstradiol acetate may decrease the anticoagulant activities of Dextran 40.Approved, Investigational, Vet Approved
Estradiol cypionateEstradiol cypionate may decrease the anticoagulant activities of Dextran 40.Approved, Investigational, Vet Approved
Estradiol valerateEstradiol valerate may decrease the anticoagulant activities of Dextran 40.Approved, Investigational, Vet Approved
EstriolEstriol may decrease the anticoagulant activities of Dextran 40.Approved, Investigational, Vet Approved
Estrogens, esterifiedEstrogens, esterified may decrease the anticoagulant activities of Dextran 40.Approved
EstroneEstrone may decrease the anticoagulant activities of Dextran 40.Approved
EtanerceptEtanercept may increase the anticoagulant activities of Dextran 40.Approved, Investigational
EthenzamideEthenzamide may increase the anticoagulant activities of Dextran 40.Experimental
Ethinyl EstradiolEthinyl Estradiol may decrease the anticoagulant activities of Dextran 40.Approved
Ethyl biscoumacetateEthyl biscoumacetate may increase the anticoagulant activities of Dextran 40.Withdrawn
EtodolacEtodolac may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the anticoagulant activities of Dextran 40.Approved, Investigational
EtonogestrelThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Etonogestrel.Approved, Investigational
EtoricoxibEtoricoxib may increase the anticoagulant activities of Dextran 40.Approved, Investigational
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Dextran 40.Approved, Investigational
ExisulindExisulind may increase the anticoagulant activities of Dextran 40.Investigational
FelbinacFelbinac may increase the anticoagulant activities of Dextran 40.Experimental
FenbufenFenbufen may increase the anticoagulant activities of Dextran 40.Approved
FenoprofenFenoprofen may increase the anticoagulant activities of Dextran 40.Approved
FentiazacFentiazac may increase the anticoagulant activities of Dextran 40.Experimental
FeprazoneFeprazone may increase the anticoagulant activities of Dextran 40.Experimental
Ferulic acidFerulic acid may increase the anticoagulant activities of Dextran 40.Experimental
FibrinolysinFibrinolysin may increase the anticoagulant activities of Dextran 40.Investigational
FloctafenineFloctafenine may increase the anticoagulant activities of Dextran 40.Approved, Withdrawn
FluindioneDextran 40 may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlunixinFlunixin may increase the anticoagulant activities of Dextran 40.Vet Approved
FlunoxaprofenFlunoxaprofen may increase the anticoagulant activities of Dextran 40.Experimental
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Dextran 40.Approved, Investigational
FondaparinuxDextran 40 may increase the anticoagulant activities of Fondaparinux.Approved, Investigational
Fondaparinux sodiumFondaparinux sodium may increase the anticoagulant activities of Dextran 40.Approved, Investigational
GabexateDextran 40 may increase the anticoagulant activities of Gabexate.Investigational
GenisteinGenistein may decrease the anticoagulant activities of Dextran 40.Investigational
GestodeneThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Gestodene.Approved, Investigational
GestonoroneThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Gestonorone.Experimental
GestrinoneThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Gestrinone.Approved
GuacetisalGuacetisal may increase the anticoagulant activities of Dextran 40.Experimental
HeminHemin may increase the anticoagulant activities of Dextran 40.Approved, Investigational
Hemoglobin crosfumarilHemoglobin crosfumaril may increase the anticoagulant activities of Dextran 40.Experimental
HeparinHeparin may increase the anticoagulant activities of Dextran 40.Approved, Investigational
HexestrolHexestrol may decrease the anticoagulant activities of Dextran 40.Withdrawn
HigenamineHigenamine may increase the anticoagulant activities of Dextran 40.Investigational
Hydroxyprogesterone caproateThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Hydroxyprogesterone caproate.Approved, Investigational
HydroxytyrosolHydroxytyrosol may increase the anticoagulant activities of Dextran 40.Investigational
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Dextran 40 is combined with Ibritumomab tiuxetan.Approved, Investigational
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Dextran 40.Approved
IbudilastIbudilast may increase the anticoagulant activities of Dextran 40.Approved, Investigational
IbuprofenIbuprofen may increase the anticoagulant activities of Dextran 40.Approved
IbuproxamIbuproxam may increase the anticoagulant activities of Dextran 40.Withdrawn
IcatibantIcatibant may increase the anticoagulant activities of Dextran 40.Approved, Investigational
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Nutraceutical
IdraparinuxIdraparinux may increase the anticoagulant activities of Dextran 40.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Withdrawn
IfetrobanIfetroban may increase the anticoagulant activities of Dextran 40.Investigational
IloprostIloprost may increase the anticoagulant activities of Dextran 40.Approved, Investigational
Imidazole salicylateImidazole salicylate may increase the anticoagulant activities of Dextran 40.Experimental
IndobufenIndobufen may increase the anticoagulant activities of Dextran 40.Investigational
IndomethacinIndomethacin may increase the anticoagulant activities of Dextran 40.Approved, Investigational
IndoprofenIndoprofen may increase the anticoagulant activities of Dextran 40.Withdrawn
IsoxicamIsoxicam may increase the anticoagulant activities of Dextran 40.Withdrawn
KebuzoneKebuzone may increase the anticoagulant activities of Dextran 40.Experimental
KetanserinKetanserin may increase the anticoagulant activities of Dextran 40.Investigational
KetoprofenKetoprofen may increase the anticoagulant activities of Dextran 40.Approved, Vet Approved
KetorolacKetorolac may increase the anticoagulant activities of Dextran 40.Approved
LeflunomideLeflunomide may increase the anticoagulant activities of Dextran 40.Approved, Investigational
LepirudinLepirudin may increase the anticoagulant activities of Dextran 40.Approved
LetaxabanDextran 40 may increase the anticoagulant activities of Letaxaban.Investigational
LevonorgestrelThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Levonorgestrel.Approved, Investigational
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Dextran 40.Approved, Investigational
LinsidomineLinsidomine may increase the anticoagulant activities of Dextran 40.Experimental
LisofyllineLisofylline may increase the anticoagulant activities of Dextran 40.Investigational
LonazolacLonazolac may increase the anticoagulant activities of Dextran 40.Experimental
LornoxicamLornoxicam may increase the anticoagulant activities of Dextran 40.Approved, Investigational
LoxoprofenLoxoprofen may increase the anticoagulant activities of Dextran 40.Approved, Investigational
LumiracoxibLumiracoxib may increase the anticoagulant activities of Dextran 40.Approved, Investigational
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Dextran 40.Approved
MasoprocolMasoprocol may increase the anticoagulant activities of Dextran 40.Approved, Investigational
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Dextran 40.Approved, Vet Approved
MedrogestoneThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Medrogestone.Approved
Medroxyprogesterone acetateThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Medroxyprogesterone acetate.Approved, Investigational
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Dextran 40.Approved
Megestrol acetateThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Megestrol acetate.Approved, Investigational, Vet Approved
MelagatranDextran 40 may increase the anticoagulant activities of Melagatran.Experimental
MeloxicamMeloxicam may increase the anticoagulant activities of Dextran 40.Approved, Vet Approved
MesalazineMesalazine may increase the anticoagulant activities of Dextran 40.Approved
MestranolMestranol may decrease the anticoagulant activities of Dextran 40.Approved
MetamizoleMetamizole may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Withdrawn
MethallenestrilMethallenestril may decrease the anticoagulant activities of Dextran 40.Experimental
Methyl salicylateMethyl salicylate may increase the anticoagulant activities of Dextran 40.Approved, Vet Approved
MethylestrenoloneThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Methylestrenolone.Experimental
MilrinoneMilrinone may increase the anticoagulant activities of Dextran 40.Approved
MizoribineMizoribine may increase the anticoagulant activities of Dextran 40.Investigational
MofebutazoneMofebutazone may increase the anticoagulant activities of Dextran 40.Experimental
MoxestrolMoxestrol may decrease the anticoagulant activities of Dextran 40.Experimental
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Dextran 40.Approved, Investigational
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Dextran 40.Approved
NabumetoneNabumetone may increase the anticoagulant activities of Dextran 40.Approved
NadroparinNadroparin may increase the anticoagulant activities of Dextran 40.Approved, Investigational
NafamostatNafamostat may increase the anticoagulant activities of Dextran 40.Approved, Investigational
NaftifineNaftifine may increase the anticoagulant activities of Dextran 40.Approved
NaftopidilNaftopidil may increase the anticoagulant activities of Dextran 40.Investigational
NaproxenNaproxen may increase the anticoagulant activities of Dextran 40.Approved, Vet Approved
NepafenacNepafenac may increase the anticoagulant activities of Dextran 40.Approved, Investigational
NifenazoneNifenazone may increase the anticoagulant activities of Dextran 40.Experimental
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Dextran 40.Approved
NimesulideNimesulide may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Withdrawn
NintedanibThe risk or severity of adverse effects can be increased when Dextran 40 is combined with Nintedanib.Approved
NitroaspirinNitroaspirin may increase the anticoagulant activities of Dextran 40.Investigational
NomegestrolThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Nomegestrol.Approved
NorethisteroneThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Norethisterone.Approved
NorgestrienoneThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Norgestrienone.Experimental
ObinutuzumabThe risk or severity of adverse effects can be increased when Dextran 40 is combined with Obinutuzumab.Approved, Investigational
OlopatadineOlopatadine may increase the anticoagulant activities of Dextran 40.Approved
OlsalazineOlsalazine may increase the anticoagulant activities of Dextran 40.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Dextran 40 is combined with Omacetaxine mepesuccinate.Approved, Investigational
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Dextran 40.Approved, Nutraceutical
OrgoteinOrgotein may increase the anticoagulant activities of Dextran 40.Vet Approved
OtamixabanOtamixaban may increase the anticoagulant activities of Dextran 40.Investigational
OxaprozinOxaprozin may increase the anticoagulant activities of Dextran 40.Approved
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Dextran 40.Approved, Withdrawn
OzagrelOzagrel may increase the anticoagulant activities of Dextran 40.Investigational
ParecoxibParecoxib may increase the anticoagulant activities of Dextran 40.Approved
ParnaparinParnaparin may increase the anticoagulant activities of Dextran 40.Approved, Investigational
ParthenolideParthenolide may increase the anticoagulant activities of Dextran 40.Approved, Investigational
Pentaerythritol TetranitratePentaerythritol Tetranitrate may increase the anticoagulant activities of Dextran 40.Approved
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Dextran 40.Approved
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Dextran 40.Approved, Investigational
PhenindionePhenindione may increase the anticoagulant activities of Dextran 40.Approved, Investigational
PhenprocoumonPhenprocoumon may increase the anticoagulant activities of Dextran 40.Approved, Investigational
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Dextran 40.Approved, Vet Approved
PicotamidePicotamide may increase the anticoagulant activities of Dextran 40.Experimental
PimecrolimusPimecrolimus may increase the anticoagulant activities of Dextran 40.Approved, Investigational
PirfenidonePirfenidone may increase the anticoagulant activities of Dextran 40.Approved, Investigational
PiroxicamPiroxicam may increase the anticoagulant activities of Dextran 40.Approved, Investigational
PirprofenPirprofen may increase the anticoagulant activities of Dextran 40.Experimental
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Dextran 40.Approved
PranoprofenPranoprofen may increase the anticoagulant activities of Dextran 40.Experimental, Investigational
PrasugrelPrasugrel may increase the anticoagulant activities of Dextran 40.Approved
ProgesteroneThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Progesterone.Approved, Vet Approved
ProglumetacinProglumetacin may increase the anticoagulant activities of Dextran 40.Experimental
PromegestoneThe therapeutic efficacy of Dextran 40 can be decreased when used in combination with Promegestone.Experimental
PromestrienePromestriene may decrease the anticoagulant activities of Dextran 40.Investigational
PropacetamolPropacetamol may increase the anticoagulant activities of Dextran 40.Approved, Investigational
PropyphenazonePropyphenazone may increase the anticoagulant activities of Dextran 40.Experimental
ProquazoneProquazone may increase the anticoagulant activities of Dextran 40.Experimental
Protein CDextran 40 may increase the anticoagulant activities of Protein C.Approved
Protein S humanDextran 40 may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeDextran 40 may increase the anticoagulant activities of Protocatechualdehyde.Approved
PTC299PTC299 may increase the anticoagulant activities of Dextran 40.Investigational
QuinestrolQuinestrol may decrease the anticoagulant activities of Dextran 40.Approved
RamatrobanRamatroban may increase the anticoagulant activities of Dextran 40.Investigational
RelcovaptanRelcovaptan may increase the anticoagulant activities of Dextran 40.Investigational
ResveratrolResveratrol may increase the anticoagulant activities of Dextran 40.Approved, Experimental, Investigational
ReteplaseReteplase may increase the anticoagulant activities of Dextran 40.Approved, Investigational
ReviparinReviparin may increase the anticoagulant activities of Dextran 40.Approved, Investigational
RidogrelRidogrel may increase the anticoagulant activities of Dextran 40.Approved
RivaroxabanDextran 40 may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Withdrawn
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Dextran 40.Approved, Investigational
SalicylamideSalicylamide may increase the anticoagulant activities of Dextran 40.Approved
Salicylic acidSalicylic acid may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Vet Approved
SalsalateSalsalate may increase the anticoagulant activities of Dextran 40.Approved
SarpogrelateSarpogrelate may increase the anticoagulant activities of Dextran 40.Investigational
SaruplaseSaruplase may increase the anticoagulant activities of Dextran 40.Experimental
SecoisolariciresinolSecoisolariciresinol may decrease the anticoagulant activities of Dextran 40.Investigational
SelexipagSelexipag may increase the anticoagulant activities of Dextran 40.Approved
SemapimodSemapimod may increase the anticoagulant activities of Dextran 40.Investigational
SeratrodastSeratrodast may increase the anticoagulant activities of Dextran 40.Approved
SerrapeptaseSerrapeptase may increase the anticoagulant activities of Dextran 40.Investigational
SevofluraneSevoflurane may increase the anticoagulant activities of Dextran 40.Approved, Vet Approved
SRT501SRT501 may increase the anticoagulant activities of Dextran 40.Investigational
StreptokinaseStreptokinase may increase the anticoagulant activities of Dextran 40.Approved, Investigational
SugammadexSugammadex may increase the anticoagulant activities of Dextran 40.Approved
SulfasalazineSulfasalazine may increase the anticoagulant activities of Dextran 40.Approved
SulindacSulindac may increase the anticoagulant activities of Dextran 40.Approved, Investigational
SulodexideSulodexide may increase the anticoagulant activities of Dextran 40.Approved, Investigational
SuprofenSuprofen may increase the anticoagulant activities of Dextran 40.Approved, Withdrawn
SuxibuzoneSuxibuzone may increase the anticoagulant activities of Dextran 40.Experimental
Synthetic Conjugated Estrogens, ASynthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Dextran 40.Approved
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Dextran 40.Approved
TarenflurbilTarenflurbil may increase the anticoagulant activities of Dextran 40.Investigational
TenecteplaseTenecteplase may increase the anticoagulant activities of Dextran 40.Approved
TenidapTenidap may increase the anticoagulant activities of Dextran 40.Experimental
TenoxicamTenoxicam may increase the anticoagulant activities of Dextran 40.Approved
TepoxalinTepoxalin may increase the anticoagulant activities of Dextran 40.Vet Approved
TeriflunomideTeriflunomide may increase the anticoagulant activities of Dextran 40.Approved
TesmilifeneTesmilifene may increase the anticoagulant activities of Dextran 40.Investigational
Testosterone cypionateThe therapeutic efficacy of Dextran 40 can be increased when used in combination with Testosterone cypionate.Approved
Testosterone enanthateThe therapeutic efficacy of Dextran 40 can be increased when used in combination with Testosterone enanthate.Approved
Testosterone undecanoateThe therapeutic efficacy of Dextran 40 can be increased when used in combination with Testosterone undecanoate.Approved, Investigational
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Dextran 40.Approved
TiboloneTibolone may increase the anticoagulant activities of Dextran 40.Approved, Investigational
TicagrelorTicagrelor may increase the anticoagulant activities of Dextran 40.Approved
TiclopidineTiclopidine may increase the anticoagulant activities of Dextran 40.Approved
TinoridineTinoridine may increase the anticoagulant activities of Dextran 40.Investigational
TinzaparinTinzaparin may increase the anticoagulant activities of Dextran 40.Approved
TioclomarolTioclomarol may increase the anticoagulant activities of Dextran 40.Experimental
TipranavirTipranavir may increase the anticoagulant activities of Dextran 40.Approved, Investigational
TirofibanTirofiban may increase the anticoagulant activities of Dextran 40.Approved
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Dextran 40.Approved, Investigational
TolmetinTolmetin may increase the anticoagulant activities of Dextran 40.Approved
TositumomabThe risk or severity of adverse effects can be increased when Dextran 40 is combined with Tositumomab.Approved, Investigational
TranilastTranilast may increase the anticoagulant activities of Dextran 40.Approved, Investigational
TrapidilTrapidil may increase the anticoagulant activities of Dextran 40.Approved
TreprostinilTreprostinil may increase the anticoagulant activities of Dextran 40.Approved, Investigational
TribenosideTribenoside may increase the anticoagulant activities of Dextran 40.Experimental
TriflusalTriflusal may increase the anticoagulant activities of Dextran 40.Approved, Investigational
TriptolideTriptolide may increase the anticoagulant activities of Dextran 40.Investigational
Trolamine salicylateTrolamine salicylate may increase the anticoagulant activities of Dextran 40.Approved
TroxerutinDextran 40 may increase the anticoagulant activities of Troxerutin.Investigational
UrokinaseUrokinase may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Withdrawn
ValdecoxibValdecoxib may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Withdrawn
Vitamin EVitamin E may increase the anticoagulant activities of Dextran 40.Approved, Nutraceutical, Vet Approved
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Dextran 40.Approved
WarfarinWarfarin may increase the anticoagulant activities of Dextran 40.Approved
XimelagatranXimelagatran may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Withdrawn
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Dextran 40.Approved, Investigational
ZeranolZeranol may decrease the anticoagulant activities of Dextran 40.Vet Approved
ZileutonZileuton may increase the anticoagulant activities of Dextran 40.Approved, Investigational, Withdrawn
ZomepiracZomepirac may increase the anticoagulant activities of Dextran 40.Withdrawn
Food Interactions
Not Available

References

General References
  1. Klotz U, Kroemer H: Clinical pharmacokinetic considerations in the use of plasma expanders. Clin Pharmacokinet. 1987 Feb;12(2):123-35. [PubMed:2435442]
  2. Dailymed [Link]
  3. Drugs.com [Link]
  4. ChemIDplus [Link]
External Links
PubChem Substance
347911127

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2, 3CompletedTreatmentAKI / Liver Cirrhosis1
3Active Not RecruitingTreatmentPhenylketonuria (PKU)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SolutionIntravenous
Injection, solutionIntravenous10 g/100mL
Solution / dropsOphthalmic
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on December 03, 2015 09:51 / Updated on February 03, 2018 16:33