GSK-1292263

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
GSK-1292263
Accession Number
DB12627
Type
Small Molecule
Groups
Investigational
Description

GSK1292263 has been investigated for the treatment of DIABETES MELLITUS, TYPE 2.

Structure
Thumb
Synonyms
Not Available
Categories
Not Available
UNII
R1J57STA6O
CAS number
1032823-75-8
Weight
Average: 456.56
Monoisotopic: 456.183126572
Chemical Formula
C23H28N4O4S
InChI Key
AYJRTVVIBJSSKN-UHFFFAOYSA-N
InChI
InChI=1S/C23H28N4O4S/c1-16(2)22-25-23(31-26-22)27-12-10-17(11-13-27)15-30-19-6-9-21(24-14-19)18-4-7-20(8-5-18)32(3,28)29/h4-9,14,16-17H,10-13,15H2,1-3H3
IUPAC Name
2-(4-methanesulfonylphenyl)-5-({1-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}methoxy)pyridine
SMILES
CC(C)C1=NOC(=N1)N1CCC(COC2=CC=C(N=C2)C2=CC=C(C=C2)S(C)(=O)=O)CC1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
24996872
PubChem Substance
347828838
ChemSpider
25027409
ChEMBL
CHEMBL3187503

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedOtherType 2 Diabetes Mellitus1
2CompletedOtherType 2 Diabetes Mellitus1
2CompletedTreatmentDyslipidemias1
2CompletedTreatmentType 2 Diabetes Mellitus1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0679 mg/mLALOGPS
logP4.02ALOGPS
logP4.11ChemAxon
logS-3.8ALOGPS
pKa (Strongest Acidic)19.69ChemAxon
pKa (Strongest Basic)3.71ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area98.42 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity123.81 m3·mol-1ChemAxon
Polarizability50.72 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Pyridines and derivatives
Sub Class
Phenylpyridines
Direct Parent
Phenylpyridines
Alternative Parents
Benzenesulfonyl compounds / Dialkylarylamines / Alkyl aryl ethers / Piperidines / Sulfones / Heteroaromatic compounds / 1,2,4-oxadiazoles / Oxacyclic compounds / Azacyclic compounds / Organic oxides
show 1 more
Substituents
2-phenylpyridine / Benzenesulfonyl group / Dialkylarylamine / Alkyl aryl ether / Monocyclic benzene moiety / Benzenoid / Piperidine / 1,2,4-oxadiazole / Azole / Heteroaromatic compound
show 15 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 17:19 / Updated on June 04, 2019 07:40