Fluorine F-18

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Fluorine F-18
Accession Number
DB13134
Type
Small Molecule
Groups
Investigational
Description

Fluorine-18 is under investigation in clinical trial NCT00870974 (A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions).

Structure
Thumb
Synonyms
  • Fluorine-18
Categories
UNII
GZ5I74KB8G
CAS number
13981-56-1
Weight
Average: 18.0009
Monoisotopic: 18.000937667
Chemical Formula
F
InChI Key
YCKRFDGAMUMZLT-BJUDXGSMSA-N
InChI
InChI=1S/F/i1-1
IUPAC Name
(18F)fluoranyl
SMILES
[18F]

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
131704324
PubChem Substance
347829252
ChemSpider
21865283
ChEBI
36939
Wikipedia
Fluorine-18

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedDiagnosticBreast Cancer1
0TerminatedDiagnosticDeep Fibromatosis/Desmoid Tumor / Familial Adenomatous Polyposis (FAP)1
1Active Not RecruitingDiagnosticStage I Lung Cancer / Stage I Non-Small Cell Lung Cancer AJCC v7 / Stage IA Non-Small Cell Lung Carcinoma AJCC v7 / Stage IB Non-Small Cell Lung Carcinoma AJCC v7 / Stage II Lung Cancer / Stage II Non-Small Cell Lung Cancer AJCC v7 / Stage IIA Non-Small Cell Lung Carcinoma AJCC v7 / Stage IIB Non-Small Cell Lung Carcinoma AJCC v71
1CompletedNot AvailableAlzheimer's Disease (AD) / Autism Spectrum Conditions/Disorders / Fragile X Syndrome (FXS) / Huntington's Disease (HD) / Mild Cognitive Impairment (MCI) / Parkinson's Disease (PD)1
1RecruitingDiagnosticHormone-Resistant Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer / Metastatic Malignant Neoplasm in the Bone1
1SuspendedTreatmentBreast Adenocarcinoma / Recurrent Breast Carcinoma / Recurrent Hodgkin Lymphoma / Recurrent Mycosis Fungoides / Recurrent Non-Hodgkin Lymphoma / Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma / Refractory Hodgkin Lymphoma / Refractory Nodal Marginal Zone Lymphoma / Refractory Non-Hodgkin's lymphoma / Refractory, advanced Mycosis fungoides / Refractory, primary Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage IV Breast Cancer AJCC v6 and v71
1TerminatedBasic ScienceHealthy Volunteers1
1, 2CompletedDiagnosticHormone Refractory Prostate Cancer / Hormone-Refractory Prostate Cancer1
1, 2CompletedDiagnosticProstate Cancer1
2Active Not RecruitingTreatmentStage III Lung Non-Small Cell Cancer AJCC v7 / Stage IIIA Lung Non-Small Cell Cancer AJCC v7 / Stage IIIB Lung Non-Small Cell Cancer AJCC v71
2CompletedDiagnosticAdult Hepatocellular Carcinoma / Liver Cancer / Localized Resectable Adult Liver Carcinoma1
2RecruitingDiagnosticCigarette Smokers / Current Smokers / Former Smoker / Multiple Pulmonary Nodules / Pulmonary Nodules1
2RecruitingDiagnosticHER2/Neu Negative / Progesterone Receptor Negative / Progesterone Receptor Positive / Stage IV Breast Cancer AJCC v6 and v71
2RecruitingDiagnosticIntracranial Neoplasm / Low Grade Glioma (LGG) / Recurrent Glioblastoma / Recurrent WHO Grade III Glioma / Recurrent World Health Organization (WHO) Grade II Glioma1
Not AvailableActive Not RecruitingDiagnosticEstrogen Receptor Positive / Recurrent Breast Carcinoma / Stage IV Breast Cancer / Stage IV Breast Cancer AJCC v6 and v71
Not AvailableRecruitingDiagnosticMalignant Lymphomas / Recurrent Diffuse Large B-Cell Lymphoma / Refractory Diffuse Large B Cell Lymphoma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0.37ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0.87 m3·mol-1ChemAxon
Polarizability0.44 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as homogeneous halogens. These are inorganic non-metallic compounds in which the largest atom is a nobel gas.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Homogeneous halogens
Sub Class
Not Available
Direct Parent
Homogeneous halogens
Alternative Parents
Not Available
Substituents
Homogeneous halogen
Molecular Framework
Not Available
External Descriptors
fluorine atom (CHEBI:36939)

Drug created on October 20, 2016 21:34 / Updated on June 12, 2020 10:53

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