Parsaclisib

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Logo pink
Are you a
new drug developer?
Contact us to learn more about our customized products and solutions.
Name
Parsaclisib
Accession Number
DB14867
Type
Small Molecule
Groups
Investigational
Description

Parsaclisib is under investigation in clinical trial NCT03126019 (An Open-Label Study of Parsaclisib in Relapsed or Refractory Follicular Lymphoma (CITADEL-203)).

Structure
Thumb
Synonyms
  • INCB050465
Categories
Not Available
UNII
OS7097575K
CAS number
1426698-88-5
Weight
Average: 432.88
Monoisotopic: 432.1476798
Chemical Formula
C20H22ClFN6O2
InChI Key
ZQPDJCIXJHUERQ-QWRGUYRKSA-N
InChI
InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11-/m0/s1
IUPAC Name
SMILES
CCOC1=C(C=C(Cl)C(F)=C1[C@@H]1CNC(=O)C1)[C@H](C)N1N=C(C)C2=C1N=CN=C2N

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
64835232
BindingDB
272573

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentAdvanced Solid Tumors / Tumors, Solid1
1Active Not RecruitingTreatmentMalignant Lymphomas / NHL - Non-Hodgkin's Lymphoma / Relapsed or Refractory Follicular Lymphoma1
1RecruitingTreatmentAdvanced Solid Tumors / Cancer, Breast / Colorectal Cancer (CRC) / CRC (Colorectal Cancer) / Endometrial Cancers / Head and Neck Carcinoma / Head and Neck Squamous Cell Carcinoma (HNSCC) / Lung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancer Small Cell Lung Cancer (SCLC) / Lung Cancers / Malignant Neoplasm of Pancreas / Melanoma / Microsatellite Unstable (MSI) Colorectal Cancer / MMR-deficient Tumors / Pancreatic Ductal Adenocarcinoma / RCC (Renal Cell Carinoma) / Renal Cell Adenocarcinoma / SCCHN (Head and Neck Squamous Cell Carcinoma) / Transitional Cell Carcinoma of the Genitourinary Tract / Triple Negative Breast Cancer (TNBC) / Tumors, Solid / UC (Urothelial Cancer)1
1RecruitingTreatmentLymphoma, B-Cell1
1RecruitingTreatmentLymphoma, B-Cell / Malignant Lymphomas1
1RecruitingTreatmentRefractory Diffuse Large B Cell Lymphoma / Relapsed, Diffuse Large B-cell Lymphoma1
1RecruitingTreatmentUnresectable or Metastatic Solid Tumors1
1, 2Active Not RecruitingTreatmentAdvanced Malignancies / Cancer, Advanced / Metastatic Cancers / Tumors, Solid1
1, 2Active Not RecruitingTreatmentB-Cell Malignancies1
2Active Not RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL) / Malignant Lymphomas / NHL (Non-Hodgkin Lymphoma)1
2RecruitingTreatmentAgnogenic Myeloid Metaplasia / MPN (Myeloproliferative Neoplasms)1
2RecruitingTreatmentAutoimmune Hemolytic Anemia1
2RecruitingTreatmentFollicular Lymphoma (FL) / Malignant Lymphomas / NHL - Non-Hodgkin's Lymphoma1
2RecruitingTreatmentMalignant Lymphomas / Mantle Cell Lymphoma (MCL) / NHL - Non-Hodgkin's Lymphoma1
2RecruitingTreatmentMalignant Lymphomas / NHL (Non-Hodgkin Lymphoma) / Refractory Marginal Zone Lymphoma / Relapsed Marginal Zone Lymphoma1
2RecruitingTreatmentPrimary Sjögren's Syndrome1
2WithdrawnTreatmentPemphigus Vulgaris (PV)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 20, 2019 08:31 / Updated on May 21, 2019 12:30