Pittsburgh Compound B

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Pittsburgh Compound B
Accession Number
DB15161
Type
Small Molecule
Groups
Investigational
Description

Pittsburgh Compound B is under investigation in clinical trial NCT01723553 (Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD).

Structure
Thumb
Synonyms
  • (N-methyl-(11C))2-(4'-methylaminophenyl)-6-hydroxybenzothiazole
  • 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • C-11 PiB
Categories
UNII
7P55415B0R
CAS number
566170-04-5
Weight
Average: 255.32
Monoisotopic: 255.078468006
Chemical Formula
C14H12N2OS
InChI Key
ZQAQXZBSGZUUNL-BJUDXGSMSA-N
InChI
InChI=1S/C14H12N2OS/c1-15-10-4-2-9(3-5-10)14-16-12-7-6-11(17)8-13(12)18-14/h2-8,15,17H,1H3/i1-1
IUPAC Name
2-{4-[(11C)methylamino]phenyl}-1,3-benzothiazol-6-ol
SMILES
[11CH3]NC1=CC=C(C=C1)C1=NC2=C(S1)C=C(O)C=C2

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
2104829
ChEMBL
CHEMBL207456

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedBasic ScienceAlcohol Use Disorder (AUD)1
0Enrolling by InvitationDiagnosticAlzheimer's Disease (AD)1
1CompletedBasic ScienceAlzheimer's Disease (AD)1
1CompletedDiagnosticAlzheimer's Disease (AD)1
1CompletedDiagnosticAphasia / Aphasia, Non-fluent / Apraxia of Speech / PPA / Primary Progressive Nonfluent Aphasia / Progressive Aphasia / Progressive Primary Aphasia / Semantic Dementia1
1CompletedDiagnosticAtypical Alzheimers Disease / Logopenic Variant of Primary Progressive Aphasia (LPA) / Posterior Cortical Atrophy (PCA)1
2Active Not RecruitingDiagnosticAlzheimer's Disease (AD)1
2CompletedBasic ScienceAlzheimer's Disease (AD)1
2CompletedDiagnosticAlzheimer's Disease (AD)1
4Enrolling by InvitationDiagnosticAlzheimer's Disease (AD) / Dementia, Vascular / Diffuse Lewy Body Disease / Frontotemporal Dementia1
4Enrolling by InvitationDiagnosticDiffuse Lewy Body Disease1
Not AvailableRecruitingDiagnosticAtypical Alzheimer's Disease / Logopenic Progressive Aphasia (LPA) / Posterior Cortical Atrophy (PCA)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0162 mg/mLALOGPS
logP4.11ALOGPS
logP3.31ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)9.23ChemAxon
pKa (Strongest Basic)3.65ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area45.15 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity84.4 m3·mol-1ChemAxon
Polarizability28.12 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 20, 2019 08:55 / Updated on June 12, 2020 10:53

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