NAV

HSK-3486

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
HSK-3486
DrugBank Accession Number
DB16295
Background

HSK-3486 is under investigation in clinical trial NCT04620031 (A Study Evaluating Sedation of Intravenous Administration of HSK3486 Injectable Emulsion in ICU Patients Undergoing Mechanical Ventilation).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 204.313
Monoisotopic: 204.151415264
Chemical Formula
C14H20O
Synonyms
Not Available
External IDs
  • HSK-3486
  • HSK-3486, (R)-
  • HSK3486
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
M3WGS532VY
CAS number
1637741-58-2
InChI Key
BMEARIQHWSVDBS-SNVBAGLBSA-N
InChI
InChI=1S/C14H20O/c1-9(2)12-5-4-6-13(14(12)15)10(3)11-7-8-11/h4-6,9-11,15H,7-8H2,1-3H3/t10-/m1/s1
IUPAC Name
2-[(1R)-1-cyclopropylethyl]-6-(propan-2-yl)phenol
SMILES
CC(C)C1=CC=CC([C@H](C)C2CC2)=C1O

References

General References
Not Available
ChemSpider
76794458
ChEMBL
CHEMBL4094894

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentAnesthesia therapy1
3CompletedTreatmentGeneral Anesthesia1
3CompletedTreatmentInduction and Maintenance of General Anesthesia1
3CompletedTreatmentInduction of anesthesia therapy1
3CompletedTreatmentSedation in Intensive Care Unit Patients1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0346 mg/mLALOGPS
logP4.53ALOGPS
logP4.43Chemaxon
logS-3.8ALOGPS
pKa (Strongest Acidic)10.95Chemaxon
pKa (Strongest Basic)-5Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count1Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area20.23 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity63.77 m3·mol-1Chemaxon
Polarizability24.64 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0090000000-83c69b2220bd3f5d8a78
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-066r-9230000000-a0884098b4c5ffd32c92
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0190000000-2083479ed0eb91c1e724
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-066r-9740000000-980b590f6aa78f8c70ef
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0uxr-3910000000-02f668191895d8f7869e
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-014i-5900000000-16e9a59a1dd7ba60761e
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at December 15, 2020 18:18 / Updated at December 20, 2020 03:40