NAV

ZM-39923

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
ZM-39923
DrugBank Accession Number
DB17064
Background

ZM-39923 is a small molecule that inhibits Janus kinase and human tissue transglutaminase (TGM2).1

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 331.459
Monoisotopic: 331.193614429
Chemical Formula
C23H25NO
Synonyms
  • 1-propanone, 3-((1-methylethyl)(phenylmethyl)amino)-1-(2-naphthalenyl)-
  • 3-((1-methylethyl)(phenylmethyl)amino)-1-(2-naphthalenyl)-1-propanone
  • 3-(benzyl(propan-2-yl)amino)-1-(naphthalen-2-yl)propan-1-one
  • Jak3 inhibitor iv
External IDs
  • ZM-39923
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
ZM-39923 hydrochlorideNot Available1021868-92-7Not applicable

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
M0ZX82000S
CAS number
273727-89-2
InChI Key
JSASWRWALCMOQP-UHFFFAOYSA-N
InChI
InChI=1S/C23H25NO/c1-18(2)24(17-19-8-4-3-5-9-19)15-14-23(25)22-13-12-20-10-6-7-11-21(20)16-22/h3-13,16,18H,14-15,17H2,1-2H3
IUPAC Name
3-[benzyl(propan-2-yl)amino]-1-(naphthalen-2-yl)propan-1-one
SMILES
CC(C)N(CCC(=O)C1=CC2=C(C=CC=C2)C=C1)CC1=CC=CC=C1

References

General References
  1. Lai TS, Liu Y, Tucker T, Daniel KR, Sane DC, Toone E, Burke JR, Strittmatter WJ, Greenberg CS: Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22;15(9):969-78. doi: 10.1016/j.chembiol.2008.07.015. [Article]
ChemSpider
3665
BindingDB
81346
ChEBI
92715
ChEMBL
CHEMBL596674
ZINC
ZINC000001487934

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000864 mg/mLALOGPS
logP4.83ALOGPS
logP5.15Chemaxon
logS-5.6ALOGPS
pKa (Strongest Acidic)16.16Chemaxon
pKa (Strongest Basic)8.78Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area20.31 Å2Chemaxon
Rotatable Bond Count7Chemaxon
Refractivity104.82 m3·mol-1Chemaxon
Polarizability39.01 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at October 11, 2022 19:29 / Updated at December 13, 2022 10:46