NAV

BMS-986278

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
BMS-986278
DrugBank Accession Number
DB18011
Background

Not Available

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 445.52
Monoisotopic: 445.232519118
Chemical Formula
C22H31N5O5
Synonyms
  • (1s,3s)-3-((2-methyl-6-(1-methyl-5-(((methyl(propyl)carbamoyl)oxy)methyl)-1h-1,2,3-triazol-4-yl)pyridin-3-yl)oxy)cyclohexane-1-carboxylic acid
  • Cyclohexanecarboxylic acid, 3-((2-methyl-6-(1-methyl-5-((((methylpropylamino)carbonyl)oxy)methyl)-1h-1,2,3-triazol-4-yl)-3-pyridinyl)oxy)-, (1s,3s)-
External IDs
  • BMS 986278
  • BMS-986278
  • BMS986278
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Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
4UN9AOU6G8
CAS number
2170126-74-4
InChI Key
UEUNDURNLYLSNB-HOTGVXAUSA-N
InChI
InChI=1S/C22H31N5O5/c1-5-11-26(3)22(30)31-13-18-20(24-25-27(18)4)17-9-10-19(14(2)23-17)32-16-8-6-7-15(12-16)21(28)29/h9-10,15-16H,5-8,11-13H2,1-4H3,(H,28,29)/t15-,16-/m0/s1
IUPAC Name
(1S,3S)-3-({2-methyl-6-[1-methyl-5-({[methyl(propyl)carbamoyl]oxy}methyl)-1H-1,2,3-triazol-4-yl]pyridin-3-yl}oxy)cyclohexane-1-carboxylic acid
SMILES
CCCN(C)C(=O)OCC1=C(N=NN1C)C1=CC=C(O[C@H]2CCC[C@@H](C2)C(O)=O)C(C)=N1

References

General References
Not Available
ChemSpider
115009679
ChEMBL
CHEMBL5087506

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3RecruitingTreatmentIdiopathic Pulmonary Fibrosis (IPF)1
3RecruitingTreatmentProgressive Pulmonary Fibrosis1
2CompletedTreatmentPulmonary Fibrosis1
1CompletedTreatmentHealthy Volunteers (HV)8
1CompletedTreatmentIdiopathic Pulmonary Fibrosis (IPF)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP2.48Chemaxon
pKa (Strongest Acidic)4.31Chemaxon
pKa (Strongest Basic)3.26Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count7Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area119.67 Å2Chemaxon
Rotatable Bond Count9Chemaxon
Refractivity127.45 m3·mol-1Chemaxon
Polarizability47.33 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at September 06, 2023 21:02 / Updated at September 07, 2023 18:09