PF-07059013
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- PF-07059013
- DrugBank Accession Number
- DB18122
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 365.368
Monoisotopic: 365.128802938 - Chemical Formula
- C19H16FN5O2
- Synonyms
- 2(1h)-pyridinone, 6-((1s)-1-((2-amino-6-fluoro-3-quinolinyl)oxy)ethyl)-5-(1h-pyrazol-1-yl)-
- 6-((1s)-1-((2-amino-6-fluoroquinolin-3-yl)oxy)ethyl)-5-(1h-pyrazol-1-yl)pyridin-2(1h)-one
- External IDs
- PF-07059013
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- FXK42BP3GL
- CAS number
- 2435610-93-6
- InChI Key
- CLEFVPILGAPOTG-NSHDSACASA-N
- InChI
- InChI=1S/C19H16FN5O2/c1-11(18-15(5-6-17(26)24-18)25-8-2-7-22-25)27-16-10-12-9-13(20)3-4-14(12)23-19(16)21/h2-11H,1H3,(H2,21,23)(H,24,26)/t11-/m0/s1
- IUPAC Name
- 6-[(1S)-1-[(2-amino-6-fluoroquinolin-3-yl)oxy]ethyl]-5-(1H-pyrazol-1-yl)-1,2-dihydropyridin-2-one
- SMILES
- C[C@H](OC1=CC2=CC(F)=CC=C2N=C1N)C1=C(C=CC(=O)N1)N1C=CC=N1
References
- General References
- Not Available
- External Links
- ChemSpider
- 115040920
- ChEMBL
- CHEMBL4650304
- PDBe Ligand
- VUD
- PDB Entries
- 7jy3
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Terminated Basic Science Healthy Volunteers (HV) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 1.98 Chemaxon pKa (Strongest Acidic) 10.07 Chemaxon pKa (Strongest Basic) 5.16 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 95.06 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 111.83 m3·mol-1 Chemaxon Polarizability 36.14 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at September 12, 2023 16:55 / Updated at September 12, 2023 18:34