Severe or persistent diarrhea

Also known as: Diarrhea / Diarrhoea / Diarrhea NOS / Diarrhoea NOS

DrugDrug NameDrug Description
DB01294Bismuth subsalicylateBismuth subsalicylate is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. It is also the main ingredient of Kaopectate. It displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic.
DB01501DifenoxinDifenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a brand mixture which combines atropine sulfate and difenoxin hydrochloride. It is approved by the FDA to treat acute and chronic diarrhea. Difenoxin is an active metabolite of the anti-diarrheal drug, diphenoxylate, which is also used in combination with atropine in the brand mixture Lomotil(R). It works mostly in the periphery and activates opioid receptors in the intestine rather than the central nervous system (CNS). [3] Difenoxin is also closely related to loperamide, but unlike loperamide it is still capable of crossing the blood brain barrier to produce weak sedative and analgesic effects. However, the antidiarrheal potency of difenoxin is much greater than its CNS effects, which makes it an attractive alternative to other opioids.
DB01081DiphenoxylateA meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medication is classified as a Schedule V under the Controlled Substances Act by the Food and Drug Administration (FDA) and the DEA in the United States when used in preparations. When diphenoxylate is used alone, it is classified as a Schedule II.
DB00836LoperamideOne of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
DB00085PancrelipasePancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands.[L2509] The pancrelipase mixture was developed by Ortho-McNeil-Janssen Pharmaceuticals, Inc and FDA approved on April 12, 2010.[L2510] For further information on the components of this mixture please visit [DB11065], [DB11066] and [DB13147].
DB09449Sodium phosphate, monobasicSodium phosphate is a saline laxative that is thought to work by increasing fluid in the small intestine. It usually results in a bowel movement after 30 minutes to 6 hours.
DrugDrug NamePhaseStatusCount
DB00065Infliximab0Not Yet Recruiting1
DB00635Prednisone0Not Yet Recruiting1
DB14646Prednisone acetate0Not Yet Recruiting1
DB09033Vedolizumab0Not Yet Recruiting1
DB00671Cefixime1Completed1
DB01416Cefpodoxime1Completed1
DB00482Celecoxib1Completed1
DB13011Diethylhomospermine1Completed1
DB00544Fluorouracil1Completed1
DB12959IOWH-0321Completed1
DB00762Irinotecan1Completed3
DB00650Leucovorin1Completed1
DB00526Oxaliplatin1Completed1
DB11696Racecadotril1Completed1
DB00853Temozolomide1Completed1
DB01593Zinc1Completed1
DB01222Budesonide2Terminated1
DB06772Cabazitaxel2Terminated1
DB01394Colchicine2Recruiting1
DB00930Colesevelam2Completed1
DB04941Crofelemer2Completed1
DB00531Cyclophosphamide2Completed1
DB06336Elsiglutide2Completed1
DB09272Eluxadoline2Not Yet Recruiting1
DB08874Fidaxomicin2Completed1
DB00099Filgrastim2Completed1
DB00544Fluorouracil2Terminated1
DB00762Irinotecan2Terminated1
DB00650Leucovorin2Terminated1
DB00104Octreotide2Terminated1
DB00635Prednisone2Terminated1
DB01220Rifaximin2Completed1
DB10276Rotavirus Vaccine2Completed1
DB12076Surotomycin2Completed1
DB00512Vancomycin2Completed1
DB06361rsPSMA Vaccine2Completed1
DB06361rsPSMA Vaccine2Terminated1
DB01222Budesonide2 / 3Terminated1
DB06791Lanreotide2 / 3Completed1
DB00244Mesalazine2 / 3Completed1
DB00916Metronidazole2 / 3Unknown Status1
DB01220Rifaximin2 / 3Completed1
DB10276Rotavirus Vaccine2 / 3Completed1
DB10276Rotavirus Vaccine2 / 3Recruiting1
DB00207Azithromycin3Completed1
DB00207Azithromycin3Recruiting1
DB01373Calcium3Terminated1
DB06724Calcium Carbonate3Terminated1
DB04941Crofelemer3Completed1
DB08874Fidaxomicin3Completed2
DB00762Irinotecan3Terminated1
DB00709Lamivudine3Terminated1
DB01137Levofloxacin3Completed1
DB00836Loperamide3Completed2
DB00836Loperamide3Terminated2
DB12583Maltodextrin3Recruiting1
DB00220Nelfinavir3Terminated1
DB00507Nitazoxanide3Completed1
DB00104Octreotide3Completed2
DB00104Octreotide3Terminated1
DB00904Ondansetron3Not Yet Recruiting1
DB00686Pentosan Polysulfate3Completed1
DB11696Racecadotril3Completed1
DB01220Rifaximin3Completed4
DB10303Rotavirus Vaccine3Completed1
DB00795Sulfasalazine3Active Not Recruiting1
DB01344Tolevamer3Terminated1
DB00512Vancomycin3Completed2
DB00495Zidovudine3Terminated1
DB01593Zinc3Completed1
DB11248Zinc gluconate3Completed1
DB00518Albendazole4Withdrawn1
DB00207Azithromycin4Completed1
DB00207Azithromycin4Not Yet Recruiting1
DB00207Azithromycin4Recruiting1
DB01212Ceftriaxone4Unknown Status1
DB00537Ciprofloxacin4Not Yet Recruiting1
DB00836Loperamide4Completed3
DB13654Montmorillonite4Completed1
DB00104Octreotide4Completed1
DB00904Ondansetron4Completed2
DB10303Rotavirus Vaccine4Active Not Recruiting1
DB10276Rotavirus Vaccine4Recruiting1
DB01586Ursodeoxycholic acid4Recruiting1
DB00512Vancomycin4Enrolling by Invitation1
DB09145Water4Enrolling by Invitation1
DB01593Zinc4Completed1
DB01294Bismuth subsalicylateNot AvailableCompleted1
DB08874FidaxomicinNot AvailableCompleted1
DB00916MetronidazoleNot AvailableCompleted1
DB00507NitazoxanideNot AvailableCompleted1
DB00104OctreotideNot AvailableCompleted2
DB00104OctreotideNot AvailableNot Yet Recruiting1
DB11058PetrolatumNot AvailableCompleted1
DB00560TigecyclineNot AvailableCompleted1
DB00512VancomycinNot AvailableCompleted1
DB00162Vitamin ANot AvailableCompleted1
DB01593ZincNot AvailableCompleted4
DB09322Zinc sulfateNot AvailableCompleted2