ERBB2 Gene Mutation

Drug	Drug Name	Drug Description
DB14962	Trastuzumab deruxtecan	An antibody used to treat certain types of unresectable or metastatic HER2 positive breast cancer.

Drug	Drug Name	Target	Type
DB14962	Trastuzumab deruxtecan	P-glycoprotein 1	transporter
DB14962	Trastuzumab deruxtecan	High affinity immunoglobulin gamma Fc receptor I	target
DB14962	Trastuzumab deruxtecan	DNA topoisomerase 1	target
DB14962	Trastuzumab deruxtecan	Lysosomal alpha-glucosidase	enzyme
DB14962	Trastuzumab deruxtecan	DNA topoisomerase 1	enzyme
DB14962	Trastuzumab deruxtecan	Cathepsin B	enzyme
DB14962	Trastuzumab deruxtecan	Cathepsin L1	enzyme
DB14962	Trastuzumab deruxtecan	Cytochrome P450 3A4	enzyme
DB14962	Trastuzumab deruxtecan	Solute carrier organic anion transporter family member 1B1	transporter
DB14962	Trastuzumab deruxtecan	Solute carrier organic anion transporter family member 1B3	transporter
DB14962	Trastuzumab deruxtecan	Multidrug and toxin extrusion protein 2	transporter
DB14962	Trastuzumab deruxtecan	Multidrug resistance-associated protein 1	transporter
DB14962	Trastuzumab deruxtecan	ATP-binding cassette sub-family G member 2	transporter

Drug	Drug Name	Phase	Status	Count
DB01590	Everolimus	1	Active Not Recruiting	1
DB11828	Neratinib	1	Active Not Recruiting	1
DB09073	Palbociclib	1	Active Not Recruiting	1
DB08911	Trametinib	1	Active Not Recruiting	1
DB12114	Poziotinib	2	Active Not Recruiting	1