Aldo-keto reductase family 1 member B15

Details

Name
Aldo-keto reductase family 1 member B15
Synonyms
  • 1.1.1.-
  • Estradiol 17-beta-dehydrogenase AKR1B15
  • Farnesol dehydrogenase
  • Testosterone 17beta-dehydrogenase
Gene Name
AKR1B15
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052191|Aldo-keto reductase family 1 member B15
MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQ
EKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD
DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD
FKEFSHLEDFPFDAEY
Number of residues
316
Molecular Weight
36536.795
Theoretical pI
Not Available
GO Classification
Functions
alcohol dehydrogenase (NADP+) activity / alditol / allyl-alcohol dehydrogenase activity / estradiol 17-beta-dehydrogenase activity / farnesol dehydrogenase activity / NADP-retinol dehydrogenase activity / oxidoreductase activity / oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor / testosterone 17-beta-dehydrogenase (NADP+) activity
Processes
estrogen biosynthetic process
Components
cytosol / mitochondrial matrix / mitochondrion
General Function
Isoform 1 Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:26222439, PubMed:21276782). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439).
Specific Function
Alcohol dehydrogenase (nadp+) activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Mitochondrion
Gene sequence
>lcl|BSEQ0052192|Aldo-keto reductase family 1 member B15 (AKR1B15)
ATGGTCTTACAAATGGAACCCCAAGTGAACTCAACTAACAACTTCCACCAAGGACCCCTG
GACCAACCCGTTGGCCCTTTGACTGGCCTAAAGAGTTCCCTTCTGAAGGACACTACAAGT
GCAGGGCCCCTTCTTCGCCCCTATCCAGCATCTCTTCTCGGCAAAGTGAAAGAAGCGGTG
AAGGTGGCCATTGATGCAGAATATCGCCACATTGACTGTGCCTATTTCTATGAGAATCAA
CATGAGGTGGGAGAAGCCATCCAAGAGAAGATCCAAGAGAAGGCTGTGATGCGGGAGGAC
CTGTTCATCGTCAGCAAGGTGTGGCCCACTTTCTTTGAGAGACCCCTTGTGAGGAAAGCC
TTTGAGAAGACCCTCAAGGACCTGAAGCTGAGCTATCTGGACGTCTATCTTATTCACTGG
CCACAGGGATTCAAGACTGGGGATGACTTTTTCCCCAAAGATGATAAAGGTAATATGATC
AGTGGAAAAGGAACGTTCTTGGATGCCTGGGAGGCCATGGAGGAGCTGGTGGACGAGGGG
CTGGTGAAAGCCCTTGGGGTCTCAAATTTCAACCACTTCCAGATCGAGAGGCTCTTGAAC
AAACCTGGACTGAAATATAAACCAGTGACTAACCAGGTTGAGTGTCACCCATACCTCACG
CAGGAGAAACTGATCCAGTACTGCCACTCCAAGGGCATCACCGTTACGGCCTACAGCCCC
CTGGGCTCTCCGGATAGACCTTGGGCCAAACCTGAGGACCCTTCCCTGCTGGAGGATCCC
AAGATTAAGGAGATTGCTGCAAAGCACAAAAAAACCACAGCCCAGGTTCTGATCCGTTTC
CATATCCAGAGGAATGTGACAGTGATCCCCAAGTCTATGACACCAGCACACATTGTTGAG
AACATTCAGGTCTTTGACTTTAAATTGAGTGATGAGGAGATGGCAACCATACTCAGCTTC
AACAGAAACTGGAGGGCCTTTGACTTCAAGGAATTCTCTCATTTGGAGGACTTTCCCTTC
GATGCAGAATATTGA
Chromosome Location
7
Locus
7q33
External Identifiers
ResourceLink
UniProtKB IDC9JRZ8
UniProtKB Entry NameAK1BF_HUMAN
HGNC IDHGNC:37281
General References
  1. Salabei JK, Li XP, Petrash JM, Bhatnagar A, Barski OA: Functional expression of novel human and murine AKR1B genes. Chem Biol Interact. 2011 May 30;191(1-3):177-84. doi: 10.1016/j.cbi.2011.01.020. Epub 2011 Jan 27. [Article]
  2. Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK: The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-64. [Article]
  3. Weber S, Salabei JK, Moller G, Kremmer E, Bhatnagar A, Adamski J, Barski OA: Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates. J Biol Chem. 2015 Mar 6;290(10):6531-45. doi: 10.1074/jbc.M114.610121. Epub 2015 Jan 10. [Article]
  4. Gimenez-Dejoz J, Kolar MH, Ruiz FX, Crespo I, Cousido-Siah A, Podjarny A, Barski OA, Fanfrlik J, Pares X, Farres J, Porte S: Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase. PLoS One. 2015 Jul 29;10(7):e0134506. doi: 10.1371/journal.pone.0134506. eCollection 2015. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB06077Lumateperoneapproved, investigationalnosubstrateDetails