Aklanonic acid methyl ester cyclase AcmA

Details

Name
Aklanonic acid methyl ester cyclase AcmA
Synonyms
  • 5.5.1.23
  • AAME cyclase
  • aknH
  • Methyl aklanonate cyclase
Gene Name
acma
Organism
Streptomyces galilaeus
Amino acid sequence
>lcl|BSEQ0022075|Aklanonic acid methyl ester cyclase AcmA
MSEQIAAVRRMVEAYNTGKTDDVADYIHPEYMNPGTLEFTSLRGPELFAINVAWVKKTFS
EEARLEEVGIEERADWVRARLVLYGRHVGEMVGMAPTGRLFSGEQIHLLHFVDGKIHHHR
DWPDYQGTYRQLGEPWPETEHRRP
Number of residues
144
Molecular Weight
16730.765
Theoretical pI
6.08
GO Classification
Functions
intramolecular lyase activity
Processes
antibiotic biosynthetic process / daunorubicin biosynthetic process / doxorubicin metabolic process
General Function
Not Available
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0006516|435 bp
GTGAGTGAGCAGATAGCGGCCGTTCGGCGCATGGTCGAGGCGTACAACACCGGAAAAACG
GATGATGTGGCCGACTACATCCATCCGGAATACATGAATCCGGGAACCCTGGAATTCACC
TCGCTGCGTGGCCCGGAACTCTTCGCGATCAATGTCGCGTGGGTCAAGAAGACGTTCTCC
GAGGAGGCGCGGCTGGAAGAGGTCGGCATCGAGGAGCGGGCCGACTGGGTGCGCGCCCGG
CTGGTGCTCTACGGCCGGCACGTCGGTGAGATGGTCGGCATGGCGCCGACCGGACGGCTG
TTCTCCGGCGAGCAGATCCATCTCCTGCACTTCGTCGACGGGAAGATCCACCACCACCGC
GACTGGCCCGACTACCAGGGCACCTACCGCCAGCTCGGCGAGCCGTGGCCGGAGACCGAG
CACCGCCGTCCCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDO52646
UniProtKB Entry NameDNRD_STRGJ
GenBank Gene IDAF043550
General References
  1. Kantola J, Kunnari T, Hautala A, Hakala J, Ylihonko K, Mantsala P: Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp. Microbiology. 2000 Jan;146 ( Pt 1):155-63. [Article]
  2. Raty K, Kantola J, Hautala A, Hakala J, Ylihonko K, Mantsala P: Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster. Gene. 2002 Jun 26;293(1-2):115-22. [Article]
  3. Chung JY, Fujii I, Harada S, Sankawa U, Ebizuka Y: Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus. J Bacteriol. 2002 Nov;184(22):6115-22. [Article]
  4. Kallio P, Sultana A, Niemi J, Mantsala P, Schneider G: Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity. J Mol Biol. 2006 Mar 17;357(1):210-20. Epub 2006 Jan 6. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04624DERIVATIVE OF AKLANONIC ACID METHYL ESTER (AAME)experimentalunknownDetails