Growth/differentiation factor 11
Details
- Name
- Growth/differentiation factor 11
- Synonyms
- BMP-11
- BMP11
- Bone morphogenetic protein 11
- GDF-11
- Gene Name
- GDF11
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0053856|Growth/differentiation factor 11 MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
- Number of residues
- 407
- Molecular Weight
- 45090.36
- Theoretical pI
- Not Available
- GO Classification
- Functionscytokine activity / growth factor activityProcessesamacrine cell differentiation / camera-type eye morphogenesis / cell population proliferation / mesoderm development / metanephros development / negative regulation of amacrine cell differentiation / negative regulation of cell population proliferation / nervous system development / positive regulation of pathway-restricted SMAD protein phosphorylation / roof of mouth development / skeletal system development / SMAD protein signal transduction / spinal cord anterior/posterior patterning / type B pancreatic cell maturation / ureteric bud developmentComponentsextracellular space / intracellular membrane-bounded organelle / nucleoplasm / protein-containing complex
- General Function
- Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning and orofacial development (PubMed:31215115). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634).
- Specific Function
- Cytokine activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0053857|Growth/differentiation factor 11 (GDF11) ATGGTGCTCGCGGCCCCGCTGCTGCTGGGCTTCCTGCTCCTCGCCCTGGAGCTGCGGCCC CGGGGGGAGGCGGCCGAGGGCCCCGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCAGCG GCGGGGGTCGGGGGGGAGCGCTCCAGCCGGCCAGCCCCGTCCGTGGCGCCCGAGCCGGAC GGCTGCCCCGTGTGCGTTTGGCGGCAGCACAGCCGCGAGCTGCGCCTAGAGAGCATCAAG TCGCAGATCTTGAGCAAACTGCGGCTCAAGGAGGCGCCCAACATCAGCCGCGAGGTGGTG AAGCAGCTGCTGCCCAAGGCGCCGCCGCTGCAGCAGATCCTGGACCTACACGACTTCCAG GGCGACGCGCTGCAGCCCGAGGACTTCCTGGAGGAGGACGAGTACCACGCCACCACCGAG ACCGTCATTAGCATGGCCCAGGAGACGGACCCAGCAGTACAGACAGATGGCAGCCCTCTC TGCTGCCATTTTCACTTCAGCCCCAAGGTGATGTTCACAAAGGTACTGAAGGCCCAGCTG TGGGTGTACCTACGGCCTGTACCCCGCCCAGCCACAGTCTACCTGCAGATCTTGCGACTA AAACCCCTAACTGGGGAAGGGACCGCAGGGGGAGGGGGCGGAGGCCGGCGTCACATCCGT ATCCGCTCACTGAAGATTGAGCTGCACTCACGCTCAGGCCATTGGCAGAGCATCGACTTC AAGCAAGTGCTACACAGCTGGTTCCGCCAGCCACAGAGCAACTGGGGCATCGAGATCAAC GCCTTTGATCCCAGTGGCACAGACCTGGCTGTCACCTCCCTGGGGCCGGGAGCCGAGGGG CTGCATCCATTCATGGAGCTTCGAGTCCTAGAGAACACAAAACGTTCCCGGCGGAACCTG GGTCTGGACTGCGACGAGCACTCAAGCGAGTCCCGCTGCTGCCGATATCCCCTCACAGTG GACTTTGAGGCTTTCGGCTGGGACTGGATCATCGCACCTAAGCGCTACAAGGCCAACTAC TGCTCCGGCCAGTGCGAGTACATGTTCATGCAAAAATATCCGCATACCCATTTGGTGCAG CAGGCCAATCCAAGAGGCTCTGCTGGGCCCTGTTGTACCCCCACCAAGATGTCCCCAATC AACATGCTCTACTTCAATGACAAGCAGCAGATTATCTACGGCAAGATCCCTGGCATGGTG GTGGATCGCTGTGGCTGCTCTTAA
- Chromosome Location
- 12
- Locus
- 12q13.2
- External Identifiers
Resource Link UniProtKB ID O95390 UniProtKB Entry Name GDF11_HUMAN HGNC ID HGNC:4216 - General References
- Not Available