Thioredoxin domain-containing protein 12
Details
- Name
- Thioredoxin domain-containing protein 12
- Synonyms
- 1.8.4.2
- Endoplasmic reticulum resident protein 18
- Endoplasmic reticulum resident protein 19
- ER protein 18
- ER protein 19
- ERp18
- ERp19
- hTLP19
- Thioredoxin-like protein p19
- TLP19
- Gene Name
- TXNDC12
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0019261|Thioredoxin domain-containing protein 12 METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVI IHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDP SGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL
- Number of residues
- 172
- Molecular Weight
- 19205.615
- Theoretical pI
- 5.1
- GO Classification
- Functionspeptide disulfide oxidoreductase activity / protein-disulfide reductase (glutathione) activityProcessescell redox homeostasis / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayComponentsendoplasmic reticulum lumen
- General Function
- Protein-disulfide reductase (glutathione) activity
- Specific Function
- Possesses significant protein thiol-disulfide oxidase activity.
- Pfam Domain Function
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum lumen
- Gene sequence
>lcl|BSEQ0019262|Thioredoxin domain-containing protein 12 (TXNDC12) ATGGAGACGCGGCCTCGTCTCGGGGCCACCTGTTTGCTGGGCTTCAGTTTCCTGCTCCTC GTCATCTCTTCTGATGGACATAATGGGCTTGGAAAGGGTTTTGGAGATCATATTCATTGG AGGACACTGGAAGATGGGAAGAAAGAAGCAGCTGCCAGTGGACTGCCCCTGATGGTGATT ATTCATAAATCCTGGTGTGGAGCTTGCAAAGCTCTAAAGCCCAAATTTGCAGAATCTACG GAAATTTCAGAACTCTCCCATAATTTTGTTATGGTAAATCTTGAGGATGAAGAGGAACCC AAAGATGAAGATTTCAGCCCTGACGGGGGTTATATTCCACGAATCCTTTTTCTGGATCCC AGTGGCAAGGTGCATCCTGAAATCATCAATGAGAATGGAAACCCCAGCTACAAGTATTTT TATGTCAGTGCCGAGCAAGTTGTTCAGGGGATGAAGGAAGCTCAGGAAAGGCTGACGGGT GATGCCTTCAGAAAGAAACATCTTGAAGATGAATTGTAA
- Chromosome Location
- 1
- Locus
- 1p32.3
- External Identifiers
Resource Link UniProtKB ID O95881 UniProtKB Entry Name TXD12_HUMAN GenBank Protein ID 23477616 GenBank Gene ID AF543416 GenAtlas ID TXNDC12 HGNC ID HGNC:24626 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details