GTPase HRas

Details

Name
GTPase HRas
Synonyms
  • c-H-ras
  • H-Ras-1
  • Ha-Ras
  • HRAS1
  • p21ras
  • Transforming protein p21
Gene Name
HRAS
Organism
Humans
Amino acid sequence
>lcl|BSEQ0002141|GTPase HRas
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
Number of residues
189
Molecular Weight
21297.97
Theoretical pI
4.94
GO Classification
Functions
GTP binding / GTPase activity / protein C-terminus binding
Processes
activation of MAPKK activity / axon guidance / blood coagulation / cell cycle arrest / cell proliferation / cell surface receptor signaling pathway / cellular senescence / chemotaxis / endocytosis / ephrin receptor signaling pathway / epidermal growth factor receptor signaling pathway / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / innate immune response / insulin receptor signaling pathway / intrinsic apoptotic signaling pathway / leukocyte migration / MAPK cascade / mitotic cell cycle checkpoint / negative regulation of cell proliferation / negative regulation of gene expression / negative regulation of GTPase activity / negative regulation of neuron apoptotic process / neurotrophin TRK receptor signaling pathway / organ morphogenesis / positive regulation of actin cytoskeleton reorganization / positive regulation of cell migration / positive regulation of cell proliferation / positive regulation of DNA replication / positive regulation of epithelial cell proliferation / positive regulation of ERK1 and ERK2 cascade / positive regulation of GTPase activity / positive regulation of JNK cascade / positive regulation of MAP kinase activity / positive regulation of MAPK cascade / positive regulation of miRNA metabolic process / positive regulation of protein phosphorylation / positive regulation of Ras protein signal transduction / positive regulation of ruffle assembly / positive regulation of transcription from RNA polymerase II promoter / positive regulation of wound healing / protein heterooligomerization / Ras protein signal transduction / regulation of long-term neuronal synaptic plasticity / signal transduction / small GTPase mediated signal transduction / social behavior / stimulatory C-type lectin receptor signaling pathway / synaptic transmission / vascular endothelial growth factor receptor signaling pathway
Components
cytoplasm / cytosol / Golgi apparatus / Golgi membrane / nucleus / perinuclear region of cytoplasm / plasma membrane
General Function
Protein c-terminus binding
Specific Function
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0021284|GTPase HRas (HRAS)
ATGACGGAATATAAGCTGGTGGTGGTGGGCGCCGGCGGTGTGGGCAAGAGTGCGCTGACC
ATCCAGCTGATCCAGAACCATTTTGTGGACGAATACGACCCCACTATAGAGGATTCCTAC
CGGAAGCAGGTGGTCATTGATGGGGAGACGTGCCTGTTGGACATCCTGGATACCGCCGGC
CAGGAGGAGTACAGCGCCATGCGGGACCAGTACATGCGCACCGGGGAGGGCTTCCTGTGT
GTGTTTGCCATCAACAACACCAAGTCTTTTGAGGACATCCACCAGTACAGGGAGCAGATC
AAACGGGTGAAGGACTCGGATGACGTGCCCATGGTGCTGGTGGGGAACAAGTGTGACCTG
GCTGCACGCACTGTGGAATCTCGGCAGGCTCAGGACCTCGCCCGAAGCTACGGCATCCCC
TACATCGAGACCTCGGCCAAGACCCGGCAGGGAGTGGAGGATGCCTTCTACACGTTGGTG
CGTGAGATCCGGCAGCACAAGCTGCGGAAGCTGAACCCTCCTGATGAGAGTGGCCCCGGC
TGCATGAGCTGCAAGTGTGTGCTCTCCTGA
Chromosome Location
11
Locus
11p15.5
External Identifiers
ResourceLink
UniProtKB IDP01112
UniProtKB Entry NameRASH_HUMAN
GenBank Protein ID190891
GenBank Gene IDJ00277
GenAtlas IDHRAS
HGNC IDHGNC:5173
General References
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  12. Hancock JF, Magee AI, Childs JE, Marshall CJ: All ras proteins are polyisoprenylated but only some are palmitoylated. Cell. 1989 Jun 30;57(7):1167-77. [Article]
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  15. Romero F, Martinez-A C, Camonis J, Rebollo A: Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. EMBO J. 1999 Jun 15;18(12):3419-30. [Article]
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  46. Gremer L, De Luca A, Merbitz-Zahradnik T, Dallapiccola B, Morlot S, Tartaglia M, Kutsche K, Ahmadian MR, Rosenberger G: Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation. Hum Mol Genet. 2010 Mar 1;19(5):790-802. doi: 10.1093/hmg/ddp548. Epub 2009 Dec 8. [Article]
  47. Groesser L, Herschberger E, Ruetten A, Ruivenkamp C, Lopriore E, Zutt M, Langmann T, Singer S, Klingseisen L, Schneider-Brachert W, Toll A, Real FX, Landthaler M, Hafner C: Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. Nat Genet. 2012 Jun 10;44(7):783-7. doi: 10.1038/ng.2316. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02210Hexane-1,6-DiolexperimentalunknownDetails
DB03226TrifluoroethanolexperimentalunknownDetails
DB04137Guanosine-5'-TriphosphateexperimentalunknownDetails
DB04315Guanosine-5'-DiphosphateexperimentalunknownDetails
DB08751N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINEexperimentalunknownDetails
DB15588Ursolic acidexperimentalunknownregulatorDetails