DNA nucleotidylexotransferase
Details
- Name
- DNA nucleotidylexotransferase
- Synonyms
- 2.7.7.31
- TDT
- Terminal addition enzyme
- Terminal deoxynucleotidyltransferase
- Terminal transferase
- Gene Name
- DNTT
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009407|DNA nucleotidylexotransferase MDPPRASHLSPRKKRPRQTGALMASSPQDIKFQDLVVFILEKKMGTTRRAFLMELARRKG FRVENELSDSVTHIVAENNSGSDVLEWLQAQKVQVSSQPELLDVSWLIECIRAGKPVEMT GKHQLVVRRDYSDSTNPGPPKTPPIAVQKISQYACQRRTTLNNCNQIFTDAFDILAENCE FRENEDSCVTFMRAASVLKSLPFTIISMKDTEGIPCLGSKVKGIIEEIIEDGESSEVKAV LNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRTLSKVRSDKSLKFTRMQKAGFLYYEDLV SCVTRAEAEAVSVLVKEAVWAFLPDAFVTMTGGFRRGKKMGHDVDFLITSPGSTEDEEQL LQKVMNLWEKKGLLLYYDLVESTFEKLRLPSRKVDALDHFQKCFLIFKLPRQRVDSDQSS WQEGKTWKAIRVDLVLCPYERRAFALLGWTGSRQFERDLRRYATHERKMILDNHALYDKT KRIFLKAESEEEIFAHLGLDYIEPWERNA
- Number of residues
- 509
- Molecular Weight
- 58535.73
- Theoretical pI
- Not Available
- GO Classification
- FunctionsDNA binding / DNA nucleotidylexotransferase activity / DNA-directed DNA polymerase activity / metal ion bindingProcessesDNA metabolic process / DNA modificationComponentscytoplasm / nucleoplasm / nucleus
- General Function
- Metal ion binding
- Specific Function
- Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0013140|DNA nucleotidylexotransferase (DNTT) ATGGATCCACCACGAGCGTCCCACTTGAGCCCTCGGAAGAAGAGACCCCGGCAGACGGGT GCCTTGATGGCCTCCTCTCCTCAAGACATCAAATTTCAAGATTTGGTCGTCTTCATTTTG GAGAAGAAAATGGGAACCACCCGCAGAGCGTTCCTCATGGAGCTGGCCCGCAGGAAAGGG TTCAGGGTTGAAAATGAGCTCAGTGATTCTGTCACCCACATCGTAGCAGAGAACAACTCG GGTTCGGATGTTCTGGAGTGGCTTCAAGCACAGAAAGTACAAGTCAGCTCACAACCAGAG CTCCTCGATGTCTCCTGGCTGATCGAATGCATAAGAGCAGGGAAACCGGTGGAAATGACA GGAAAACACCAGCTTGTTGTGAGAAGAGACTATTCAGATAGCACCAACCCAGGCCCCCCG AAGACTCCACCAATTGCTGTACAAAAGATCTCCCAGTATGCGTGTCAGAGAAGAACCACT TTAAACAACTGTAACCAGATATTCACGGATGCCTTTGATATACTGGCTGAAAACTGTGAG TTTAGAGAAAATGAAGACTCCTGTGTGACATTTATGAGAGCAGCTTCTGTATTGAAATCT CTGCCATTCACAATCATCAGTATGAAGGACACAGAAGGAATTCCCTGCCTGGGGTCCAAG GTGAAGGGTATCATAGAGGAGATTATTGAAGATGGAGAAAGTTCTGAAGTTAAAGCTGTG TTAAATGATGAACGATATCAATCCTTCAAACTCTTTACTTCTGTATTTGGAGTGGGGCTG AAGACTTCTGAGAAGTGGTTCAGGATGGGTTTCAGAACTCTGAGTAAAGTAAGGTCGGAC AAAAGCCTGAAATTTACACGAATGCAGAAAGCAGGATTTCTGTATTATGAAGACCTTGTC AGCTGTGTGACCAGGGCAGAAGCAGAGGCCGTCAGTGTGCTGGTTAAAGAGGCTGTCTGG GCATTTCTTCCGGATGCTTTCGTCACCATGACAGGAGGGTTCCGGAGGGGTAAGAAGATG GGGCATGATGTAGATTTTTTAATTACCAGCCCAGGATCAACAGAGGATGAAGAGCAACTT TTACAGAAAGTGATGAACTTATGGGAAAAGAAGGGATTACTTTTATATTATGACCTTGTG GAGTCAACATTTGAAAAGCTCAGGTTGCCTAGCAGGAAGGTTGATGCTTTGGATCATTTT CAAAAGTGCTTTCTGATTTTCAAATTGCCTCGTCAAAGAGTGGACAGTGACCAGTCCAGC TGGCAGGAAGGAAAGACCTGGAAGGCCATCCGTGTGGATTTAGTTCTGTGCCCCTACGAG CGTCGTGCCTTTGCCCTGTTGGGATGGACTGGCTCCCGGTTTGAGAGAGACCTCCGGCGC TATGCCACACATGAGCGGAAGATGATTCTGGATAACCATGCTTTATATGACAAGACCAAG AGGATATTCCTCAAAGCAGAAAGTGAAGAAGAAATTTTTGCGCATCTGGGATTGGATTAT ATTGAACCGTGGGAAAGAAATGCCTAG
- Chromosome Location
- 10
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P04053 UniProtKB Entry Name TDT_HUMAN HGNC ID HGNC:2983 - General References
- Peterson RC, Cheung LC, Mattaliano RJ, White ST, Chang LM, Bollum FJ: Expression of human terminal deoxynucleotidyl transferase in Escherichia coli. J Biol Chem. 1985 Sep 5;260(19):10495-502. [Article]
- Riley LK, Morrow JK, Danton MJ, Coleman MS: Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5' flanking region. Proc Natl Acad Sci U S A. 1988 Apr;85(8):2489-93. [Article]
- Ibe S, Fujita K, Toyomoto T, Shimazaki N, Kaneko R, Tanabe A, Takebe I, Kuroda S, Kobayashi T, Toji S, Tamai K, Yamamoto H, Koiwai O: Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen. Genes Cells. 2001 Sep;6(9):815-24. [Article]
- Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Koiwai O, Morita A: Isolation of putative promoter region for human terminal deoxynucleotidyltransferase gene. Biochem Biophys Res Commun. 1988 Jul 15;154(1):91-100. [Article]
- Peterson RC, Cheung LC, Mattaliano RJ, Chang LM, Bollum FJ: Molecular cloning of human terminal deoxynucleotidyltransferase. Proc Natl Acad Sci U S A. 1984 Jul;81(14):4363-7. [Article]
- Yang B, Gathy KN, Coleman MS: Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase. J Biol Chem. 1994 Apr 22;269(16):11859-68. [Article]
- Yamashita N, Shimazaki N, Ibe S, Kaneko R, Tanabe A, Toyomoto T, Fujita K, Hasegawa T, Toji S, Tamai K, Yamamoto H, Koiwai O: Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65. Genes Cells. 2001 Jul;6(7):641-52. [Article]
- Fujita K, Shimazaki N, Ohta Y, Kubota T, Ibe S, Toji S, Tamai K, Fujisaki S, Hayano T, Koiwai O: Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. Genes Cells. 2003 Jun;8(6):559-71. [Article]
- Mahajan KN, Mitchell BS: Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10746-51. Epub 2003 Sep 5. [Article]
- Fujisaki S, Sato A, Toyomoto T, Hayano T, Sugai M, Kubota T, Koiwai O: Direct binding of TReP-132 with TdT results in reduction of TdT activity. Genes Cells. 2006 Jan;11(1):47-57. [Article]