Carboxypeptidase G2

Details

Name
Carboxypeptidase G2
Synonyms
  • 3.4.17.11
  • CPDG2
  • Folate hydrolase G2
  • Glutamate carboxypeptidase
  • Pteroylmonoglutamic acid hydrolase G2
Gene Name
cpg2
Organism
Pseudomonas sp. (strain RS-16)
Amino acid sequence
>lcl|BSEQ0052772|Carboxypeptidase G2
MRPSIHRTAIAAVLATAFVAGTALAQKRDNVLFQAATDEQPAVIKTLEKLVNIETGTGDA
EGIAAAGNFLEAELKNLGFTVTRSKSAGLVVGDNIVGKIKGRGGKNLLLMSHMDTVYLKG
ILAKAPFRVEGDKAYGPGIADDKGGNAVILHTLKLLKEYGVRDYGTITVLFNTDEEKGSF
GSRDLIQEEAKLADYVLSFEPTSAGDEKLSLGTSGIAYVQVNITGKASHAGAAPELGVNA
LVEASDLVLRTMNIDDKAKNLRFNWTIAKAGNVSNIIPASATLNADVRYARNEDFDAAMK
TLEERAQQKKLPEADVKVIVTRGRPAFNAGEGGKKLVDKAVAYYKEAGGTLGVEERTGGG
TDAAYAALSGKPVIESLGLPGFGYHSDKAEYVDISAIPRRLYMAARLIMDLGAGK
Number of residues
415
Molecular Weight
43931.68
Theoretical pI
Not Available
GO Classification
Functions
carboxypeptidase activity / metal ion binding / metallopeptidase activity
General Function
Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity.
Specific Function
Carboxypeptidase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP06621
UniProtKB Entry NameCBPG_PSES6
General References
  1. Minton NP, Atkinson T, Bruton CJ, Sherwood RF: The complete nucleotide sequence of the Pseudomonas gene coding for carboxypeptidase G2. Gene. 1984 Nov;31(1-3):31-8. doi: 10.1016/0378-1119(84)90192-6. [Article]
  2. Sherwood RF, Melton RG, Alwan SM, Hughes P: Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16. Use of a novel triazine dye affinity method. Eur J Biochem. 1985 May 2;148(3):447-53. doi: 10.1111/j.1432-1033.1985.tb08860.x. [Article]
  3. Rowsell S, Pauptit RA, Tucker AD, Melton RG, Blow DM, Brick P: Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy. Structure. 1997 Mar 15;5(3):337-47. doi: 10.1016/s0969-2126(97)00191-3. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00563MethotrexateapprovedunknownsubstrateDetails