Nucleoside-specific channel-forming protein tsx

Details

Name

Nucleoside-specific channel-forming protein tsx

Synonyms

• nupA

Gene Name

tsx

Organism

Escherichia coli (strain K12)

Amino acid sequence

>lcl|BSEQ0016662|Nucleoside-specific channel-forming protein tsx
MKKTLLAAGAVLALSSSFTVNAAENDKPQYLSDWWHQSVNVVGSYHTRFGPQIRNDTYLE
YEAFAKKDWFDFYGYADAPVFFGGNSDAKGIWNHGSPLFMEIEPRFSIDKLTNTDLSFGP
FKEWYFANNYIYDMGRNKDGRQSTWYMGLGTDIDTGLPMSLSMNVYAKYQWQNYGAANEN
EWDGYRFKIKYFVPITDLWGGQLSYIGFTNFDWGSDLGDDSGNAINGIKTRTNNSIASSH
ILALNYDHWHYSVVARYWHDGGQWNDDAELNFGNGNFNVRSTGWGGYLVVGYNF

Number of residues

294

Molecular Weight

33588.835

Theoretical pI

4.93

GO Classification

Functions

nucleoside-specific channel forming porin activity

Processes

ion transport / nucleoside transmembrane transport / nucleoside transport / viral entry into host cell

Components

cell outer membrane / pore complex

General Function

Nucleoside-specific channel forming porin activity

Specific Function

Constitutes the receptor for colicin K and phage T6, and functions as substrate-specific channel for nucleosides and deoxynucleosides.

Pfam Domain Function

• Channel_Tsx (PF03502)

Transmembrane Regions

Not Available

Cellular Location

Cell outer membrane

Gene sequence

>lcl|BSEQ0016663|Nucleoside-specific channel-forming protein tsx (tsx)
ATGAAAAAAACATTACTGGCAGCCGGTGCGGTACTGGCGCTCTCTTCGTCTTTTACTGTC
AACGCAGCTGAAAACGACAAACCGCAGTATCTTTCCGACTGGTGGCACCAGAGCGTTAAC
GTTGTCGGAAGCTATCACACCCGTTTCGGACCGCAGATCCGCAACGATACCTACCTTGAG
TACGAAGCATTCGCTAAAAAAGACTGGTTCGACTTCTATGGTTATGCGGATGCGCCGGTA
TTCTTCGGCGGTAACTCCGATGCTAAAGGTATCTGGAACCACGGTTCTCCGCTGTTTATG
GAAATCGAACCACGTTTCTCCATCGACAAGCTGACCAATACTGACCTTAGCTTCGGTCCG
TTCAAAGAGTGGTACTTCGCGAACAACTACATTTACGACATGGGTCGTAATAAAGATGGT
CGCCAGAGCACCTGGTACATGGGTCTGGGTACCGATATCGACACTGGCCTGCCGATGAGC
CTGTCCATGAACGTCTATGCGAAATACCAGTGGCAGAACTATGGCGCAGCGAACGAAAAC
GAGTGGGACGGTTACCGTTTCAAAATTAAATACTTTGTGCCGATTACCGATCTGTGGGGC
GGTCAGCTGAGCTACATCGGCTTCACCAACTTCGACTGGGGTTCCGATTTAGGGGATGAC
AGCGGTAACGCAATCAACGGTATTAAGACCCGTACTAATAACTCTATCGCTTCCAGCCAT
ATTCTGGCTCTGAACTACGATCACTGGCACTACTCTGTCGTAGCTCGTTACTGGCACGAC
GGTGGTCAGTGGAACGACGATGCAGAACTGAACTTCGGCAACGGCAACTTCAACGTTCGC
TCTACCGGCTGGGGTGGTTACCTGGTAGTAGGTTACAACTTCTGA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P0A927
UniProtKB Entry Name	TSX_ECOLI
GenBank Gene ID	M57685

General References

1. Bremer E, Middendorf A, Martinussen J, Valentin-Hansen P: Analysis of the tsx gene, which encodes a nucleoside-specific channel-forming protein (Tsx) in the outer membrane of Escherichia coli. Gene. 1990 Nov 30;96(1):59-65. [Article]
2. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
3. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
4. Maier C, Middendorf A, Bremer E: Analysis of a mutated phage T6 receptor protein of Escherichia coli K 12. Mol Gen Genet. 1990 May;221(3):491-4. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB02745	Uridine	experimental, investigational	unknown		Details
DB04485	Thymidine	experimental, investigational	unknown		Details