Precorrin-8X methylmutase
Details
- Name
- Precorrin-8X methylmutase
- Synonyms
- 5.4.99.61
- HBA synthase
- Precorrin isomerase
- Gene Name
- cobH
- Organism
- Pseudomonas denitrificans
- Amino acid sequence
>lcl|BSEQ0021980|Precorrin-8X methylmutase MPEYDYIRDGNAIYERSFAIIRAEADLSRFSEEEADLAVRMVHACGSVEATRQFVFSPDF VSSARAALKAGAPILCDAEMVAHGVTRARLPAGNEVICTLRDPRTPALAAEIGNTRSAAA LKLWSERLAGSVVAIGNAPTALFFLLEMLRDGAPKPAAILGMPVGFVGAAESKDALAENS YGVPFAIVRGRLGGSAMTAAALNSLARPGL
- Number of residues
- 210
- Molecular Weight
- 22063.995
- Theoretical pI
- 5.83
- GO Classification
- Functionsprecorrin-8X methylmutase activityProcessescobalamin biosynthetic process
- General Function
- Precorrin-8x methylmutase activity
- Specific Function
- Catalyzes the conversion of precorrin-8X to hydrogenobyrinate.
- Pfam Domain Function
- CbiC (PF02570)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0003597|633 bp ATGCCTGAGTATGATTACATTCGCGATGGCAACGCCATCTACGAGCGTTCCTTCGCCATC ATCCGCGCCGAGGCCGATCTGTCGCGCTTCTCCGAAGAGGAAGCGGATCTGGCTGTGCGC ATGGTGCACGCCTGCGGTTCCGTCGAGGCGACCAGGCAGTTCGTGTTTTCTCCCGATTTC GTAAGCTCGGCCCGTGCGGCGCTGAAAGCCGGTGCGCCGATCCTCTGCGATGCCGAGATG GTTGCGCACGGTGTCACCCGCGCCCGTCTGCCGGCCGGCAACGAGGTGATCTGCACGCTG CGCGATCCTCGCACGCCCGCACTTGCGGCCGAGATCGGCAACACCCGCTCCGCCGCAGCC CTGAAGCTCTGGAGCGAGCGGCTGGCCGGTTCGGTGGTCGCGATCGGCAACGCGCCGACG GCGTTGTTCTTCCTCTTGGAAATGCTGCGCGACGGCGCGCCGAAGCCGGCGGCAATCCTC GGCATGCCCGTCGGTTTCGTCGGTGCGGCGGAATCGAAGGATGCGCTGGCCGAGAACTCC TATGGCGTTCCCTTCGCCATCGTGCGCGGCCGCCTCGGCGGGAGTGCCATGACGGCGGCA GCGCTTAACTCGCTCGCGAGGCCGGGCCTGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P21638 UniProtKB Entry Name COBH_PSEDE GenBank Protein ID 151173 GenBank Gene ID M59301 - General References
- Crouzet J, Cameron B, Cauchois L, Rigault S, Rouyez MC, Blanche F, Thibaut D, Debussche L: Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid. J Bacteriol. 1990 Oct;172(10):5980-90. [Article]
- Thibaut D, Couder M, Famechon A, Debussche L, Cameron B, Crouzet J, Blanche F: The final step in the biosynthesis of hydrogenobyrinic acid is catalyzed by the cobH gene product with precorrin-8x as the substrate. J Bacteriol. 1992 Feb;174(3):1043-9. [Article]
- Shipman LW, Li D, Roessner CA, Scott AI, Sacchettini JC: Crystal structure of precorrin-8x methyl mutase. Structure. 2001 Jul 3;9(7):587-96. [Article]